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“He (Joe Strummer) was one of the great English rock stars, bold and influential beyond reckoning. We could do with another one like him, right now.”
David Sinclair
“Broken DNA causes genome instability, I wrote, which distracts the Sir2 protein, which changes the epigenome, causing the cells to lose their identity and become sterile while they fixed the damage. Those were the analog scratches on the digital DVDs. Epigenetic changes cause aging.”
David Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Sirtuins instruct the histone spooling proteins to bind up DNA tightly, while they leave other regions to flail around. In this way, some genes stay silent, while others can be accessed by DNA-binding transcription factors that turn genes on.12 Accessible genes are said to be in “euchromatin,” while silent genes are in “heterochromatin.” By removing chemical tags on histones, sirtuins help prevent transcription factors from binding to genes, converting euchromatin into heterochromatin.”
David Sinclair, Lifespan: Why We Age—and Why We Don't Have To

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