Jeffrey Dach's Blog, page 23

April 5, 2016

Bioidentical Hormones Opposed by Endocrine Society

The Endocrine Society Makes a “Proclamation”

The Endocrine Society issued a “scientific statement” advising rank and file physicians to cease and desist prescribing compounded bioidentical hormones to the tune of one billion dollars a year.(1)

That’s a lot of compounding, and no doubt a big bite out of Big Pharma’s bottom line, I have a better idea, let’s change the name of the Endocrine Society to the Endocrine Nonsense Society. If we were to follow the Endocrine society’s proclamation to its logical conclusion, we would be forced to close down all hospital pharmacies, since they are compounding pharmacies. Nope, I don’t think so. Compounding is here to stay.

In most of these Endocrine Society Decrees, subservience to the pharmaceutical industry agenda is more opaque. This one is blatantly obvious and reminiscent of a scene in a Woody Allen movie, Bananas. The new Dictator’s first proclamation is “all subjects are to wear their underwear on the outside”. Oh well, Just another day for George Orwell’s “Ministry of Health and Truth”. America, it’s a Great Country.. See video below:

Jeffrey Dach MD

Links and References

1) Endocrine Society Advises Against Compounded Hormone Use

The post Bioidentical Hormones Opposed by Endocrine Society appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on April 05, 2016 04:56

March 30, 2016

Vaxxed Documentary Exposes Fraud at CDC

Vaxxed Documentary

Exposes Fraud at CDC

Robert DeNiro made big news when he announced inclusion of the documentary film, Vaxxed at the Tribeca Film Festival.

Robert De Niro explained he has a child with autism, and wanted a “conversation” about the vaccine-autism link. Apparently succumbing to threats from “Pharmaceutical Industry Goons”, De Niro later quickly retracted his position and removed the film from the Tribeca Festival Opening, revealing the power of the drug/vaccine industry.

Victory for Freedom of Speech

In a major victory for freedom of speech against heavy handed totalitarian censorship, Cinema Libre Studio has announced it will distribute the controversial documentary “Vaxxed: From Cover-Up to Catastrophe,” (1)

Fraud and Cover-Up at the CDC

The documentary Vaxxed reveals how William Thompson, a CDC Whistleblower, admitted in 2014 that a study published ten years earlier in 2004 by DeStefano was falsified to remove a link between MMR vaccine and autism in African American children.

David Brownstein MD Blog

Dr David Brownstein informs us:

“It has been 15 months since a senior CDC scientist, Dr. William Thompson, became a whistleblower when he admitted that a 2004 CDC study was falsified in order to show that there was no link between the MMR vaccine and autism. In August of 2014 Dr. Thompson stated, “I regret that my coauthors and I omitted statistically significant information in our 2004 DeStefano article published in the Journal of Pediatrics.”(3)

Not the First Time

As documented nicely by Neil Miller’s Minority Report, this is not the first time the Measles vaccine has run into trouble. (10)

A previous study published in 1993 done on African children with the E-Z measles vaccine showed increased mortality in female children receiving the vaccine compared to placebo. (16)

Houston, We Have a Problem

Another vaccine safety problem was discovered with the oral poiio vaccine, which I personally received as a child in the 1950’s. Forty years later, in 1993, it was discovered that attenuated polio vaccine reverts to its neuro-virulent form. In other words, the polio vaccine mutates back into its original form and causes polio. This is the reason why the CDC discontinued use of the live oral vaccine fifteen year ago in the US (in 2000), and switched to the killed inject-able Salk vaccine. See my previous article on this: The Failure of Global Polio Eradication.

Watch the Original Uncensored Interview

In another victory of truth over censorship, watch the original uncensored ABC news interview with Del Bigtree, producer of Vaxxed.

VAXXED: the ABC News interview that Big Pharma didn’t want you to see

Courtesy of TheHealthRanger

Film Opens in New York City

Exclusive One Week Engagement – Friday, April 1st, 2016

Angelika Film Center

18 W. Houston St., New York, NY 10012

(212) 995-2570

Show times: Friday (4/1) thru Thursday (4/7): 11:00a, 1:15p, 3:30p, 5:45p, 8:00p, 10:30p

Tickets can be purchased through Fandango.

Articles With Related Interest

The Failure of Global Polio Eradication

Spraying DDT to Eradicate Polio

Which is Greater Threat Measles, or the Measles Vaccine ?

Dissolving Illusions by Suzanne Humphries

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

Links and References:

1) http://variety.com/2016/film/news/vaxxed-anti-vaccine-documentary-cinema-libre-1201741603/

Controversial Anti-Vaccination Documentary Gets Release From Cinema Libre (EXCLUSIVE)

Film Reporter Dave McNary Variety

Cinema Libre Studio has announced it will distribute the controversial documentary “Vaxxed: From Cover-Up to Catastrophe,” Variety has learned exclusively.

The distributor’s announcement came late Tuesday, three days after the Tribeca Film Festival pulled “Vaxxed” from its lineup with festival co-founder Robert De Niro explaining it did not contribute to or further the discussion he had hoped for about issues surrounding autism.

The documentary will premiere Friday at the Angelika FiIm Center in New York City. Cinema Libre has not revealed future distribution plans other than saying it will be “widely released” in other cities.

2) http://truthbarrier.com/2016/03/30/breaking-news-cinema-libre-to-distribute-vaxxed-we-chose-to-distribute-this-film-to-correct-a-major-issue-which-is-the-suppression-of-medical-data-by-a-governmental-agency-that-may-very-we/

LOS ANGELES, CA (March 29, 2016) Cinema Libre Studio will be distributing Vaxxed: From Cover-Up to Catastrophe, the explosive documentary directed by Andrew Wakefield which was “de-selected” from the Tribeca Film Festival this past weekend.

3) http://blog.drbrownstein.com/1029-2/

CDC Cover-Up of Autism and Vaccine Link Continues by David Brownstein MD

It has been 15 months since a senior CDC scientist, Dr. William Thompson, became a whistleblower when he admitted that a 2004 CDC study was falsified in order to show that there was no link between the MMR vaccine and autism. In August of 2014 Dr. Thompson stated, “I regret that my coauthors and I omitted statistically significant information in our 2004 article published in the Journal of Pediatrics.”

4) http://www.autismfile.com/uncategorized/vaxxed-the-powerful-new-documentary-the-cdc-wishes-would-just-go-away

Vaxxed: The powerful new documentary the CDC wishes would just go away Posted on March 26, 2016 by Mollie Shreffler

Del Bigtree collaborating with Dr. Andrew Wakefield in producing the documentary Vaxxed: From Cover-up to Catastrophe. Vaxxed has been accepted into the 2016 Tribeca Film Festival and is scheduled to be shown on Sunday, April 24 with its New York premiere set for the first week in June. Autism File executive editor Rita Shreffler spoke with Mr. Bigtree recently on the challenges in bringing the truth about vaccine injury and CDC autism research fraud into the mainstream consciousness.

5) Del Bigtree Producer of Vaxxed Cecnsored Interview with ABC News

VAXXED: the ABC News interview that Big Pharma didn’t want you to see

TheHealthRanger

https://www.youtube.com/embed/tvcdh7KlgPI” frameborder=”0″ allowfullscreen>

6) http://anhinternational.org/2016/03/23/16295/

“VAXXED From Cover-up to Catastrophe”

The US Centers for Disease Control and Prevention’s (CDC) own figures reveal the shocking and disturbing fact that the prevalence of autism more than doubled between 2000 and 2010. According to Doreen Granpeesheh PhD, founder of the Centre for Autism and Related Disorders, 1 in 15,000 children developed autism in 1978, but the risk is currently sitting on average at 1 in every 25 children.

Researcher Stephanie Seneff PhD from MIT says if things continue this way “we can predict that by 2032, 80% of the boys born will end up on the autism spectrum. Half the children, 80% of the boys. This is going to be a complete catastrophe if we just let it happen”.

However, in 2014, Brian Hooker PhD, father of an autistic child, took a fresh look at CDC data, and discovered that they had hidden a 340% increase in autism among African-American kids given the vaccine before 36 months. CDC whistleblower/senior scientist Dr William Thompson came forward to confirm a scandalous CDC cover-up, —a matter that has subsequently been raised in Congress by REP Bill Posey,

7) http://www.forbes.com/sites/emilywillingham/2015/08/06/a-congressman-a-cdc-whisteblower-and-an-autism-tempest-in-a-trashcan/#16fda27c385e

Aug 6, 2015

A Congressman, A CDC Whisteblower And An Autism Tempest In A Trashcan Emily Willingham Forbes

—————————–

8) Hooker, Brian S. “Measles-mumps-rubella vaccination timing and autism among young african american boys: a reanalysis of CDC data.” Translational neurodegeneration 3.1 (2014): 1.

Editor’s Note: This article has been retracted. The retraction notice can be found here.

Conclusions: The present study provides new epidemiologic evidence showing that African American males receiving the MMR vaccine prior to 24 months of age or 36 months of age are more likely to receive an autism diagnosis.

9) Measles mumps rubella vaccination autism Pediatrics 2004 DeStefano Frank DeStefano, Frank, et al. “Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan Atlanta.” Pediatrics 113.2 (2004): 259-266.

10) CDC Fraud and Cover Up Brian Hooker WIlliam Thompson Vaxxed_Minority_Report_2014 _Neil Miller Miller, Neil Z. “Minority Report: A Covert CDC Program Inoculated Black Babies.”

11) Garenne, Michel, et al. “Child mortality after high-titre measles vaccines: prospective study in Senegal.” The Lancet 338.8772 (1991): 903-907.

12) BERRY, SUSAN, et al. “Comparison of high titer Edmonston-Zagreb, Biken-CAM and Schwarz measles vaccines in Peruvian infants.” The Pediatric infectious disease journal 11.10 (1992): 822-827.

13) Kiepiela, P., et al. “Lack of efficacy of the standard potency Edmonston-Zagreb live, attenuated measles vaccine in African infants.” Bulletin of the World Health Organization 69.2 (1991): 221.

14) Jensen, Thøger Gorm, et al. “Trials of Edmonston-Zagreb measles vaccine in Guinea-Bissau: serological responses following vaccination with Edmonston-Zagreb strain at 4–8 months versus vaccination with Schwarz strain at 9–12 months of age.” Vaccine 12.11 (1994): 1026-1031.

15) George, Kuryan, et al. “Measles vaccination before nine months.” Tropical Medicine & International Health 3.9 (1998): 751-756.

16) Aaby, Peter, et al. “Long-term survival after Edmonston-Zagreb measles vaccination in Guinea-Bissau: increased female mortality rate.” The Journal of pediatrics 122.6 (1993): 904-908.

Girls in the EZ group had significantly higher mortality rates than girls in the control group (mortality ratio = 1.95; range, 1.07 to 3.56; p = 0.027);

Header Image courtesy of Vaccine Risk Awareness.

link to this article: http://wp.me/p3gFbV-3v6

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

www.jeffreydachmd.com

http://www.drdach.com

http://www.naturalmedicine101.com

http://www.bioidenticalhormones101.com

http://www.truemedmd.com

Disclaimer click here: http://www.drdach.com/wst_page20.html

The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.

Serving Areas of: Hollywood, Aventura, Miami, Fort Lauderdale, Pembroke Pines, Miramar, Davie, Coral Springs, Cooper City, Sunshine Ranches, Hallandale, Surfside, Miami Beach, Sunny Isles, Normandy Isles, Coral Gables, Hialeah, Golden Beach ,Kendall,sunrise, coral springs, parkland,pompano, boca raton, palm beach, weston, dania beach, tamarac, oakland park, boynton beach, delray,lake worth,wellington,plantation.

The post Vaxxed Documentary Exposes Fraud at CDC appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on March 30, 2016 06:02

March 25, 2016

Tylenol Acetaminophen Liver Toxicity by Jeffrey Dach MD

Tylenol Acetaminophen

Liver Toxicity

by Jeffrey Dach MD

Rebecca is a 46 year old CEO of a large manufacturing company and arrives in my office with a chief complaint of low back pain for which she takes Extra Strength Tylenol for the past 4 years ( Acetaminophen – Three 500mg tablets three times daily) for a daily dosage of 4500 mg Acetaminophen). Left image: courtesy of WakeMed Pharmacy.

I explained to Rebecca that Tylenol consumption is the main cause of Liver failure requiring liver transplantation in the United States and Great Britain. Liver damage is additive by combining alcohol consumption with Tylenol. So far, Rebecca has been lucky, and has not suffered liver damage as an adverse side effect of Tylenol. Left Image Courtesy of wikimedia commons.

I explained to Rebecca that her Liver converts the Acetaminophen into a toxic metabolite called N-acetyl-p-benzoquinonimine (NAPQI). This NAPQI depletes the liver cells of glutathione, our most important intracellular anti-oxidant.

According to Dr Jack Hinson in a 2010 report, this loss of glutathione in the liver cells leads to initiation of mitochondrial damage with inability to synthesize ATP, our main source of cellular energy. Loss of ATP causes massive hepatic necrosis (liver cell death).(4)

Left Image: FDA Warning for Acetaminophen.

Antidote to Tylenol Poisoning is NAC

Restoring glutathione levels with NAC (N-acetyl cysteine) is the antidote to Tylenol induced liver damage. Dr David Brownstein also recommends (ALA) Alpha Lipoic Acid and Vitamin c to protect the liver from acetaminophen toxicity. (10) Dr Brownstein also advises against using Tylenol in infants after vaccination, or in infants with fever.(10) Left Image Tylenol label courtesy of WIkimedia Commons.

Ineffective for Low Back Pain

A recent report by Dr Gustavo Machado in 2015 BMJ ,concluded: ” Paracetamol (acetaminophen) is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis.”(12)

Alternatives to T ylenol

There are many safer alternatives to Tylenol (Acetaminophen) for reduction of musculoskeletal inflammation and pain relief. Botanicals such as Boswellia, Curcumin, and Berberine are all good alternatives.

Articles With Related Interest:

NSAIDS Small Bowel and Leaky Gut

Berberine Antidote for an Epidemic

Jeffrey Dach MD

Links and References

Acetaminophen toxicity

1) http://www.cnn.com/2014/01/15/health/fda-acetaminophen-dosage/

FDA: Acetaminophen doses over 325 mg might lead to liver damage By Holly Yan, CNN

2) Acetaminophen toxicity mitochondrial damage hepatocytes J Biol Chem1991 Burcham J Biol Chem. 1991 Mar 15;266(8):5049-54.

Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. Burcham PC1, Harman AW. 1Department of Pharmacology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands.

Exposure of isolated mouse hepatocytes to a toxic concentration of acetaminophen (5 mM) resulted in damage to the mitochondrial respiratory apparatus. The nature of this damage was investigated by measuring respiration stimulated by site-specific substrates in digitonin-permeabilized hepatocytes after acetaminophen exposure. Respiration stimulated by succinate at energy-coupling site 2 was most sensitive to inhibition and was decreased by 47% after 1 h. Respiration supported by NADH-linked substrates (site 1) was also decreased but to a lesser extent, while there was no decrease in the rate of ascorbate N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD)-supported respiration (site 3). The loss of mitochondrial respiratory function was accompanied by a decrease in ATP levels and ATP/ADP ratios in the cytosolic compartment and was preceded by a loss of reduced glutathione in both the cytosol and mitochondria. All these effects occurred well before the loss of cell membrane integrity. The putative toxic metabolite of acetaminophen, N-acetyl-p-benzoquinonimine (NAPQI), produced a similar pattern of respiratory dysfunction in isolated hepatic mitochondria. Respiration stimulated by succinate- and NADH-linked substrates was very sensitive to 50 microM NAPQI, while ascorbate TMPD-supported respiration was unaffected. The interaction between NAPQI and the respiratory chain was further investigated using submitochondrial particles. Succinate dehydrogenase (associated with respiratory complex II) was found to be very sensitive to NAPQI, while NADH dehydrogenase (respiratory complex I) was inhibited to a lesser extent. Our results indicate that a loss of the ability to utilize succinate- and NADH-linked substrates due to attack of the respiratory chain by NAPQI causes a disruption of energy homeostasis in acetaminophen hepatotoxicity.

2005

3) http://www.journal-of-hepatology.eu/article/S0168-8278(04)00429-5/fulltext?mobileUi=0

Masubuchi, Yasuhiro, Chieko Suda, and Toshiharu Horie. “Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.” Journal of hepatology 42.1 (2005): 110-116.

toxicity has been shown to be initiated by cytochrome P450 metabolism to N-acetyl-p-benzoquinone imine (NAPQI) [[1], [2]]. The high reactivity of NAPQI with sulfhydryl groups results in depleting glutathione in hepatocytes, followed by covalent binding to intracellular proteins

Mitochondrial permeability transition (MPT) is recently focused as a mechanism for drug-induced hepatocyte injury [[16], [17], [18]]. The MPT represents an abrupt increase in permeability of the mitochondrial inner membrane to allow solutes with a molecular weight less than 1500 [19]. The MPT is promoted by the accumulation of excessive Ca2 and stimulated by various compounds and conditions. It leads to dissipation of membrane potential (Δψ), uncoupling of oxidative phosphorylation, loss of pre-accumulated Ca2 , and expansion of the matrix volume. MPT causes both apoptotic and necrotic cell death.

2010

4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836803/?tag=stupide-21

Hinson, Jack A., Dean W. Roberts, and Laura P. James. “Mechanisms of acetaminophen-induced liver necrosis.” Adverse Drug Reactions. Springer Berlin Heidelberg, 2010. 369-405.

the hepatotoxicity of acetaminophen appears to occur by a complex mechanistic sequence (Fig. 3). These events include:

(1) CYP metabolism to the reactive metabolite NAPQI which depletes glutathione by a conjugation reaction and covalently binds to proteins;

(2) loss of glutathione causing an increased oxidative stress response (decreased detoxification of reactive oxygen and nitrogen species);

(3) increased oxidative stress, possibly associated with alterations in calcium metabolism, initiation of signal transduction responses and mitochondrial permeability transition;

(4) mitochondrial permeability transition occurring with an even larger increase in oxidative stress, loss of mitochondrial membrane potential, and loss of the ability of the mitochondria to synthesize ATP; and

(5) loss of ATP which causes necrosis.

Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for approximately one-half of all cases of acute liver failure in the United States and Great Britain today.

each week approximately 50 million adults in the United States take acetaminophen-containing products.

Reaction of NAPQI with glutathione occurs by conjugation to form 3-glutathion-S-yl-acetaminophen and by reduction to acetaminophen

reactive metabolite of acetaminophen was identified to be N-acetyl-p-benzoquinone imine (NAPQI). It was found to be formed by cytochrome P-450 (CYP) by a direct two electron oxidation of acetaminophen

In initial work describing the importance of hepatic glutathione in acetaminophen-induced hepatotoxicity in mice, Mitchell et al. (1973a, b) showed that administration of cysteine prevented hepatotoxicity. This finding led to the development of N-acetyl-cysteine (available as Mucomyst®) as the preferred antidote

N-acetylcysteine inhibits acetaminophen toxicity has been postulated to be increased detoxification of NAPQI by a direct conjugation or through increased glutathione synthesis

NAC antidote to acetamenophen live toxicity

2008 full pdf

5) Algren, D. Adam. “Review of N-acetylcysteine for the treatment of acetaminophen (paracetamol) toxicity in pediatrics.” Second Meeting of the Subcommittee of the Expert Committee on the Selection and Use of Essential Medicines. Vol. 29. 2008.

2015

6) http://www.ncbi.nlm.nih.gov/pubmed/25537186

Arch Toxicol. 2015 Feb;89(2):193-9. doi: 10.1007/s00204-014-1432-2. Epub 2014 Dec 24. Acetaminophen hepatotoxicity: an updated review.

Lancaster EM1, Hiatt JR, Zarrinpar A.

As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-induced hepatotoxicity remains a significant public health concern and common indication for emergent liver transplantation. This problem is largely attributable to acetaminophen combination products frequently prescribed by physicians and other healthcare professionals, with unintentional and chronic overdose accounting for over 50 % of cases of acetaminophen-related ALF. Treatment with N-acetylcysteine can effectively reduce progression to ALF if given early after an acute overdose; however, liver transplantation is the only routinely used life-saving therapy once ALF has developed. With the rapid course of acetaminophen-related ALF and limited supply of donor livers, early and accurate diagnosis of patients that will require transplantation for survival is crucial. Efforts in developing novel treatments for acetaminophen-induced ALF are directed toward bridging patients to recovery. These include auxiliary, artificial, and bioartificial support systems. This review outlines the most recent developments in diagnosis and management of acetaminophen-induced ALF.

7) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652821/

Chen, Yu-Guang, et al. “Risk of Acute Kidney Injury and Long-Term Outcome in Patients With Acetaminophen Intoxication: A Nationwide Population-Based Retrospective Cohort Study.” Medicine 94.46 (2015).

8) diagram of biochemical pathways

https://www.pharmgkb.org/pathway/PA166117881

Acetaminophen Pathway (toxic doses), Pharmacokinetics

2012

9) http://tbiomed.biomedcentral.com/articles/10.1186/1742-4682-9-55

Ben-Shachar, Rotem, et al. “The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model.” Theoretical Biology and Medical Modelling 9.1 (2012): 55.

Acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for 56,000 emergency room visits per year. The standard treatment for overdose is N-acetyl-cysteine (NAC), which is given to stimulate the production of glutathione.

10) Just Say No To Acetaminophen

Also, it is best to support the liver with the proper supplements when using acetaminophen. This can include taking vitamin C (3-6,000mg/day), N-acetyl cysteine (300-600mg/day), and alpha lipoic acid (3-600mg/day).

11) Roberts, Emmert, et al. “Paracetamol: not as safe as we thought? A systematic literature review of observational studies.” Annals of the rheumatic diseases (2015): annrheumdis-2014.

12) Machado, Gustavo C., et al. “Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials.” bmj 350 (2015): h1225.

conclusion: Paracetamol is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis. These results support the reconsideration of recommendations to use paracetamol for patients with low back pain and osteoarthritis of the hip or knee in clinical practice guidelines.

13) New FDA Steps Aimed at Cutting Risks from Acetaminophen

Sandra Kweder, M.D., deputy director of FDA’s Office of New Drugs, says the agency’s most recent action is aimed at making pain medications containing acetaminophen safer for patients to use.

“Overdoses from prescription products containing acetaminophen account for nearly half of all cases of acetaminophen-related liver failure in the U.S., many of which result in liver transplant or death,” says Kweder.

Most of the cases of severe liver injury occurred in patients who

took more than the prescribed dose of an acetaminophen-containing product in a 24-hour period took more than one acetaminophen-containing product at the same time drank alcohol while taking the drug

link to this page:http://wp.me/p3gFbV-3tu

Disclaimer click here: http://www.drdach.com/wst_page20.html

The post Tylenol Acetaminophen Liver Toxicity by Jeffrey Dach MD appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on March 25, 2016 04:18

January 27, 2016

Protected: Mantle Cell Lymphoma Stepping Up to the Plate

This content is password protected. To view it please enter your password below:

Password:

The post Protected: Mantle Cell Lymphoma Stepping Up to the Plate appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on January 27, 2016 07:07

December 31, 2015

Colostrum Three Times More Effective Than Flu Vaccine

Colostrum Three Times More Effective Than Flu Vaccine

by Jeffrey Dach MD

Dr Maria Cesarone from Italy published her study in 2007 in which she compared the efficacy of oral colostrum to that of influenza vaccination in preventing flu illness. Dr Cesarone found a two month treatment with oral colostrum was three times more effective in preventing flu illness than was influenza vaccination.(1-2) Left image courtesy of bovine colostrum.

What is Colostrum ?

Colostrum is the first 24-48 hours of milk produced by the cow after the calf is born, and contains immune system and growth factors needed by the calf. If the calf does not receive mother’s colostrum within 24 to 48 hours after birth, the calf will die. Bovine colostrum is similar to human colostrum. Left Image courtesy of Embryology UNSW.

Mouse Model Shows Colostrum Stimulates Immune System

In a mouse model of influenza published by Dr. Wong in 2014, the authors found:

“Colostrum supplementation enhanced NK cell cytotoxicity and improved the immune response to primary influenza virus infection in mice.”….

“Colostrum-supplemented mice demonstrated less reduction in body weight after influenza infection, indicating a less severe infection, increased NK cell cytotoxicity, and less virus burden in the lungs compared with controls.”. (3)

In this study, bovine colostrum, which contains approximately 500 g of IgG per milking per animal, has been investigated as a source of polyclonal antibody for delivery to the respiratory tract. IgG and F(ab’)2 were purified from the hyperimmune colostrum of cows vaccinated with influenza A/Puerto Rico/8/34 (PR8) vaccine and were shown to have high hemagglutination-inhibitory and virus-neutralizing titers. In BALB/c mice, a single administration of either IgG or F(ab’)2 could prevent the establishment of infection with a sublethal dose of PR8 virus when given as early as 7 days prior to exposure to virus. Pre-treated mice also survived an otherwise lethal dose of virus, the IgG- but not the F(ab’)2-treated mice showing no weight loss. Successful reduction of established infection with this highly virulent virus was also observed with a single treatment 24 hr after virus exposure.

Influenza Immunity Obtained From Hyper Immune Colostrum

In this article, the authors immunized cows with a virulent influenza virus, and the subsequent colostrum contained high titers of anti-viral antibodies. When mice where given this hyper-immune colostrum, the antibodies were transferred from the colostrum to the mice, who were then protected from this virulent strain of influenza virus.(10)

Buy Colostrum on Amazon site.

Articles with Related Interest:

NSAIDS, Small Bowel and Leaky Gut

Vitamin D Prevents Flu

Jeffrey Dach MD

Links and References

1) Cesarone, Maria Rosaria, et al. Prevention of Influenza With Colostrum Compared with Vaccination in Healthy and High-Risk Cardiovascular Subjects The Epidemiologic Study in San Valentino.” Clinical and Applied Thrombosis/Hemostasis 13.2 (2007): 130-136.

2) Clin Appl Thromb Hemost. 2007 Apr;13(2):130-6.

Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Cesarone MR1, Belcaro G, Di Renzo A, Dugall M, Cacchio M, Ruffini I, Pellegrini L, Del Boccio G, Fano F, Ledda A, Bottari A, Ricci A, Stuard S, Vinciguerra G.

The efficacy of a 2-month treatment with oral colostrum in the prevention of flu episodes compared with antiinfluenza vaccination was evaluated. Groups included healthy subjects without prophylaxis and those receiving both vaccination and colostrum. After 3 months of follow-up, the number of days with flu was 3 times higher in the non-colostrum subjects. The colostrum group had 13 episodes versus 14 in the colostrum + vaccination group, 41 in the group without prophylaxis, and 57 in nontreated subjects. Part 2 of the study had a similar protocol with 65 very high-risk cardiovascular subjects, all of whom had prophylaxis. The incidence of complications and hospital admission was higher in the group that received only a vaccination compared with the colostrum groups. Colostrum, both in healthy subjects and high-risk cardiovascular patients, is at least 3 times more effective than vaccination to prevent flu and is very cost-effective…

anti-influenza mouse model

3) Nutr Res. 2014 Apr;34(4):318-25. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4.

Wong EB1, Mallet JF2, Duarte J2, Matar C2, Ritz BW3.

Oral administration of bovine colostrum affects intestinal immunity, including an increased percentage of natural killer (NK) cells. However, effects on NK cell cytotoxic activity and resistance to infection as well as a potential mechanism remain unclear. Therefore, we investigated the effects of bovine colostrum (La Belle, Inc, Bellingham, WA) on the NK cytotoxic response to influenza infection and on toll-like receptor (TLR) activity in a primary intestinal epithelial cell culture. We hypothesized that colostrum would increase NK cell activity and that TLR-2 and TLR-4 blocking would reduce interleukin 6 production by epithelial cells in response to contact stimulation with colostrum. Four-month-old female C57BL/6 mice were supplemented with 1 g of colostrum per kilogram of body weight before and after infection with influenza A virus (H1N1). Animals were assessed for weight loss, splenic NK cell activity, and lung virus titers. Colostrum-supplemented mice demonstrated less reduction in body weight after influenza infection, indicating a less severe infection, increased NK cell cytotoxicity, and less virus burden in the lungs compared with controls. Colostrum supplementation enhanced NK cell cytotoxicity and improved the immune response to primary influenza virus infection in mice. To investigate a potential mechanism, a primary culture of small intestine epithelial cells was then stimulated with colostrum. Direct activation of epithelial cells resulted in increased interleukin 6 production, which was inhibited with TLR-2 and TLR-4 blocking antibodies. The interaction between colostrum and immunity may be dependent, in part, on the interaction of colostrum components with innate receptors at the intestinal epithelium, including TLR-2 and TLR-4.

4) Bovine colostrum in clinical medicine_2007_W G Struff_II

5) Bovine Colostrum for Chronic Pain Doug Wyatt

6) Anti_Aging Benefits of Bovine Colostrum Doug Wyatt

7) Bovine Colostrum and Athletic Performance Doug Wyatt

8) Bovine Colostrum and Infant Health Doug Wyatt

9) Bovine Colostrum and Immune Modulation_PRPs_Townsend_Doug_Wyatt

10)

PLoS One. 2010 Oct 26;5(10):Prevention and treatment of influenza with hyperimmune bovine colostrum antibody.

Ng WC1, Wong V, Muller B, Rawlin G, Brown LE.

BACKGROUND: Despite the availability of specific vaccines and antiviral drugs, influenza continues to impose a heavy toll on human health worldwide. Passive transfer of specific antibody (Ab) may provide a useful means of preventing or treating disease in unvaccinated individuals or those failing to adequately seroconvert, especially now that resistance to antiviral drugs is on the rise. However, preparation of appropriate Ab in large scale, quickly and on a yearly basis is viewed as a significant logistical hurdle for this approach to control seasonal influenza.

METHODOLOGY/PRINCIPAL FINDINGS:In this study, bovine colostrum, which contains approximately 500 g of IgG per milking per animal, has been investigated as a source of polyclonal antibody for delivery to the respiratory tract. IgG and F(ab’)2 were purified from the hyperimmune colostrum of cows vaccinated with influenza A/Puerto Rico/8/34 (PR8) vaccine and were shown to have high hemagglutination-inhibitory and virus-neutralizing titers. In BALB/c mice, a single administration of either IgG or F(ab’)2 could prevent the establishment of infection with a sublethal dose of PR8 virus when given as early as 7 days prior to exposure to virus. Pre-treated mice also survived an otherwise lethal dose of virus, the IgG- but not the F(ab’)2-treated mice showing no weight loss. Successful reduction of established infection with this highly virulent virus was also observed with a single treatment 24 hr after virus exposure.

CONCLUSIONS/SIGNIFICANCE:These data suggest that a novel and commercially-scalable technique for preparing Ab from hyperimmune bovine colostrum could allow production of a valuable substitute for antiviral drugs to control influenza with the advantage of eliminating the need for daily administration.

link to this page:http://wp.me/p3gFbV-3kO

Disclaimer click here: http://www.drdach.com/wst_page20.html

The post Colostrum Three Times More Effective Than Flu Vaccine appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on December 31, 2015 09:55

December 26, 2015

Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie Fl 33314

Office Address: Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie Fl 33314. 954-792-4663. Listing.

Office Front View Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie Florida

The post Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie Fl 33314 appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on December 26, 2015 16:02

December 18, 2015

Philippines Supreme Court Bans GMO Genetically Modified Food

Phillines Supreme Court Bans GMO Genetically Modified Food

by Jeffrey Dach MD

In a major victory for the people against evil GMO corporations like Monsanto, the Phillipines Supreme Court ruling effectively banned GMO food from the Phillipine Islands.(1-2)Â GMO food is inherently unhealthy and dangerous to our environment, and should be banned by all countries interested in preserving the health of their citizens. Left image courtesy of Christina Sarich (3)

Above image courtesy of DR. MICHAEL PURUGGANAN (4).

For articles with related interest:

Genetically Modified Food the Great Scandal

Genetically Modified GMO Food Part 2

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

Links and References

1) NO GMO crop trials in Philippines says Supreme Court By Karen Graham Dec 14, 2015 in Environment Digital Journal

“The Supreme Court of the Philippines has ordered a permanent ban on field trials of GM eggplant, and a temporary halt to approving applications âcontained use, import, commercialization and propagationâ of GMO crops and products.”

2) GreenPeace-
Philippinesâ Supreme Court bans development of genetically engineered products

11 December, 2015 at 6:16 – Manila, 11 December 2015 – The Supreme Court of the Philippines has ordered a permanent ban on field trials of genetically engineered (GE) eggplant and a temporary halt on approving applications for the âcontained use, import, commercialisation and propagationâ of GE crops, including the import of GE products.

3)Â Farmers of the Philippines Say âNo Wayâ to GMO Rice

“There are other fixes for vitamin A deficiency by Christina Sarich April 25, 2015

Â 4) Who’s afraid of the GMO eggplant? May 27, 2013 By DR. MICHAEL PURUGGANAN

The post Philippines Supreme Court Bans GMO Genetically Modified Food appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on December 18, 2015 07:26

December 16, 2015

More Lies about Bioidentical Hormones

More Lies about Bioidentical Hormones

by Jeffrey Dach MD

Bioidentical Hormones are under attack again from Medscape, something one might expect from an online medical information site funded by the major drug companies. (1)Â This time, the lies about bioidentical hormones come from an appropriately named Dr. Lie, who, by the way is a recipient of sizable funds from Merck, maker of women’s hormone products Nuvaring and Nexplanon. (4-10) Both products contain etonogestrel, a chemically altered version of progesterone which does not occur anywhere in nature or in the human body.(2,3)Â Altering the chemical structure of the ovarian hormone progesterone, creates a “Monster Hormone”,Â causing cancer and heart disease.Â This is not a good idea.Â For example, a cousin of etonogestrel, medroxy-progesterone was found to cause breast cancer and heart disease in the ill-fated Womens Health Initiative Study published in 2002 in JAMA.(11). Left image Hormone Therapy Courtesy of ANH.

No Studies on Etonorgestrel and Breast Cancer

You might therefore ask the question: Does etonorgestrel cause breast cancer? Since the drug is “FDA approved”, one might mistakenly think this has been thoroughly studied.Â The FDA approved patient label will set you straight.Â It has never been studied. Here is a quote from the product label for Nexplanon, the implantable etonorgestrol product by Merck:

“It is not known whether NEXPLANON use changes a womanâs risk for breast cancer.” quote from FDA approved label (13)

Firstly, Dr Lie laments that in spite of guidelines created by medical organizations funded by the major drug companies advising women to use their “FDA approved” synthetic hormone products, nonetheless, women and their physicians have rejected these guidelines and switched in large numbers to bioidentical hormones, identical to those made by the human ovary.

Rebellious Physicians Refuse to Cooperate

Jeffrey Dach MD Bioidentical Hormones

Could it be possible that some rebellious physicians refuse to cooperate with “Big Pharma”, revealing a callous disregard for authority ?Â Â Â No, this couldn’t be possible.Â It must be the doctor’s lack of training on using the proper phrases and arguments in a conversation with the patient on hormone replacement.Â Dr Lie’s job is to provide the missing information.Â She then tells us exactly what to say when asked about hormone replacement.

“how should clinicians approach the conversation with their peri- or postmenopausal patients about the use of bioidentical hormones for their symptoms?”(1)

Understanding a Few Myths

Dr Lie then explains that your doctor should first understand a few myths about bioidentical hormones so these can be clarified in a conversation with you, the patient.Â What are these myths?Â Well, here they are:

Myth (1): “Bioidentical hormone therapy is natural and therefore superior to CHT.” (Note:CHT means Conventional Hormone Therapy, chemically altered synthetic hormones like Merck’s etonorgestrel)

This is not a myth. This is actually a true statement. Hormones made by the human ovary are superior and safer than chemically altered synthetic hormones offered by the drug companies.Â The drug companies must alter the chemical structure of the hormone in order to qualify for patent protection which makes the drug profitable.

Horse Estrogen is NOT Bioidentical Unless You are a Horse

Dr. Lie, in spite of her Oxford and Cambridge pedigree, missed the mark on the meaning of “bioidentical”, a word indicating the chemical structure of the hormone is “identical” to those made by the ovary. Â Dr Lie goes on to make another error in the statement Â “bioidentical products that may be derived from equine or other sources.“.Â Here,Â Dr. Lie is referring to Premarin, estrogen from horses (equine).Â Yes, Premarin is bioidentical if you happen to be a horse.Â Â Horse estrogen (Equilin) is a different chemical structure and is not the human estrogen, estradiol, made in the ovary.Â Premarin is by definition NOT bioidentical, as any high school kid could understand.

Â Myth (2): Compounded bioidentical hormones are better than CHT.

This is actually a true statement, and not a myth.Â There are many reasons why individualized compounded formulation are better than mass produced pre-packaged hormone products.Â The main reason is obvious.Â Compounding allows more versatility and choice by the doctor in making up a specific formulation.Â Three or four hormones can be mixed in proper ratio to make an individualized topical hormone cream.Â This cannot be done with the prepackaged hormone products from the major drug companies like Merck and Pfizer.

Myth (3): Custom compounding individualized to the patient using salivary hormone assessment is superior to CHT because it mimics the patient’s own natural hormone levels.Â Â

Contrary to what Dr Lie says, most patients expect a competent physician to perform testing for either salivary or serum hormone levels.Â Dr Lie says:

“Hormone therapy should be individualized by symptom relief and side-effect profile and not laboratory test results.”

I actually agree with this statement, and we do not routinely use salivary hormone testing.Â Rather hormone dosages are titrated for menopausal symptom relief.Â Â Even so, we routinely include hormone testing on our routine blood testing panels.Â Unlike Dr Lie, I wouldn’t belittle the salivary hormone testing technique, as I have found clinically useful results can be obtained with salivary testing.Â Not only that, there is an extensive body of medical literature on salivary hormone testing in athletes, and in astronauts on the space shuttle (12), etc.Â Left image astronaut courtesy of NASA.

Falling Out of My Chair in Laughter

The next section of Dr Lie’s article is so hilarious, I almost fell out of my chair in laughter.Â In this section, Dr Lie explains how the doctor (that’s me) should use “beneficial persuasion” techniques to convince the patient that bioidentical hormones are “bad” and synthetic chemically altered monster hormones are “good” for you.Â Â These are techniques you might see in a training manual for closing auto sales : 1) vivid depictions, 2) framing, 3) regret, 4) refocusing.Â This might be OK if you are buying a new car.Â It is not OK in your doctor’s office.Â Let me put it very simply. If your doctor is learning how to have a conversation in the office with you about hormone replacement from a Medscape article like this one, then you need a new doctor.Â Left upper image : used car salesman courtesy of Kurt Russell Escape from New york.

Conclusion:

As more and more women and their physicians switch to bioidentical hormones for menopausal symptom relief, the drug industry will become more and more desperate.Â Â We can expect to see more misguided articles like this Medscape comedy of errors, as the public rejects synthetic hormones for the monsters they really are.

Articles with Related interest:

Waking Up from the Synthetic Hormone Nightmare

The Safety of Bio-Identical Hormones

The Importance of Bioidentical Hormones

Bioidentical Estrogen Hormones Could Have Saved 50,000 Lives

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

Links and References

1) http://www.medscape.com/viewarticle/855845

Bioidentical Hormones for Menopause: What Should We Tell Our Patients?

DÃ©sirÃ©e A. Lie, MD, MSEdÂ December 15, 2015Â Served as a speaker for Merck

2) Merck- nuvaring.com

NuvaRing is a small, flexible vaginal ring used to prevent pregnancy. You put it in for 3 weeks, take it out,Â then put a new one in a week later.Â (etonogestrel/ethinyl estradiol vaginal ring)

3) nexplanon.com

NEXPLANON is a small, soft, and flexible birth control implantâitâs just 4 centimeters in length. Your health care provider places it discreetly under the skin on the inside of your upper arm. This means itâs hidden from view. NEXPLANON provides up to 3 years of continuous pregnancy prevention.* That means no more daily, weekly, or monthly dosing routine. (etonogestrel implant)

4) pdf file Merck_Disclosure_Speakers_3Q09-Transparency-Report

Merck & Co., Inc., Disclosure of Payments to U.S. Speakers 2009…paid in 2010

Lie, Desiree Annabel Total 20 events in 2009 for total of $ 39,675.00

5) https://projects.propublica.org/docdollars/doctors/pid/575924

DESIREE A LIEÂ Payments: At a Glance

20Â payments $13,040Â payment total

This doctor received a payment on 15 out of 518 days from Aug. 2013 to Dec. 2014.

6) https://projects.propublica.org/d4d-archive/payments/10880015

Payment DisclosureÂ Lie, Desiree Annabel

$24,275Â Â Â Â paid by Merck Â»

Listed practitioner: Desiree A Lie

Location: ROSSMOOR, Calif.

Payment for: Speaking Information

Reported: Jan. to Dec. 2011

Search for Lie, Desiree Annabel in Prescriber Checkup, our database of prescribing patterns within Medicare’s drug program.

Notable drugs produced by Merck include:Â Â Â Â NuvaRing (contraceptive)

7) pdfÂ Tech_View_6_3_10_Desiree Lie_speaking for Merck

Weekly News | 06.03.10Â Texas Tech

Tech View is published weekly by Communications & Marketing, Texas Tech University Health Sciences

Faculty, residents, students and other healthcare professionals are invited to a presentation on âDelivering Quality Care to Diverse Populations.â Speaker for the presentation isÂ Â Desiree Lie, M.D., director, Division of Faculty Development, University of California, Irvine, Department of Family Medicine.

Dr. Lie received her B.A and M.A. from Cambridge University, and her medical degree from Oxford University, England. She completed residency at Oxford University, received a Masters in Medical Education at the University of Southern California. Dr. Lie is double board-certified in family medicine/general practice in the U.S. and the U.K. She has been published in Academic Medicine, Family Medicine and Medical Education among other distinguished journals. She serves on the editorial board of Medscape. She is also member of the American Academy of Family Physicians and the Society of Teachers of Family Medicine.

The speaker is speaking on behalf of Merck and Co., Inc.

————————————————

8) http://www.medscape.com/public/bios/ed-familymed

Editorial Board â Medscape Family Medicine

Board Members

Desiree A. Lie, MD, MSEdÂ Â Keck School of Medicine, USCÂ Â Los Angeles, California

——————————————————

Speaker Bio:Desiree Lie, MD, MSEd

Desiree Lie, MD, MSEd., is Professor of Medicine at Duke National University of Singapore, Graduate Medical School and at the University of Southern California. She was Professor of Family Medicine at the University of California, Irvine for 22 years, with roles combining practice, educational and research in areas including faculty development, international primary care, integrative medicine, cultural competence, relationship-centered care, the Medical Humanities and health literacy. Dr. Lie attended the Universities of Cambridge and Oxford, England, and completed residency training in Pediatrics and Family Medicine. She is board certified in the UK and US. She is the recipient of multiple teaching awards and grants, an editorial board member and author for Medscape, and is active in federal grant reviews, the STFM, and inter-professional education.

10) Merck Payment Disclosures 3Q10-Transparency-Report-2

11) Writing Group for the Women’s Health Initiative Investigators. “Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial.” Jama 288.3 (2002): 321-333.

12) Putcha, Lakshmi, Ram Nimmagudda, and Chantal Rivera. “Assessment of sleep dynamics in a simulated space station environment.” Isolation: NASA Experiments in Closed-Environment Living- Advanced Human Life Support Enclosed System Final Report 104 (2002): 131-139.Salivary Melatonin NASA AStronauts Sleep Study

13) FDA Approved Patient Labeling NEXPLANON etonogestrel

Disclaimer click here: http://www.drdach.com/wst_page20.html

The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician â patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.

Link to this article

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a âfair useâ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.

The post More Lies about Bioidentical Hormones appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on December 16, 2015 19:26

November 16, 2015

Riboflavin for Hypertension in MTHFR

Riboflavin for Hypertension in MTHFR

Ralph is a 52 year old successful business man who comes into the office because of chronic fatigue and “just not feeling himself”.Â Over the years he was given a diagnosis of ADD, ADHD by his doctor who offered medication which Ralph declined.Â Left image of blood pressure cuff courtesy of AAFP.

Ralph has mild hypertension, and his doctors offered Ralph blood pressure pills for blood pressure of 145 over 95 mm Hg.Â Ralph declined the blood pressure pills, and instead takes supplements such as Magnesium and CoQ-10 and checks his BP at home daily with a home BP monitor.Â Examination reveals that Ralph is in good physical shape.Â He has good muscle tone from regular work outs at the gym, and is otherwise unremarkable.

Homozygous for MTHFR

Laboratory studies show that Ralph is homozygous for the MTHFR C667T mutation, and has elevated homocysteine.Â In addition to the basic protocol listed by Dr Ben Lynch (Basic Protocol for C667T (Click Here), Ralph was given Riboflavin (vitamin B2), a known treatment for hypertension in the MTHFR patient.Â Left Image courtesy of Stop the Thyroid Madness.

Methylation Pathways

How does Riboflavin, vitamin B2, work to reduce blood pressure? Riboflavin is an important co-factor in the methylation pathways, and has been found useful in reducing blood pressure in hypertension associated with homozygous MTHFR C667T .Â Riboflavin (vitamin B2) in the form of FAD acts as a cofactor for MTHFR.(1-2).

Riboflavin More Effective than AntiHypertensive Drugs

In her 2014 article, Dr Helen Mcnulty concludes:

“Thus riboflavin, targeted specifically at this genetically at-risk group, may offer a personalized non-drug approach to managing hypertension.”(2)

In her 2013 article,Â Dr Carol Wilson says:

“In conclusion, these results show that riboflavin supplementation targeted at hypertensive individuals with the MTHFR 677TT genotype can decrease BP more effectively than treatment with current antihypertensive drugs only and indicate the potential for a personalized approach to the management of hypertension in this genetically at-risk group.”(4)

The Homocysteine Connection

Dr Moat says in 2003 (13)

“Riboflavin (vitamin B2) is the precursor for FAD, the cofactor for methylenetetrahydrofolate reductase (MTHFR). MTHFR catalyzes the formation of 5-methyltetrahydrofolate, which acts as a methyl donor for homocysteine remethylation. Individuals with the MTHFR 677C3T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status. It has been proposed that riboflavin may act together with folate to lower plasma tHcy, particularly in individuals with the thermolabile MTHFR T variant.”(13)

Helene McNulty concludes in her 2006 article:

“Although previously overlooked, homocysteine is highly responsive to riboflavin, specifically in individuals with the MTHFR 677 TT genotype.”(14)

Â Riboflavin Deficiency caused by Oral Contraceptives

Studies show that birth control pills may cause riboflavin deficiency, thusÂ aggravating clinical findings in the MTHFR patient.Â (15)Â Left image: Chemical Structure of riboflavin vitamin B2,Â courtesy of wikimedia commons.

Articles with related interest:

Blood Pressure Pills for Hypertension, When to Treat?

Fifty Million Americans have High Blood Pressure

Understanding Online Genetic Testing

Jeffrey Dach MD

7450 Griffin Road Suite 190

Davie, Fl 33314

954-792-4663

Links and references:

1) full pdfÂ Riboflavin Lowers Blood Pressure Strain 2015

Strain, J. J., et al. “Riboflavin Lowers Blood Pressure: A Review of a Novel Gene-nutrient Interaction.” Nutrition and Food Sciences Research 2.2 (2015): 3-6.

full pdf

2) McNulty, Helene, J. J. Strain, and Mary Ward. ”Â Riboflavin lowers blood pressure in hypertensive people with the MTHFR 677TT genotype McNulty 2014 .” Archives of Public Health 72.Suppl 1 (2014): K2.

3) Shi, Zumin, et al. “Riboflavin intake and 5-year blood pressure change in Chinese adults: Interaction with hypertensive medication.” Food & Nutrition Bulletin 35.1 (2014): 33-42.

4) http://hyper.ahajournals.org/content/61/6/1302.full

Wilson, Carol P., et al. “Blood Pressure in Treated Hypertensive Individuals With the MTHFR 677TT Genotype Is Responsive to Intervention With Riboflavin Findings of a Targeted Randomized Trial.” Hypertension 61.6 (2013): 1302-1308.

Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients with premature cardiovascular disease homozygous for the 677CâT polymorphism (TT genotype) in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Whether this effect is confined to patients with high-risk cardiovascular disease is unknown. The aim of this randomized trial, therefore, was to investigate the responsiveness of BP to riboflavin supplementation in hypertensive individuals with the TT genotype but without overt cardiovascular disease. From an available sample of 1427 patients with hypertension, we identified 157 with the MTHFR 677TT genotype, 91 of whom agreed to participate in the trial. Participants were stratified by systolic BP and randomized to receive placebo or riboflavin (1.6 mg/d) for 16 weeks. At baseline, despite being prescribed multiple classes of antihypertensive drugs, >60% of participants with this genotype had failed to reach goal BP (â¤140/90 mm Hg). A significant improvement in the biomarker status of riboflavin was observed in response to intervention (PIn conclusion, these results show that riboflavin supplementation targeted at hypertensive individuals with the MTHFR 677TT genotype can decrease BP more effectively than treatment with current antihypertensive drugs only and indicate the potential for a personalized approach to the management of hypertension in this genetically at-risk group.

5) http://ajcn.nutrition.org/content/95/3/766.short

Wilson, Carol P., et al. “Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.” The American journal of clinical nutrition 95.3 (2012): 766-772.

Optimizing riboflavin status offers a low-cost targeted strategy for managing elevated BP in this genetically at-risk group. These findings, if confirmed in the general population, could have important implications for the prevention of hypertension.

6) Wilson, C. P., et al. “Postgraduate Symposium The MTHFR C677T polymorphism, B-vitamins and blood pressure.” Proceedings of the Nutrition Society 69.01 (2010): 156-165.

7) Horigan, Geraldine, et al. “Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677Câ T polymorphism in MTHFR.” Journal of hypertension 28.3 (2010): 478-486.

8) Ward, Mary, et al. “B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension.” International Journal for Vitamin and Nutrition Research 81.4 (2011): 240-244.

9) McCully, Kilmer S. “Homocysteine, vitamins, and vascular disease prevention.” The American journal of clinical nutrition 86.5 (2007): 1563S-1568S.

10) Lin, et al. “Low Plasma Pyridoxal 5â-phosphate Concentration and MTHFR 677Câ T Genotypes are Associated with Increased Risk of Hypertension.” International journal for vitamin and nutrition research 78.1 (2008): 33-40. Pyridoxal_5_phosphate_MTHFR_677C_Hypertension_Lin_2008

11) Durga, Jane, et al. “Folate and the methylenetetrahydrofolate reductase 677Câ T mutation correlate with cognitive performance.” Neurobiology of aging 27.2 (2006): 334-343.

=========================

12) Hustad, Steinar, et al. “Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.” Clinical Chemistry 46.8 (2000): 1065-1071.

13) Moat, Stuart J., et al. “Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype.” Clinical chemistry 49.2 (2003): 295-302. Riboflavin Homocysteine Folate MTHFR C677T Moat 2003

14) McNulty, Helene, et al. “Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677Câ T polymorphism.” Circulation 113.1 (2006): 74-80.Â Backgroundâ Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677CâT polymorphism have reduced MTHFR enzyme activity resulting from the inappropriate loss of the riboflavin cofactor, but it is unknown whether their typically high homocysteine levels are responsive to improved riboflavin status.

Methods and Resultsâ From a register of 680 healthy adults 18 to 65 years of age of known MTHFR 677CâT genotype, we identified 35 with the homozygous (TT) genotype and age-matched individuals with heterozygous (CT, n=26) or wild-type (CC, n=28) genotypes to participate in an intervention in which participants were randomized by genotype group to receive 1.6 mg/d riboflavin or placebo for a 12-week period. Supplementation increased riboflavin status to the same extent in all genotype groups (8% to 12% response in erythrocyte glutathione reductase activation coefficient; P

Conclusionsâ Although previously overlooked, homocysteine is highly responsive to riboflavin, specifically in individuals with the MTHFR 677 TT genotype. Our findings might explain why this common polymorphism carries an increased risk of coronary heart disease in Europe but not in North America, where riboflavin fortification has existed for >50 years.

15) Newman, Leonard J., et al. “Riboflavin deficiency in women taking oral contraceptive agents.” The American journal of clinical nutrition 31.2 (1978): 247-249. Riboflavin deficiency oral contraceptive Newman 1978 Am J Clin Nutr

Link to this article.

Disclaimer click here: http://www.drdach.com/wst_page20.html

The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician â patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a âfair useâ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.

The post Riboflavin for Hypertension in MTHFR appeared first on Jeffrey Dach MD .

View more on Jeffrey Dach's website »

Like • 0 comments • flag

Published on November 16, 2015 06:13

November 5, 2015

Urgent Protect Vaccine Exemptions in Florida

Urgent

Emergency Call to Action

Protect Vaccine Exemptions in Florida

The following emergency message was posted on This Facebook Page by the National Vaccine Information CenterÂ

——————————————–

Floridians Opposed To SB 646

——————————————–

Update 11/7/15 – The SB 646 Bill was withdrawn prior to introduction.

Good Work Everyone !! Your Voices Were Heard !Â

Remain vigilant because this issue will resurface, like a Hydra with many heads.Â Cut one off, and another appears.

Update 11/6/15

The SB 646 Bill will be discussed in these three Florida Senate committees:Â

Contact the members of each committee with these links and send them your letter opposing SB 646.

SB 646, along with those to contact:

1) Health Policy Committee: https://www.flsenate.gov/Committees/Show/HP

2) Appropriations Subcommittee on Health and Human Services https://www.flsenate.gov/Committees/Show/AHS

3) Committee on Appropriations https://www.flsenate.gov/Committees/Show/

UPDATE 11/5/15

If you havenât contacted your state legislators or the governor yet to OPPOSE SB646, PLEASE DO SO immediately as special session is ending on Friday 11/6! After this, communications will have to be with the district offices.

Read the Entire Bill Here: Florida Senate SB 646 Alan Hays Vaccine Exemptions

SB 646 Sponsor, Senator Hays

Additionally, contact SB 646 Sponsor, Senator Alan Hays, and ask him to withdraw his bill â his contact information is added below.

Alan Hays Florida Senate Web Site.

Left image: Florida Senator Alan Hays 11th DistrictÂ courtesy of wikipedia.

Contact information for D Alan Hays

District Address:

871 South Central Avenue

Umatilla, FL 32784-9290

Phone: (352) 742-6441

Fax: (352) 360-6748

Legislative Address:

320 Senate Office Building

404 South Monroe Street

Tallahassee, FL 32399-1100

Phone: (850) 487-5011

Legislative Assistant:

Nanci Cornwell (Umatilla), Renee Hodges (Clermont)

Email: hays.alan@flsenate.gov

————————————————————————-

This Bill Needs to be KILLED !!Â Â Urgent !!Â

We are requesting you communicate with your state legislators as soon as possible to OPPOSE SB 646 sponsored by Senator D Alan Hays (R) District 11.

This terrible bill has just been filed and it significantly restricts medical and religious vaccine exemptions, it expands and forces participation in a vaccine tracking system, and it requires public posting of vaccination exemption rates for individual schools. It is a major attack on families who donât agree with all doses of all required vaccines. SB 646 needs to be strongly opposed.

The Florida legislature is in attendance in a special session on redistricting until this Friday November 6th so there is a small window of opportunity where legislators are in their offices for you to show strong opposition to this bill to prevent the bill from getting co-sponsors and eventual committee hearings once session starts on January 12th. This bill needs to be killed and we need to come out strong with everyone in Florida contacting their legislators IMMEDIATELY to tell them to oppose SB 646 and do NOT become a co-sponsor.

LEGISLATIVE EDUCATION ACTION NEEDED NOW:

1) CALL, EMAIL, and FAX your Florida State Senator and Representative and ask them to OPPOSE SB 646. Ask them to NOT become a co-sponsor.

If you do not know who your Florida State Senator and Representative are or their contact information, you can find them here at these links

To find your Florida State Senator Click Here.

To find your Florida State Representative Click Here.

Contact the Governor

Contact Governor Rick Scott and ask him to OPPOSE SB 646. Ask for his support to maintain religious and medical exemptions for vaccinations unchanged. And oppose SB 646 which seeks to restrict these exemptions.

You can send email Gov Rick Scott at this LINK.

Office of Governor Rick Scott

State of Florida

The Capitol

400 S. Monroe St.

Tallahassee, FL 32399-0001

(850) 488-7146

3) Contact Senator Alan Hays, primary author of SB 646 by email, phone, fax, or Facebook at https://www.flsenate.gov/senators/s11 and ask him to withdraw SB 646!Â His email is: hays.alan@flsenate.gov

—————————————————————————

Template for Letter :Â This is a template for your letter or emailÂ to your congressman”

[Include your return address so they can see you are in their district, and start by introducing yourself and identifying yourself as a constituent]

I urge you to OPPOSE SB 646 which restricts religious exemptions and medical exemptions for vaccination. This is a bad bill. The bill would mandate government tracking of vaccination records, which are currently confidential medical records protected under the federal HIPPA laws.Â Please do not support or co-sponsor this bill.

[Explain PERSONALLY why it is important to you and your family to have a religious belief or medical vaccine exemption. Add in any relevant personal stories]

I am asking you to oppose this bill, SB 646, because of the following reasons:

1) The bill mandates a new state database system for tracking vaccination records for all children,Â including exemption status.

See Page 2, lines 48-53:

Before the 2017-2018 school year, each child must have a vaccine record on file with vaccination status for required vaccination schedule with the State Health Online Tracking System, or Florida (SHOTS). The Department of Health is to implement this database system.

See page 3, lines 65-66: SB 646 requires Religious Exemption to be recorded in the vaccine tracking system (SHOTS) by Department of Health.

I ask that you oppose this bill because no citizen’s vaccination records or vaccine exemptions should be tracked by their state government.Â Currently, families and their physicians maintain thejr own vaccination records privately.Â These medical records are confidential under federal HIPPA regulations.Â This should not be changed.

2) Bill SB 646 Forces new restrictions on the religious exemption:

Page 2, line 58 â Page 3 line 66: WATCH A VIDEO

Before receiving a religious exemption, SB 646 adds the additional requirement that the parent or guardian must watch a video on vaccination provided by the Department of Health. This proposed video will be made by the Department of Health in collaboration with the Florida Chapter of the American Academy of Pediatrics.Â This is an unusual and unnecessary encroachment of our rights to exercise religious freedom. The video must be made optional, not mandatory.

Government Replaces Physician in the Practice of Medicine

The Bill SB646 replaces the physician’s judgement with a set of rules made by the state legislature, attempting to replace the physician in the practice of medicine.

The new law SB646 restricts the medical exemption:

Page 3, lines 69-80: Restricts the permanent medical exemption to:

âA child who has been diagnosed with T cell or combined T and B cell immunodeficiency, has been diagnosed with any other immunodeficiency for which live virus vaccines are contraindicated, or is undergoing a solid organ or bone marrow transplant and should be permanently exempt from the required immunizationâ or a reason determined by The Department of Health.

Current law allows a personal physician to write a permanent medical exemption:

Instead of the physician making the decision about what criteria to use for a medical exemption, this bill SB646 will limit severely the criteria for medical exemption to a narrow list.Â This is very wrong.Â Many valid medical criteria for vaccine exemption are not listed in Bill SB646.Â It is simply wrong to think that all the criteria can be listed, as each case is individual. Â The state legislature should not attempt to practice medicine,Â nor try to replacement the physician’s judgment with a set of rules in Bill SB 545.

The new law SB646 requires the exemption rates for schools be disclosed online.

Page 5, lines 124-130: Requires the Health Department and all public and private schools to post the schoolâs vaccine exemption rates on their websites.Â This is an undue waste of school time and resources, and a waste of taxpayers money.Â Vaccination exemption records are confidential medical information protected by federal HIPPA regulations and therefore not to be publicly disclosed.

Sincerely,

(Your name, address, phone number, email etc.)

Links and References

Link to Florida Senate Bill SB 646: Childhood Immunizations – GENERAL BILL by Alan Hays

Childhood Immunizations; Requiring certain immunization records to be on file with the State Health Online Tracking System by a specified date; revising exemptions to the school-entry health examination and immunization requirements; requiring the Department of Health, in collaboration with the Florida Chapter of the American Academy of Pediatrics, to prepare an informational video on immunizations for a parent or guardian to view before requesting an exemption; requiring the department to publish immunization and exemption rates for each public and private school on its website by a specified date, etc.

Effective Date: 7/1/2016

Last Action: 11/4/2015 Senate – Referred to Health Policy; Appropriations Subcommittee on Health and Human Services; Appropriations

Location: In committee/council (HP)

—————————-

Representative D Alan Hays Web Site

——————————–

Find Your Florida State Representative Here.