David Perlmutter > Quotes

“brain-derived neurotrophic factor,” or BDNF. BDNF plays a key role in creating new neurons. But beyond its role in neurogenesis, BDNF protects existing neurons, ensuring their survivability”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“It’s now generally accepted that Mesmer was actually treating psychosomatic illness, and he profited mightily from people’s gullibility. In retrospect, his theories and practices sound ridiculous, but in truth, the story of Mesmer parallels many stories of today. It’s not so ridiculous to imagine people falling prey to products, procedures, and health claims that are brilliantly marketed. Every day we hear of some news item related to health. We are bombarded by messages about our health — good, bad, and confusingly contradictory. And we are literally mesmerized by these messages. Even the smart, educated, cautious, and skeptical consumer is mesmerized. It’s hard to separate truth from fiction, and to know the difference between what’s healthful and harmful when the information and endorsements come from “experts.”
― David Perlmutter

“ApoE ε2 is relatively rare, but if you inherit this allele, you’re more likely to develop Alzheimer’s disease later in life. ApoE ε3 is the most common allele, but it’s believed to neither increase nor decrease your risk. ApoE ε4, however, is the one typically mentioned in the media and feared the most. In”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“people who start taking cholesterol-lowering medication (i.e., statins) can become much more depressed.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Professor of Biophysics at Iowa State University Dr. Yeon-Kyun Shin is a noted authority on how cholesterol functions within neural networks to transmit messages. He put it bluntly in an interview for a ScienceDaily reporter:28 If you deprive cholesterol from the brain, then you directly affect the machinery that triggers the release of neurotransmitters. Neurotransmitters affect the data-processing and memory functions. In other words—how smart you are and how well you remember things. If you try to lower the cholesterol by taking medication that is attacking the machinery of cholesterol synthesis in the liver, that medicine goes to the brain too. And then it reduces the synthesis of cholesterol, which is necessary in the brain. Our study shows there is a direct link between cholesterol and the neurotransmitter release, and we know exactly the molecular mechanics of what happens in the cells. Cholesterol changes the shape of the proteins to stimulate thinking and memory.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“The one variable that clearly stood out above all others was whether or not the mice had a running wheel. It didn’t matter if they had things to play with in their cages. The animals that exercised were the ones who had healthier brains and outperformed on the cognitive tests.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“At the root of the problem? That sticky wheat protein, gluten. Although the jury is still out on the connections between gluten sensitivity and behavioral or psychological issues, we do know a few facts: People with celiac disease may be at increased risk for developmental delay, learning difficulties, tic disorders, and ADHD.6 Depression and anxiety are often severe in patients with gluten sensitivity.7, 8 This is primarily due to the cytokines that block production of critical brain neurotransmitters like serotonin, which is essential in regulating mood. With the elimination of gluten and often dairy, many patients have been freed from not just their mood disorders but other conditions caused by an overactive immune system, like allergies and arthritis. As many as 45 percent of people with autism spectrum disorders (ASD) have gastrointestinal problems.9 Although not all gastrointestinal symptoms in ASD result from celiac disease, data shows an increased prevalence of celiac in pediatric cases of autism, compared to the general pediatric population. The good news is that we can reverse many of the symptoms of neurological, psychological, and behavioral disorders just by going gluten-free and adding supplements like DHA and probiotics to our diet.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Brain dysfunction starts in your daily bread, and I’m going to prove it. I’ll state it again because I realize it sounds absurd: Modern grains are silently destroying your brain.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“The results of the study revealed that those individuals in the lowest 10 percent of daily physical activity had a 230 percent increased risk of developing Alzheimer’s disease compared to those in the highest 10 percent of physical activity. When”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“reduce the risk of LDL oxidation—not necessarily levels of LDL itself. A principal player in that risk of oxidation is higher levels of glucose; LDL is far more likely to become oxidized in the presence of sugar molecules that will bind to it and change its shape. Glycosylated”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Surge una pregunta lógica: ¿cómo se relaciona la depresión con el daño intestinal? Una vez que el recubrimiento del intestino ha sido dañado por la enfermedad celiaca pierde su efectividad para absorber nutrientes esenciales, muchos de los cuales mantienen la salud del cerebro, como el zinc, el triptófano y el complejo B. Además, estos nutrientes son necesarios para la producción de sustancias neurológicas como la serotonina. Asimismo, la mayoría de las hormonas y las “sustancias de la felicidad” se producen en torno a los intestinos en lo que los científicos ahora denominan el “segundo cerebro”.39 Las células nerviosas presentes en el intestino no sólo regulan los músculos, las células inmunológicas y las hormonas, sino que también producen de 80 a 90% de la serotonina del cuerpo. De hecho, el cerebro del intestino genera más serotonina que el cerebro que tienes dentro del cráneo.”
― David Perlmutter, Cerebro de pan (Colección Vital): La devastadora verdad sobre los efectos del trigo, el azúcar y los carbohidratos

“often a fully preventable problem. If you’re a chronic headache sufferer, why not try a gluten-free diet? What have you got to lose?”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“The more we moved, the fitter our brain became. And even today our brain’s healthy functioning requires regular physical activity despite the passage of time and ills of the aging process.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Coconut oil, from which we derive MCTs, is a rich source of an important precursor molecule for beta-hydroxybutyrate and is a helpful approach to treating Alzheimer’s disease.24”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“A purely ketogenic diet is one that derives 80 to 90 percent of calories from fat, and the rest from carbohydrate and protein.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“THE GLUTEN POLICE The following grains and starches contain gluten: barley bulgur couscous farina graham flour kamut matzo rye semolina spelt triticale wheat wheat germ”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Fortalecer el revestimiento intestinal y disminuir la permeabilidad intestinal. Disminuir los niveles de LPS, la molécula inflamatoria que puede ser peligrosa si llega al torrente sanguíneo. Aumentar el FNDC, la hormona de crecimiento cerebral. Mantener un equilibrio general para controlar cualquier posible colonia bacteriana rebelde.”
― David Perlmutter, Alimenta tu cerebro: El sorprendente poder de la flora intestinal para sanar y proteger tu cerebro...

“According to the latest research, we owe our tremendous brains to the need to think… and the need to run.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Modern grains are silently destroying your brain.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“What’s more, as we consume carbohydrates we stimulate an enzyme called lipoprotein lipase that tends to drive fat into the cell; the insulin secreted when we consume carbohydrates makes matters worse by triggering enzymes that lock fat tightly into our fat cells.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“The bottom line is that if you want to reduce oxidative stress and the action of free radicals harming your brain, you have to reduce the glycation of proteins. Which is to say, you have to diminish the availability of sugar. Pure and simple.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“For people who never consumed fish, the risk of dementia and Alzheimer’s disease during the four-year follow-up period was increased by 37 percent. In those individuals who consumed fish on a daily basis, risk for these diseases was reduced by 44 percent. Regular”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“gluten breaks down in the stomach to become a mix of polypeptides that can cross the blood-brain barrier. Once they gain entry, they can then bind to the brain’s morphine receptor to produce a sensorial high. This”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“As we’ve seen, science is only recently discovering that both fat and cholesterol are severely deficient in diseased brains and that high total cholesterol levels in late life are associated with increased longevity.24”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“one molecule of vitamin C is oxidized by one free radical. (This one-to-one chemistry is called a stoichiometric reaction by chemists.) Can you imagine how much vitamin C or other oral antioxidant it would take to neutralize the untold number of free radicals generated by the body on a daily basis?”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Your brain… weighs three pounds and has one hundred thousand miles of blood vessels. contains more connections than there are stars in the Milky Way. is the fattest organ in your body. could be suffering this very minute without your having a clue.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“cholesterol and transport it to the neuron, where it performs critically important functions.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“Sadece hareket etmek beyniniz için herhangi bir bulmacadan, matematik denkleminden,macera kitabından, hatta düşünmekten daha yararlıdır. Aerobik egzersizler sadece ömrü uzatmakla kalmaz, beynin "büyüme hormonu" olan BDNF'yi kodlayan genleri de harekete geçirir. Aerobik egzersizlerin yaşlılarda hafıza gerilemesini tersine çevirdiği ve beynin hafıza merkezinde yeni beyin hücrelerinin oluşumu artırdığı gözlemlenmiştir.”
― David Perlmutter, Grain Brain / Grain Brain Whole Life Plan / Brain Maker

“people whose blood sugar is on the high end of the “normal range” have a much greater risk for brain shrinkage.12 This ties directly into the story of type 3 diabetes.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers

“As an example, a recent report in the prestigious Archives of Internal Medicine revealed that postmenopausal women who were put on statin drugs to lower their cholesterol had a nearly 48 percent increased risk of developing diabetes compared to those who weren’t given the drug.”
― David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers