“ApoE ε2 is relatively rare, but if you inherit this allele, you’re more likely to develop Alzheimer’s disease later in life. ApoE ε3 is the most common allele, but it’s believed to neither increase nor decrease your risk. ApoE ε4, however, is the one typically mentioned in the media and feared the most. In”

David Perlmutter, Grain Brain: The Surprising Truth about Wheat, Carbs, and Sugar--Your Brain's Silent Killers
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