Amit Ray's Blog, page 7

Fasting and Diet Planning for Cancer Prevention: A Mathematical Model

Fasting and diet play a powerful role in reducing inflammation by modulating pro-inflammatory cytokines. Explore the science behind how these practices can help prevent cancer. Cancer remains one of the leading causes of mortality worldwide.  Biological mechanisms such as DNA repair, apoptosis (programmed cell death), and immune surveillance play crucial roles in preventing cancer. Diet and metabolic factors are also crucial in cancer prevention. Recent research has highlighted fasting and… Read More »Fasting and Diet Planning for Cancer Prevention: A Mathematical Model

Purusha Suktam Benefits, Meaning, Science and Lyrics

Benefits | Meaning |  Science  | Lyrics  Purusha Suktam is an ancient hymn from the RigVeda dedicated to cosmic being, the deity of cosmic protection, nourishments, wealth, prosperity. The hymn remains a timeless expression of the Vedic worldview, blending cosmology, spirituality, and philosophy into a unified vision of existence. Its enduring relevance underscores its profound impact on Indian culture and philosophy. “Purusha Suktam meditation reveals the eternal cosmic Self. The… Read More »Purusha Suktam Benefits, Meaning, Science and Lyrics

Purusha Suktam Science Significance and Meanings

The Purusha Suktam, found in the Rigveda, is a profound hymn that glorifies the cosmic being, Purusha, whose transcendence and immanence create and sustain the universe. This hymn is an essential part of Vedic literature, blending cosmology, spirituality, and metaphysics into a coherent narrative. It is often recited in various rituals to invoke the universal energy and to understand the interconnectedness of existence. The hymn remains a timeless expression of… Read More »Purusha Suktam Science Significance and Meanings

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Brain Fluid Dynamics of CSF, ISF, and CBF: A Computational Model

The human brain is a highly complex organ where various fluids play essential roles in maintaining its functions, from nutrient delivery to waste clearance. Among these, Cerebrospinal Fluid (CSF), Interstitial Fluid (ISF), and Cerebral Blood Flow (CBF) are critical components that directly impact brain health and cognitive performance. These fluids interact dynamically, influencing each other’s behavior in ways that are crucial for brain function, especially in terms of metabolic activity,… Read More »Brain Fluid Dynamics of CSF, ISF, and CBF: A Computational Model

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What is the Root Chakra? Meaning, Location, Side Effects, and How to Unblock It

Do you know that the Root Chakra can increase your stability, energy, and survival instincts? The Root Chakra, also known as Muladhara in Sanskrit, is one of the seven energy centers or chakras in the body. Located at the base of the spine, near the perineum. It is positioned between the coccyx (tailbone) and the pelvic floor. This chakra is associated with grounding, stability, and survival instincts. It represents your… Read More »What is the Root Chakra? Meaning, Location, Side Effects, and How to Unblock It

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Five Steps to Building AI Agents with Higher Vision and Values

Building reliable AI agents with higher values and safety is a challenge. It requires balancing advanced technological innovation with rigorous testing, transparency, and accountability. This article explores five key steps and the top ten ethical principles for developing reliable AI agents with higher values. Developing AI agents is not merely a technological endeavor; it is an artistic process of harmonizing purpose, integrating human values, intelligence, and adaptability. At our Compassionate… Read More »Five Steps to Building AI Agents with Higher Vision and Values

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The Path of Stilling the Mind: Nirodha Samapatti

Nirodha Samāpatti is an advanced meditative state in Buddhist practice where all mental activities, sensations, and awareness temporarily stop. It’s a state of deep stillness, achieved through intense focus and training, that allows the mind and body to rest completely. Practitioners experience this as a way to touch ultimate peace and gain insight into reality beyond ordinary thoughts and feelings. Through the cessation of perception, feeling, and consciousness, practitioners touch… Read More »The Path of Stilling the Mind: Nirodha Samapatti

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Srotas: The 16 Flow Channels of Life Force in Ayurveda

In Ayurveda, the term Srotas (स्रोतस्) refers to the flow channels or pathways of life force in the body that are responsible for the transportation of substances such as nutrients, fluids, waste products, and energy. Derived from the root “sru” (स्रु), which means “to flow,” srotas are considered essential for maintaining the balance and functioning of the body. Here we focused on the central role of srotas in the flow… Read More »Srotas: The 16 Flow Channels of Life Force in Ayurveda

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Ayurveda Prakriti and Vikriti: Genotype and Phenotype

In Ayurveda, two key concepts—Prakriti (innate constitution) and Vikriti (current state of imbalance)—parallel the scientific notions of genotype and phenotype. This article explores how these frameworks intersect, presenting a novel, integrative approach to understanding health and developing personalized healthcare strategies. In Ayurveda, Prakriti and Vikriti form the foundation for understanding an individual’s health and well-being. These two concepts offer insights into both the natural constitution of a person and any… Read More »Ayurveda Prakriti and Vikriti: Genotype and Phenotype

PK/PD Modeling of Ashwagandha and Giloy: Ayurvedic Herbs

Here, we discuss the pharmacokinetics (PK) and pharmacodynamics (PD) models of Ashwagandha and Giloy, two prominent herbs in Ayurvedic medicine. The PK model focuses on how these herbs move through the body, while the PD model examines their effects and interactions within the body.

Ashwagandha and Giloy are widely recognized for their adaptogenic, immune-boosting, anti-inflammatory, and stress-relieving properties. Although the benefits of these herbs are time-tested, significant gaps remain in the scientific framework needed to fully explore their potential in addressing complex health issues.

This article explores the exciting potential of pharmacokinetic (PK) and pharmacodynamic (PD) modeling to bridge these gaps, offering new insights into how Ashwagandha and Giloy can be utilized to tackle a range of health challenges.

Introduction

Ayurveda, one of the oldest systems of medicine, uses natural herbs to promote health, treat diseases, and maintain overall well-being. Among the myriad of herbs used in Ayurvedic practice, Ashwagandha (Withania somnifera) and Giloy (Tinospora cordifolia) have gained significant attention for their medicinal properties. With the advent of modern pharmacological sciences, especially pharmacokinetics (PK) and pharmacodynamics (PD), there is growing interest in understanding the mechanisms through which these herbs exert their therapeutic effects. PK/PD modeling allows us to quantitatively analyze the interactions between the active compounds in these herbs and the body, leading to better optimization of their therapeutic potential.… Read more..

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