The End of Alzheimer's Quotes

“GOAL: Cyrex Array 5 negative.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“One way is to assess tissue transglutaminase antibodies in serum, which is a standard blood test. Another is to undergo Cyrex Array 3 testing, which evaluates antibodies to different regions of the two molecules that make up gluten. Sensitivity to rye, barley, sesame, oats, or rice—which can also cause leaky gut—can be evaluated using the Cyrex Array 4.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“it is helpful to know the status of your blood-brain barrier. The Cyrex Array 20, which evaluates the response to leaked blood-brain barrier proteins, can assess that. GOAL: Cyrex Array 20 negative.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Alzheimer’s actually reflects a protective response to many different infectious, inflammatory, or toxic insults.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Cyrex Array 2 (or other measure of gut permeability) negative.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“One of the most important contributors to Alzheimer’s disease is inflammation, and one of the most common ways to create systemic inflammation is a leaky gut.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“LDL-p (LDL particle number) = 700–1000; OR sdLDL (small dense LDL) < 20 mg/dL or < 20% of LDL; OR oxidized LDL < 60 U/l; total cholesterol > 150 (yes, more than 150, not less than).”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“When total cholesterol falls below 150, you are more likely to suffer brain atrophy—shrinking.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Why more than 99 percent of the pivotal trials of experimental Alzheimer’s drugs have failed. They targeted only one of the thirty-six contributors to the disease.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“How to give yourself Alzheimer’s. Live your life in a way that keeps your brain supplied with as many as possible of the thirty-six factors that influence whether APP gets cut into the destructive quartet or the beneficial duo.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“It comes from a protective response to inflammatory insults (such as infections or trans fats), suboptimal nutrients, trophic factors, and/or hormone levels, or toxic compounds (including biotoxins, such as those from mold or bacteria) that cause the APP receptor—the long molecule that protrudes from neurons—to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“SirT1, a molecule that has been linked to longevity and, as mentioned above, has an anti-Alzheimer’s effect. (Resveratrol, a compound in red wine, activates the SirT1 protein.)”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“(Resveratrol, a compound in red wine, activates the SirT1 protein.)”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“ApoE4 causes a person’s risk of developing the disease to soar.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“regimen based in large part on diet, exercise, sleep, stress reduction, and other lifestyle factors.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“The clinical trial system is just not set up to test a comprehensive program like ReCODE. But the bench research had pointed us in the right direction, showing us that a personalized, targeted, precision medicine approach to Alzheimer’s disease makes far more sense than a one-size-fits-all, monotherapy approach.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“During this struggle I could not help thinking about the birth of functional medicine, in which a physician determines the root causes of illnesses and treats all contributing factors. Drs. Jeffrey Bland, David Jones, David Perlmutter, Mark Hyman—starting about two decades ago, they began treating complex chronic problems like type 2 diabetes, lupus, and obesity with unprecedented success. Yet medical schools had virtually no interest in teaching about this approach. As the pioneers of functional medicine discovered, you know you are doing something that is paradigm changing when you are doing it right in front of everyone but no one can see it.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“By 2011 we had discovered that no fewer than thirty-six molecular mechanisms contribute to Alzheimer’s.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“dramatic reductions in the prevalence of dementia could be achieved if more people underwent genetic testing to determine their ApoE status and initiated a preventive program long before any symptoms appeared.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“the people who carry a gene variant (allele) called ApoE4 (ApoE is short for apolipoprotein E; an apolipoprotein is a protein that carries lipids—i.e., fats). ApoE4 is the strongest known genetic risk factor* for Alzheimer’s disease. Carrying one ApoE4 (that is, inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent, while carrying two copies (inheriting copies from both parents) increases it to well over 50 percent (from 50 to 90 percent, depending on which study you read). That compares to a risk of only about 9 percent in people who carry zero copies of this allele.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“there are steps we can all take now to prevent the cognitive decline that experts have long believed to be unavoidable and irreversible.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Alzheimer’s is not a single disease.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“these three readily distinguishable subtypes are each driven by different biochemical processes. Each one requires a different treatment. Treating them all the same way is as naive as treating every infection with the same antibiotic.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“it is the only one—let me repeat that: the only one—of the nation’s ten most common causes of death for which there is no effective treatment.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Incredibly, given the astounding progress in other areas of medicine over the last twenty years—think cancer or HIV/AIDS or cystic fibrosis or cardiovascular disease—as I write this in 2017 not only is there no cure for Alzheimer’s disease, there is not even anything that reliably prevents or slows Alzheimer’s disease.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“You never change things by fighting the existing reality. To change something, build a new model that makes the existing model obsolete. —R. BUCKMINSTER FULLER”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“marked atrophy of her hippocampus. It had shrunk so much that it was smaller than 99 percent of hippocampi of people her age. That is a dire sign for someone with Alzheimer’s symptoms. Her evaluation”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Contrary to the current dogma, therefore, what is referred to as Alzheimer’s disease is actually a protective response to, specifically, three different processes: inflammation, suboptimal levels of nutrients and other synapse-supporting molecules, and toxic exposures.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Alzheimer’s disease can be prevented, and in many cases its associated cognitive decline can be reversed.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline

“Take a standard thermometer, shake it down, and place it next to your bed before you go to sleep for the night. Before getting out of bed in the morning, place the thermometer in your armpit for 10 minutes. It should read between 97.8 degrees and 98.2 degrees Fahrenheit. If it is lower, you likely have low thyroid function.”
― Dale Bredesen, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline