The Role of Histamine and Mast Cells in PMS and PMDD

Here’s something important about PMS or PMDD (premenstrual dysphoric disorder): At least some of the time it’s caused or worsened by histamine or mast cell activation

Histamine can cause allergy-type symptoms such as hives and nasal congestion. Or it can cause anxiety, headaches, fatigue, brain fog, insomnia, and breast tenderness, the typical symptoms of PMS.

How histamine causes premenstrual symptoms

It makes sense that histamine can cause premenstrual symptoms. After all, histamine is pro-...