1
Afterland

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3.25 avg rating — 5,319 ratings
""It takes place during "Manfall", a 2020 pandemic which has killed off almost all the world's men. Three years later In the United States, Cole and her twelve-year-old son, Miles are trying to flee to their home in South Africa.""
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2
Earth Abides

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3.94 avg rating — 34,847 ratings
""A disease of unparalleled destructive force has sprung up almost simultaneously in every corner of the globe, all but destroying the human race. One survivor, strangely immune to the effects of the epidemic, ventures forward to experience a world without man.""
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3
The Book of M

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3.69 avg rating — 22,125 ratings
""a mysterious plague where people lose their shadows and, with them, their memories, forcing loved ones to risk everything to find them.""
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4
The Andromeda Strain (Andro...

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3.91 avg rating — 274,328 ratings
""When an unmanned satellite returns to earth lethally contaminated, four American scientists are ordered to a secret lab to work against the threat of a worldwide epidemic.""
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5
Station Eleven

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4.07 avg rating — 631,821 ratings
""...follows a traveling troupe of actors and musicians, the Traveling Symphony, performing Shakespeare in the scattered settlements of a world devastated by a flu pandemic.""
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6
Severance

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3.88 avg rating — 136,023 ratings
""...she navigates a global pandemic that turns victims into mindless, routine-driven zombies. The story contrasts her monotonous pre-plague life with the "after," where she joins a group of survivors...""
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7
Contagion (Contagion, #1)

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3.87 avg rating — 7,679 ratings
""After receiving an urgent SOS from a work detail on a distant planet, a skeleton crew is dispatched to perform a standard search-and-rescue mission. But when the crew arrives, they find an abandoned site, littered with rotten food, discarded weapons...and dead bodies.""
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8
Speaker for the Dead (Ender...

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4.11 avg rating — 275,185 ratings
""The [Descolada] virus actively unglues and scrambles the DNA of living cells. It causes rapid tissue decay, cancerous growths, causes extra limbs to sprout, and results in agonizing death.""
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9
Leviathan Wakes (The Expans...

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4.31 avg rating — 329,326 ratings
""The protomolecule is an infectious agent of extraterrestrial origin that is described as “a set of free-floating instructions designed to adapt to and guide other replicating systems.” It melds with the body, feeding on biomass...""
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10
Rise of the Planet of the A...

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3.35 avg rating — 20 ratings
""Originally a retrovirus tested on apes in hopes of curing Alzheimer's disease, the Simian Flu proved lethal to humans but imbued apes with incredible power.""
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11
A Game of Thrones (A Song o...

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4.45 avg rating — 2,775,686 ratings
""Grayscale is a dreaded, highly infectious disease that renders the flesh cracked, flaking, and stone-like. Victims slowly die over the course of years, with more suffering as it progresses.""
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12
Dead Until Dark (Sookie Sta...

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3.97 avg rating — 563,472 ratings
""Hepatitis D... a non-fatal virus that is harmless to humans but weakens vampires, making them easy to stake.""
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13
Outbreak (Dr. Marissa Blume...

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3.98 avg rating — 57,773 ratings
""...follows Dr. Marissa Blumenthal, a CDC virologist, as she investigates a string of deadly, geographically unrelated virus outbreaks.""
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14
Virus: The Day of Resurrection

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3.70 avg rating — 261 ratings
""Two microbes are found to be coccus-shaped supergerms capable of surviving in absolute zero and have the potential to grow exponentially in terrestrial conditions.""
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15
The Maze Runner (The Maze R...

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4.06 avg rating — 1,717,418 ratings
""The Flare, medical name Virus VC321xb47 was a man-made disease created by the Post-Flares Coalition after the Sun Flares. The Flare was created to decrease the population to a point where the remaining food supplies would be steady.""
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16
Harry Potter and the Order ...

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4.50 avg rating — 3,862,926 ratings
""Spattergroit is a highly contagious, revolting magical skin disease in the Harry Potter universe, caused by a fungus that creates purple pustules and can leave permanent scars, sometimes rendering victims unable to speak. It is famously used by the Weasley family to disguise their family ghoul...""
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17
The Stand

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4.35 avg rating — 849,491 ratings
""Captain Trips was developed as a biological weapon. It begins with symptoms similar to a common cold before developing into unbearable pain, swelling, and delirium. Its fast-evolving nature makes curing it impossible.""
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18
Godblight (Dark Imperium #3)

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4.25 avg rating — 2,217 ratings
""...supernatural plague engineered by the Plague God Nurgle to destroy immortal demigods. It is so potent that it can erase a victim's soul and was terrifying enough to frighten even its demonic creators.""
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19
The Last of Us: American Dr...

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3.82 avg rating — 4,750 ratings
""The Cordyceps Brain Infection: A mutated fungus-virus that completely hijacks the host's nervous system, turning humans into aggressive predators in varying stages of terrifying fungal mutation...""
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20
The Umbrella Conspiracy (Re...

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3.93 avg rating — 9,079 ratings
""T virus mutates cellular structure, killing higher brain function and transforming the infected into voracious, mutating zombies.""
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21
X-Force (1991-2002) #18

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4.13 avg rating — 45 ratings
""...Gordon Lefferts, a scientist working for Sinister, opens the canister after Stryfe is apparently killed by Cable, releasing the [Legacy] virus... The virus kills various mutants, including Magik, Mastermind, and Pyro...""
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22
The Masque of the Red Death

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4.05 avg rating — 48,483 ratings
""A disease resembling an epidemic plague. Represents death's inevitability, even to the rich who try to avoid it.""
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23
Crossed + One Hundred, Volu...

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3.71 avg rating — 667 ratings
""...a global pandemic that turns people into violent, depraved maniacs with a cross-shaped rash on their faces, known as "the Crossed".""
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24
Blindness

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4.18 avg rating — 348,509 ratings
""A city is hit by an epidemic of "white blindness" that spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations, and assaulting women.""
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25
The Last Man

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3.38 avg rating — 7,157 ratings
""...the ending portrays humanity's total eradication by a global plague. The protagonist, Lionel Verney, is the sole survivor, left completely alone to wander the ruins of Rome and set sail across the Mediterranean Sea as a solitary witness...""
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26
The Country of Ice Cream Star

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3.60 avg rating — 2,869 ratings
""In post-pandemic Massachusetts, cabals of children run wild—children being the only humans left, as everyone now dies from a disease called “posies” by the age of 20.""
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27
The Dog Stars

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3.95 avg rating — 76,305 ratings
""...Hig, who survived a devastating flu pandemic. Living on an abandoned Colorado airfield, he takes to the skies in his 1956 Cessna. When a mysterious radio transmission offers a glimmer of hope, he risks everything to fly into the unknown.""
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28
A Boy and His Dog at the En...

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4.15 avg rating — 21,841 ratings
""...a boy named Griz who lives in a world where a fertility crisis has decimated the population, and he must journey across a changed landscape to rescue his stolen dog, Jess...""
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29
13 Days to Die

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3.88 avg rating — 338 ratings
""An American intelligence officer and a headstrong female virus hunter team up to investigate a mysterious epidemic in a remote Tibetan village...""
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30
Oryx and Crake (MaddAddam, #1)

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really liked it 4.00 avg rating — 291,617 ratings
""...Snowman, known as Jimmy before mankind was overwhelmed by a plague, is struggling to survive in a world where he may be the last human, and mourning the loss of his best friend, Crake, and the beautiful and elusive Oryx whom they both loved.""
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31
The Children of Men

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3.67 avg rating — 53,248 ratings
""...in a future England (2021) where humanity faces extinction due to universal male sterility, with the last generation of children now adults.""
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32
The Death of Grass

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3.89 avg rating — 11,399 ratings
""...a virus that wipes out all grasses, leading to global famine and societal collapse. The story follows the Custance family as they flee London for a remote farm, witnessing the rapid descent into barbarism as civilization breaks down... ""
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