Jeffrey Dach's Blog, page 19
May 16, 2017
ADHD Attention Deficit Syndrome Part Two
[image error] ADHD Attention Deficit HyperActivity Syndrome Part Two by Jeffrey Dach
Susan is a 13 year old 8th grader with behavior problems. Her parents have disciplined her frequently by confiscating her cell phone, restricting her activities, etc. However, none of this seems to help. Susan is frequently inattentive and fidgety in class. Out of desperation, the parents took Susan to a psychiatrist who started her on Prozac after an extreme behavioral outburst. In my office, on examination, Susan’s pupils are dilated and reflexes hyperactive, typical adverse effects from SSRI drugs. Susan’s labs show a low serum cholesterol and low ferritin levels. Above left image courtesy of Curious Mind Magazine “Renouned Psychiatrist Says ADHD is Largely a Fraud.”
[image error]I explained to Susan’s parents that SSRi drugs are not advisable, as they may lead to “mania and psychosis” with diagnosis of “bipolar syndrome “.(1) This is a devastating outcome because Susan would then be placed on atypical antipsychotic medication which would destroy any possibility of having a normal life.(1) However, the parents insist the SSRI drugs have calmed Susan down, and her behavior has improved.
The Problem Child- ADD, ADHD
[image error]This brings us to the “problem child” whose parents look to the medical system for help with a “behavior problem” and are handed one or more psycho-active drugs for their child. Amphetamines such as Ritalin, Adderal and Vyvanse are commonly handed out for the inattentive, or hyperactive child who is given the “rubber stamp” diagnosis of ADD, ADHD, a manufactured diagnosis used to create massive profits in the criminal marketing of amphetamines to children. In reality, the behavioral outbursts are a “red flag” for an underlying biologic, metabolic or nutritional disorder.Left Image: Psychiatric Testing for ADD ADHD is an unreliable series of questions, Swami with crystal ball courtesy of James Greenblatt MD.
In part one of this series, we examined the criminal activities of the drug industry, marketing amphetamines to children and young adults under the guise of medication for a manufactured disease called ADD, ADHD.
[image error]James Greenblatt MD Integrative Psychiatrist
In part two, this article, we present to you the work of James Greenblatt MD, a child psychiatrist in the Boston area with an integrative approach to the ADD, ADHD child with behavior problems.
Dr Greeblatt spoke at the 2017 Toronto Orthomolecular Medicine Conference, and presented his material on the treatment of ADHD with a nutritional supplement called OPC- Pycnogenol.
Dr Greenblatt believes “biological and nutritional factors that often play a role.” in the ADHD child with behavior problems. He draws attention to “food additives and nutritional deficiencies”.
This is what Dr Greenblatt says about ADHD (8)
“Attention Deficit Hyperactivity Disorder (ADHD) is the most recent name for a complex neurobiological disorder that occurs in children, adolescents, and adults. Symptoms include difficulty with attention, concentration, memory, organization, and for some, impulsivity, hyperactivity, aggressiveness, and relationship problems. The scientific research has clearly documented that ADHD is a brain-based disorder.
There are many biological abnormalities in individuals suffering with ADHD. It is a medical disorder that affects behavior; it is not a “discipline problem.” Many untreated children with ADHD develop oppositional behavior and become a “discipline problem.” For some individuals, the right choice of medication can be an invaluable asset in treatment. Unfortunately, medications do not treat the biochemical or neurological imbalances underlying ADHD and many medications have side effects. When individuals are off medication the symptoms of ADHD return and frequently are worse than before medication.”(8)
Pycnogenol and the EEG in ADHD
Dr Greenblatt presented his case material on EEG findings in children before and after 3 months treatment with Pycnogenol, an antioxidant polyphenol supplement. (2)(9-11) Dr Greenblatt’s many presentations on this topic can be seen on You-Tube.(3) and in his book available on Amazon.(4)
EEG Finding in ADD, ADHD
On the EEG (electroencehalogram), ADHD kids have increased theta waves associated with day dreaming and inattention. At the same time they have reduced beta waves which are associated with focusing and paying attention. In Dr Greenblatt’s experience these EEG findings normalize after 3 months of Pycnogenol supplementation. In addition, teachers and parents report improved behavior in the child.
A number of other interventions have been described by other authors. Dr James Greenblatt reports a case of a child with absent lithium on a hair analysis who responded to low dose lithium orotate, a nutritional supplement. Others have found useful iron supplementation for low ferritin useful.(5) As mentioned in part one, diet modifications such as avoiding food colorings, and sugar foods can often be helpful. Other causes to look for: Lead toxicity, Food Allergies, Vitamin deficiencies, organo-phosphate exposure, BPA depletes zinc, celiac disease, malabsorption, wheat gluten intolerance, sensitivity to red dyes
Neuropeptides in Food
Dairy – Casein – Casomorphin – morphine analog
Wheat- Gliadin- gliadorphin- morphine analog – found in OCD
Urine testing available for casomorphin and gliadomorphin from Great Plains.
HPHPA Clostridia Metabolite – elevation associated with psychiatric symptoms… Urine Testing (Organic Acids) available at Great Plains William Shaw.
Oxidative Damage in ADD ADHD Children
What if I told you that breathing oxygen is harmful to our health? You would say that is crazy because we breath oxygen 20 times a minute. The reality is that the by-products of energy production (oxidative phosphorylation) are harmful. We make energy by oxidation of carbon in the electron transport chain in our mitochondria. The byproducts of this reaction are called reactive oxygen species (ROS) which can damage our cell membranes and our DNA. We are protected by our anti-oxidant system which quenches these free radicals before they damage our cell structures. What if our anti-oxidant system is defective ? Research shows that this is the case for ADD, ADHD kids who have increased markers of oxidative damage.(10) In a research study, the anti-oxidant pycnogenol reduces these markers of oxidative damage in ADD ADHD kids. (10) Perhaps this is the mechanism by which anti-oxidant polyphenols exert health benefits in these kids with behavioral problems.
Testing Protocols
Dr Greenblatt finds these forms of testing useful:
Food Allergy Testing (IgG)
Organic Acids (Great Plains, William Shaw)
Hair Analysis (may show mineral deficiency)
Routine lab blood work (may show low ferritin, lead,gluten sensitivity)
Electroencephalogram (abnormal ratio of theta to beta waves)
[image error]Chinese Skullcap for ADD ADHD
Chinese Skullcap is a botanical flowering plant which is antiviral, anticancer, anti-inflammatory. It is beneficial for the brain and nervous system. In a mouse animal model of ADHD, chinese skullcap showed remarkable benefits. (6-7) Left Image: Chinese Skullcap flowering plant.
Buy Chinese Skullcap (Scutellaria baicalensis) on Amazon
Buy Pycnogenol on Amazon
Buy Lithium Orotate on Amazon
Articles with Related Interest:
Attention Deficit Disorder Exposed as Drug Marketing Ploy
Lithium Orotate the great Protector
More on Anti-Inflammatory Effects of Chinese Skullcap
Reference Links
Mania and Psychosis from SSRI drugs
1) Preda, Adrian, Rebecca W. MacLean, and Malcolm B. Bowers. “Antidepressant-associated mania and psychosis resulting in psychiatric admissions.” The Journal of clinical psychiatry 62.1 (2001): 30-33.
Prozac is the only SSRI drug approved for use in adolescents and children, and carries a black box warning. None of the others are approved for use in children. The long term effect of this drug on the developing brain is largely unknown, which means that administration of such a drug to an adolescent or child represents an uncontrolled medical experiment, the outcome of which is largely unknown.
Mania and psychosis are known adverse effect of SSRI antidepressant drugs resulting in 8% of admissions to a general hospital psychiatric ward over 14 month study period. “Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis”.
2) Video: “Integrative Therapies for the Treatment of ADHD” by Dr. James Greenblatt from The Great Plains Laboratory
According to the CDC, Attention deficit-hyperactivity disorder (ADHD) currently affects approximately 14% of American children. This webinar will provide the information to understand, treat, and prevent ADHD by addressing the biological and nutritional factors that often play a role in causing and sustaining this disorder. This webinar will draw connections on how food additives and nutritional deficiencies can exacerbate ADHD symptoms. With increasing concerns of medication side effects, alternative treatment options to treat ADHD will also be reviewed.
Adhd and the EEG
theta slow day dreaming – inattention
beta – paying attention-focus
Pycnogenol studies in ADHD
3) Videos on You Tube ADHD James Greenblatt
4) BOOK on Amazon Finally Focused: The Breakthrough Natural Treatment Plan for ADHD That Restores Attention, Minimizes Hyperactivity, and Helps Eliminate Drug Side Effects Paperback – May 9, 2017 by James Greenblatt M.D. (Author), Bill Gottlieb CHC (Author)
5) dela Peña, June Bryan, et al. “Updates on the Use of Natural Treatments for Attention-Deficit Hyperactivity Disorder (ADHD).” ADHD-New Directions in Diagnosis and Treatment. InTech, 2015. Natural Treatments for Attention Deficit Hyperactivity Disorder ADHD dela Pena June Bryan InTech 2015
Oroxylin A – Chinese Skullcap -Baical
6) Yoon, Seo Young, et al. “Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro.” Archives of pharmacal research 36.1 (2013): 134-140.
oroxylin A improves ADHD-like behaviors in SHR via enhancement of DA neurotransmission and not modulation of GABA pathway as previously reported.
7) dela Peña, Ike C., et al. “5, 7-Dihydroxy-6-methoxy-4′-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously hypertensive rats.” European journal of pharmacology 715.1 (2013): 337-344.
Pycnogenol -OPC for ADHD
8) Assessment, E. E. G. “Female, 47 years of age Case history: First consultation.” James Greenblatt MD
Attention Deficit Hyperactivity Disorder (ADHD) is the most recent name for a complex neurobiological disorder that occurs in children, adolescents, and adults. Symptoms include difficulty with attention, concentration, memory, organization, and for some, impulsivity, hyperactivity, aggressiveness, and relationship problems. The scientific research has clearly documented that ADHD is a brain-based disorder.
There are many biological abnormalities in individuals suffering with ADHD. It is a medical disorder that affects behavior; it is not a “discipline problem.” Many untreated children with ADHD develop oppositional behavior and become a “discipline problem.” For some individuals, the right choice of medication can be an invaluable asset in treatment. Unfortunately, medications do not treat the biochemical or neurological imbalances underlying ADHD and many medications have side effects. When individuals are off medication the symptoms of ADHD return and frequently are worse than before medication.
9) Oligomeric Proanthocyanidins for the Treatment of ADHD
by James Greenblatt | May 1, 2017 | Integration, Magazine
10) Chovanová, Zuzana, et al. “Effect of polyphenolic extract, Pycnogenol®, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder.” Free radical research 40.9 (2006): 1003-1010. Pycnogenol in attention deficit hyperactivity disorder Chovanová Zuzana Free radical research 2006
11) Trebatická, Jana, et al. “Treatment of ADHD with French maritime pine bark extract, Pycnogenol®.” European child & adolescent psychiatry 15.6 (2006): 329-335. Treatment of ADHD with Pycnogenol Trebaticka Jana European child adolescent psychiatry 2006
EEG
12) Saad, Jacqueline F., et al. “Is the theta/beta EEG marker for ADHD inherently flawed?.” Journal of attention disorders (2015): 1087054715578270.
12) Poil, S-S., et al. “Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD).” Clinical Neurophysiology 125.8 (2014): 1626-1638.
Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD). Poil SS1, Bollmann S2, Ghisleni C3, O’Gorman RL4, Klaver P5, Ball J6, Eich-Höchli D7, Brandeis D8, Michels L9.
Objective biomarkers for attention-deficit/hyperactivity disorder (ADHD) could improve diagnostics or treatment monitoring of this psychiatric disorder. The resting electroencephalogram (EEG) provides non-invasive spectral markers of brain function and development. Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification.
METHODS: This study provides an integrated analysis of ADHD and developmental effects in children and adults using regression analysis and support vector machine classification of spectral resting (eyes-closed) EEG biomarkers in order to clarify their diagnostic value.
RESULTS: ADHD effects on EEG strongly depend on age and frequency. We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups. However, for ADHD adults we found a slowing in alpha frequency combined with a higher power in alpha-1 (8-10Hz) and beta (13-30Hz). Support vector machine classification of ADHD adults versus controls yielded a notable cross validated sensitivity of 67% and specificity of 83% using power and central frequency from all frequency bands. ADHD children were not classified convincingly with these markers.
CONCLUSIONS: Resting state electrophysiology is altered in ADHD, and these electrophysiological impairments persist into adulthood.
SIGNIFICANCE: Spectral biomarkers may have both diagnostic and prognostic value.
13) Mazaheri, Ali, et al. “Differential Oscillatory EEG between Attention Deficit Hyperactivity Disorder Subtypes and Typically Developing Adolescents.” Biological psychiatry 76.5 (2014): 422.
14) Verlaet, Annelies AJ, et al. “Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD): study protocol for a randomised controlled trial.” Trials 18.1 (2017): 145.
15) New York TImes Suicide from Aphetamines for ADHD
Disclaimer click here: www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Link to this article:http://wp.me/p3gFbV-52o
Copyright (c) 2017 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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May 5, 2017
Error in Thyroid Case Report Toxic Nodular Goiter
[image error]AACE 2017 Annual Meeting – Case Report in Error
At the AACE 2017 Annual Meeting, Sarah Fishman, MD, PhD, of Lenox Hill Hospital, in New York, NY, presented a case report of a patient who developed thyroid disease after taking 2000 mcg per day of iodine in the form of a nutritional supplement containing iodine. Left image iodine tablets used in event of nuclear power plant accident emergency .
This case is in error because the patient had pre-existing toxic nodular goiter with autonomous nodule. In these rare cases, Iodine is contraindicated because iodine will cause thyrotoxicosis. The iodine did not cause the underlying thyroid disease of toxic nodular goiter. This case report is a gross error.
[image error]The reality is that iodine intake of 2,000 mcg per day is common in many Asian diets, which are high in Iodine, and these populations are healthy with no adverse effects. This error was made because the authors are so focused on vilifying iodine, they missed the correct diagnosis of toxic nodular goiter with autonomous nodule. Iodine is so safe, in 1924, the government mandated a program of salt iodination for the entire population resulting in considerable health benefits for the population. The government also mandates 65 mg of iodine for the population surrounding a nuclear power plant accident.
[image error] Left image: Toxic nodular Goiter on radionuclide thyroid scan. Note multiple nodules. Iodine is contra-indicated as this will cause thyroid storm and thyro-toxicosis.
In general, Iodine serves to suppress thyroid function, and does not cause hyperthyroidism in the general population. In agreement is Dr. Dayan in his 1996 article on Chronic Autoimmune Thyroiditis in the New England Journal (3):
“However, iodine reduces thyroid secretion in both subjects with thyroid autoantibodies and those without thyroid autoantibodies, suggesting that it acts by inhibiting the biosynthesis and release of thyroid hormone rather than by augmenting thyroid autoimmunity. “(3)
Conclusion: This Case Report is deceptive and misleading and misses the patient’s correct diagnosis. Iodine did not cause the patient’s underlying thyroid disease of toxic nodular goiter with autonomous nodule. Yes, Iodine did cause the thyrotoxicosis episode which resolved upon withdrawing the iodine. Iodine is contra-indicated in these rare cases, and generally safe for the remainder of the population.
Articles with Related Interest:
Iodine Induced Hyperthyroidism
Making Smarter children with Maternal Iodine Supplements
Jeffrey Dach MD
7450 Griffin Road, Suite 180
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www.jeffreydachmd.com
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Links and references
1) May 04, 2017 Case: Dietary Supplement Use Leads to Thyroid Disease
3) Autoimmune_Thyroiditis_Dayan_NEJM_1996 (Full pdf)
http://www.ncbi.nlm.nih.gov/pubmed/8649497
N Engl J Med. 1996 Jul 11;335(2):99-107.
Chronic autoimmune thyroiditis. Dayan CM, Daniels GH.
“However, iodine reduces thyroid secretion in both subjects with thyroid autoantibodies and those without thyroid autoantibodies, suggesting that it acts by inhibiting the biosynthesis and release of thyroid hormone rather than by augmenting thyroid autoimmunity. “
Disclaimer click here: www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Link to this article:http://wp.me/p3gFbV-51V
Copyright (c) 2017 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
The post Error in Thyroid Case Report Toxic Nodular Goiter appeared first on Jeffrey Dach MD.
March 30, 2017
Join Me at the 2017 Orthomolecular Medicine Meeting
[image error] Join Me at the 2017 Orthomolecular Medicine Meeting April 28-30, 2017, Toronto, Canada
I am proud to be joining Dr Phyllis Bronson for the Bio-identical Hormone Session. My talk is entitled: Errors in Modern Thyroid Endocrinology.
Click Here for: Meeting Schedule and Register for Meeting
Free Download of my Power Point Slides of my talk at the Meeting.
Click Here : Bioidentical_OrthoMol_Toronto_2017_JDach_ZZ6_NarrOff
Location of Meeting: OMNI King Edward Hotel, Toronto, ON
Additional Information and Online Registration – https://www.isom.ca/omt/
Conferene Brochure Click here:
Orthomolecular Medicine Toronto 2017 OMT Conference Brochure [PDF]
Presentations and Speakers
Session One – Friday, April 28 // 9:00AM – 12:30PM
In-Hospital Vitamin C Deficiency and High-Dose Vitamin C Therapy- John Hoffer, MD, PhD
Dr Rogers Prize Lecture – Optimal Nutrition and Chronic Disease Prevention: A Clinical Perspe-ctive on Laboratory Diagnostics Aileen Burford-Mason, PhD
Towards a Unified Theory of Chronic Illness – Ron Hunninghake, MD
Session Two Friday, April 28 // 2:00 PM – 5:30 PM
Plant Based Reversal of Heart Disease Joel Kahn, MD
Evidence Based Integrative Cardiology Jack Wolfson, DO
Give the Body What it Needs and Take Away What it Doesn’t Heather Wolfson, DC
Session Three Saturday, April 29 // 9:00 AM – 12:30PM
Childhood Absence Epilepsy: Putative Complementary Diet and Orthomolecular Treatment Options Jonathan Prousky, ND, MSc
Bioidentical Hormones: The Foundational Molecules of Women’s Emotions- Phyllis Bronson, PhD
The Clinical Approach to Bioidentical Hormone Replacement: Errors in Modern Thyroid Endocrinology Jeffrey Dach, MD
Session Four Saturday, April 29 // 2:00 PM – 5:30 PM
Orthomolecular Psychiatry in Japan Osamu Mizukami , MD
Phytochemicals in the Treatment of ADHD James Greenblatt, MD
Annual Abram Hoffer Memorial Lecture
Distinct Characteristics of Hematological Parameters in Psychiatric Disorders
Toru Mizoguchi , MD
ISOM Annual Meeting Sunday, April 30 // 8:30 AM – 10:00 AM
Annual Updates from Representatives of Societies in Africa, Asia, Europe, North and South America
Orthomolecular Medicine Today Forum Sunday, April 30 // 10:30 AM -12:30 PM
Open Forum Discussion Lead by 2017 Conference Speakers and Orthomolecular Clinicians
IV Vitamin C Academy Sunday, April 30 1:30 PM – 5:00 PM
The post Join Me at the 2017 Orthomolecular Medicine Meeting appeared first on Jeffrey Dach MD.
March 26, 2017
Statin Drugs and Botanicals Anti-Inflammatory Effects
Statin Drugs Anti-Inflammatory Effects Reduce Mortality after Cardiac Surgery.
Would Botanicals Be Better? Take Your Statins !
For those of us with heart disease requiring cardiac bypass surgery (CABG), The New York Times advises we all take statins drugs, since studies show 50% reduction in mortality for those taking statin drugs after CABG.(1) I was somewhat amazed and perplexed by this, since I had already written a previous article ridiculing the idea that statin drugs prevent surgical complications. Now I thought I might have to eat my hat and issue a retraction. Header image: Cardiac Bypass Operation courtesy of wikimedia commons.
Pleiotropic Effects
The two studies on this statin drug benefit for cardiac bypass by Curtis and Barakat refer to the anti-inflammatory “pleiotropic effects” of statin drugs. Cardiac bypass is associated with massive release of proinflammatory cytokines and intense systemic inflammatory response.(2,3) Statin drugs can help with all this inflammation by down regulating Nuclear Factor Kappa Beta (NF-κ B), the master controller of the inflammatory response.(2,3) So, yes, there is a potential benefit for Statins as anti-inflammatory agents. Statin drugs block the inflammatory cytokine release in the post operative patient, thus reducing mortality from the procedure.
Lipophilic statin drugs such as atorvastatin, simvastatin seem to work best. Surprising, the authors comment that there was no proven reduction in myocardial infarction post cardiac bypass with statin drug use. This was a disappointment. The reduction in mortality and episodes of atrial fibrillation was thought to be due to reduction in systemic inflammatory response.(2,3)
Since it appears that the benefit of statin drugs in this population is not as a cholesterol reducing agent. The benefits are due to anti-inflammotry properties of statins. If so, then one might consider other anti-inflammatory interventions which down regulate NFkB. Here is a list of widely available Botanicals which exert anti-inflammatory effect by down regulating Nuclear Factor Kappa Beta (NF-κ B) .
Curcumin
Ginger (Zingiber officinale)
Holy Basil (Ocimum )
polygonum cuspidatum
Berberine (Coptis Chineensis and Barberry, Oregon grape)
Oregano
Chinese Skullcap (Baicalein Oroxylin A)
Rosemary
Although these can be purchased separately on Amazon or your local vitamin store, New Chapter has created a combination product which includes them all in product called Zyflamend, containing a shopping bag of herbal extracts. Some are super critical extracts, revealing the higher quality of the product.[image error]
Blocking Inflammation by
Down Regulating Nuclear Factor Kappa Beta
Inflammation triggered by Nuclear Factor Kappa Beta (NF-κ B) is up-regulated in many other diseases such as osteo-arthritis, viral infections and cancer, so you might predict that many of the individual components of Zyflamend are useful for them all. You would be quite correct.
Left Image Chinese Skullcap Courtesy of wikimedia commons.
Osteoarthritis
Zyflamend, or the individual components would be useful for reducing joint inflammation associated with cartilage loss in osteoarthritis or rheumatoid arthritis. For example, Curcumin alone has been proposed as a new paradigm in the management of osteoarthritis. (56) Many of the testimonials on the Amazon Zyflamend product page are from people attesting to good results for arthritis relief.(56)
Anti-Cancer Studies – Prostate Cancer
Most of the anti-cancer effects of Zyflamend have been prostate cancer models, with considerable benefits(4-8) Thus this product, or something similar, would be an excellent choice for a “Watch and Wait” nutritional program for elevated PSA. A few other items such as Pterostilbene and Serrapeptidase would be included. We have followed a number of men with this scenarios and all PSA’s have remained stable or decreased over time. (see my article on Pterostilbene for prostate cancer prevention)
Zyflamend also showed cancer suppression in a DMBA induced oral cancer model in hamsters.(10) An in-vitro cell culture study showed Zylfamend suppressed melanoma cells.(11)
Many Other Anti-Cancer Studies
Studies on Curcumin, Berberine, Ginger, Holy Basil, and Chinese Skullcap have all shown anti-cancer activity.(12-54) Berberine and curcumin are actually synergistic in anti-cancer activity against breast cancer cells.(24)
Benefits for Cardiovascular Disease
If cardiovascular disease and atherosclerosis is caused by inflammation, as many now believe, this would explain many of the benefits of statin drugs which are, after all, anti-inflammatory drugs. Statins were originally developed as an anti-cholesterol drug, it was only much later that the anti-inflammatory effects were discovered.
My previous article reported that statin drugs are a failure for reducing calcium score, and may actually accelerate calcium score progression. The cardiovascular benefit of Aged Garlic is far superior to statin drugs for reducing calcium score.
Perhaps anti-inflammatory herbals such as Zyflamend would be more effective than Statin Drugs with fewer adverse side effects for reducing calcium score if combined with Aged Garlic and Vitamin K2. We await these studies.
In the mean-time, studies on the Zyflamend individual components such as Berberine have shown remarkable benefits in prevention and treatment of cardiovascular disease.(25-29)
Curcumin has been shown effective in retarding atherosclerosis in an Apo E mouse model of atherosclerosis.(55)
Chinese Skullcap (bacailein) has remarkable benefits for preventing cardiovascular disease by “decreasing the oxidation of LDL and suppressing inflammatory responses in macrophages”.(31)(33-35)
Anti-Viral Herbal Agents
As mentioned in my previous article on Anti-Viral Herbal Agents, Chinese Skullcap has both anti-viral and anti-inflammatory properties. Dr Stephen Buhner mentions in his book the more virulent and deadly viral illnesses such as the 1918 influenza epidemic are so dangerous because of the viral induced “cytokine storm”, a severe inflammatory response which overwhelms and kills the patient. Botanicals like Chinese Skullcap are not only potent anti-viral agents, they also turn off this cytokine storm, thereby exerting powerful anti-inflammatory effects.(31)
Conclusion
One might wonder about the outcome of an NIH funded study comparing the anti-inflammatory effects of statin drugs to a botanical product like Zyflamend in such diverse conditions such as arthritis, atherosclerosis, and cancer, as well as mortality after bypass graft surgery. Perhaps botanicals would have superior anti-inflammatory effects, compared to Statin Drugs, without the adverse effects of CoQ-10 depletion, myalgia, neuropathy, diabetes etc.
However, considering the current state of NIH research funding, this study would never happen. It the mean time, those of us who don’t have the luxury of time will incorporate the anti-inflammatory botanicals into our routines whenever possible.
Jeffrey Dach MD
Articles with related Interest:
Statins Reduce Perioperative Mortality Surely Your Joking
Berberine Antidote for an Epidemic
Aged Garlic Benefits for Reducing Calcium Score
LPS Theory of Coronary Artery Disease
References
1) Having Heart Surgery? Don’t Stop Your Statins
By NICHOLAS BAKALAR MARCH 16, 2017 New York Times
2) Curtis, Michael, et al. “Effect of Dose and Timing of Preoperative Statins on Mortality After Coronary Artery Bypass Surgery.” The Annals of Thoracic Surgery (2017).
Thirty-day all-cause mortality was significantly lower for patients taking a statin 24 hours or less preoperatively (1.7%) compared with 24 to 72 hours (2.9%), more than 72 hours, or no dose (3.8%). Multivariate analysis of a propensity-matched cohort showed taking statins 24 hours or less preoperatively was associated with reduced 30-day all-cause mortality (odds ratio 0.52, 95% confidence interval: 0.28 to 0.98, p = 0.04) versus more than 24 hours or no dose. For preoperative statin dose, 30-day all-cause mortality was significantly lower when taking 20 mg or less(1.8%) or more than 20 mg atorvastatin or equivalent (2.1%) than when taking none (3.8%). In multivariate analysis of the propensity-matched cohort, more than 20 mg preoperative dose was associated with a 68% reduction of 30-day all-cause mortality (odds ratio 0.32, 95% confidence interval: 0.13 to 0.82, p = 0.02) compared with no preoperative statin. However, a 20 mg or less preoperative dose showed no mortality reduction.
statin benefits may extend beyond lipid control [4, 16]. These lipid-independent mechanisms, called pleiotropic effects, involve antiinflammatory, antioxidant, antithrombotic, and vasodilatory pathways. Specifically, in addition to being a precursor for cholesterol, HMG-CoA is a precursor for other nonsteroidal isoprenoid products (eg, farnesyl pyrophosphate and geranylgeranyl pyrophosphate) [17]. These molecules are essential for the posttranslational modification of intracellular guanosine triphosphate-binding proteins, such as Rho, Ras, and Rac1 GTPases [17, 18]. Rho activates nuclear factor-κB, which signals initiation of several inflammatory responses and the reduction of endothelial nitric oxide synthase [19, 20].
3) Barakat, Amr F., et al. “Perioperative statin therapy for patients undergoing coronary artery bypass grafting.” The Annals of thoracic surgery 101.2 (2016): 818-825.
Coronary artery bypass grafting is associated with an intense systemic inflammatory response, which is linked to postoperative complications. Beyond lipid lowering, statins exert a constellation of beneficial actions, including an antiinflammatory role, known as pleiotropic effects. There is increasing evidence that perioperative statin therapy improves outcomes in patients undergoing coronary artery bypass grafting. Statins are underused in the coronary artery bypass grafting population, because perioperative discontinuation remains a common practice.
Zyflamend
4) Yang, Peiying, et al. “Zyflamend®-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.” Cancer biology & therapy 6.2 (2007): 228-236.
5) Capodice, Jillian L., et al. “Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial.” Journal of the Society for Integrative Oncology 7.2 (2009): 43.
6) Bemis, Debra L., et al. “Zyflamend®, a Unique Herbal Preparation With Nonselective OX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression.” Nutrition and cancer 52.2 (2005): 202-212.
7) Huang, E-Chu, Michael F. McEntee, and Jay Whelan. “Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer.” Nutrition and cancer 64.5 (2012): 749-760.
8) Rafailov, Samuil, et al. “The role of Zyflamend, an herbal anti-inflammatory, as a potential chemopreventive agent against prostate cancer: a case report.” Integrative cancer therapies 6.1 (2007): 74-76.
9) Sandur, Santosh K., et al. “Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-κ B Activation and NF-κ B–Regulated Gene Products.” Nutrition and cancer 57.1 (2007): 78-87.
10) Yang, Peiying, et al. “Zyflamend® reduces LTB4 formation and prevents oral carcinogenesis in a 7, 12-dimethylbenz [α] anthracene (DMBA)-induced hamster cheek pouch model.” Carcinogenesis 29.11 (2008): 2182-2189.
11) Ekmekcioglu, Suhendan, et al. “Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells.” Nutrition and cancer 63.6 (2011): 940-949.
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Curcumin
12) Fadus, Matthew C., et al. “Curcumin: An age-old anti-inflammatory and anti-neoplastic agent.” Journal of Traditional and Complementary Medicine (2016). CurcuminRich Double Strength Theracurmin
13) Wang, Ke, et al. “Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.” Anti-cancer drugs 26.1 (2015): 15-24.
14) Dasiram, Jade Dhananjay, et al. “Curcumin inhibits growth potential by G1 cell cycle arrest and induces apoptosis in p53-mutated COLO 320DM human colon adenocarcinoma cells.” Biomedicine & Pharmacotherapy 86 (2017): 373-380.
15) Ravindran, Jayaraj, Sahdeo Prasad, and Bharat B. Aggarwal. “Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?.” The AAPS journal 11.3 (2009): 495-510.
16)
Shanmugam, Muthu K., et al. “The multifaceted role of curcumin in cancer prevention and treatment.” Molecules 20.2 (2015): 2728-2769.
17) free pdf
Zhang, Jianbin, et al. “Curcumin targets the TFEB-lysosome pathway for induction of autophagy.” Oncotarget 7.46 (2016): 75659-75671.
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Ginger
free pdf
18) Ansari, Jamal Akhtar, et al. “Anticancer and Antioxidant activity of Zingiber officinale Roscoe rhizome.” (2016).
19) Food Chem Toxicol. 2010 Oct;48(10):2872-80. doi: 10.1016/j.fct.2010.07.020. Epub 2010 Jul 18. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells.
Choudhury D1, Das A, Bhattacharya A, Chakrabarti G.
Ginger has a long history of use as traditional medicine for varied human disease. Our present study has shown that the aqueous extract of ginger (GAE) interacts directly with cellular microtubules and disrupts its structure and induces apoptosis of cancer cells as well. The IC(50) values of GAE, as determined from cell viability experiment on human non-small lung epithelium cancer (A549) cells and human cervical epithelial carcinoma (HeLa), were 239.4+7.4 and 253.4+8.9 μg/ml, respectively. It has been found that the apoptosis of A549 cells by GAE is mediated by up regulation of tumor suppressor gene p53 and alteration of the normal Bax/Bcl-2 ratio followed by down regulation of cellular pro-caspase3. The morphological change of cells upon GAE treatment has also been demonstrated. Both the structural and functional properties of tubulin and microtubule were lost, as confirmed by both ex vivo and invitro experiments. The major component of GAE is poly-phenols (around 2.5%), which consist of ∼ 80% flavones and flavonols. Poly-phenolic compounds are well known to have anti-mitotic properties, and may be further screened for the development of a potential anti-cancer agent.
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holy Basil
20) Manaharan, Thamilvaani, et al. “Purified essential oil from Ocimum sanctum Linn. triggers the apoptotic mechanism in human breast cancer cells.” Pharmacognosy magazine 12.Suppl 3 (2016): S327.
21) Manaharan, Thamilvaani, et al. “Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves.” The Scientific World Journal 2014 (2014).
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Green tea
22) Green Tea for prevention of Skin cancer
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polygonum cuspidatum
free pdf
23) Peng, W., et al. “Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb. et Zucc.: a review.” Journal of ethnopharmacology 148.3 (2013): 729-745.
Polygonum cuspidatum has a wide spectrum of pharmacological effects including lipid regulating effect, anti-shock effect, anti-inflammatory effect, antioxidant effect, anticancer effect, hepato-protective effect, antiviral effect, and antibacterial and antifungal effects
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Coptis Chineensis and Barberry (Berberine)
24) Wang, Kai, et al. “Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.” Scientific reports 6 (2016).
24) Sun, Yiyi, et al. “A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs.” Anti-cancer drugs 20.9 (2009): 757-769.
Berberine in Cardiovascular Disease
25) Zhang, Ming, et al. “Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease.” Current Pharmacology Reports 2.6 (2016): 281-292. and
26) Jeong, Hyun Woo, et al. “Berberine suppresses proinflammatory responses through AMPK activation in macrophages.” American Journal of Physiology-Endocrinology and Metabolism 296.4 (2009)
27) https://www.ncbi.nlm.nih.gov/pubmed/11607041
Lau, Chi‐Wai, et al. “Cardiovascular actions of berberine.” Cardiovascular Drug Reviews 19.3 (2001): 234-244.
28) http://link.springer.com/article/10.1007/s40495-016-0070-1
December 2016, Volume 2, Issue 6, pp 281–292
Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease. Ming Zhang Linjing Feng Junnan LiLi Chen
29) https://nutritionreview.org/2013/04/drugfree-alternatives-arrhythmia/
Researchers studied the effects of berberine on individuals with ventricular tachyarrhythmias and found that 62% of patients had 50% or greater, and 38% of patients had 90% or greater, suppression of ventricular premature contractions.7 No severe side effects were observed from berberine therapy. In humans with refractory congestive heart failure, berberine produced several significant changes: a 48% decrease in systemic and a 41% decrease in pulmonary vascular resistance, along with a 28% decrease in right atrium and 32% decrease in left ventricular end-diastolic pressures.8 A measurable increase in cardiac index (45%), stroke index (45%), and left ventricular ejection fraction (56%) were also observed. There were increases in the indices of left ventricular performance and a decrease in arteriovenous oxygen uptake (28%) with no changes in total body oxygen uptake, arterial oxygen tension, or hemoglobin dissociation properties.
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Oregano
free pdf
30) Coccimiglio, John, et al. “Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents.” (2016).
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skullcap anti inflammatory
31) Eur J Med Chem. 2017 Mar 6;131:68-80. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders.Dinda B1, Dinda S2, DasSharma S2, Banik R3, Chakraborty A4, Dinda M5.
The flavonoids, baicalin (5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-O-d-β-glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants, Scutellaria baicalensis Georgi and Oroxylum indicum (L.) Kurz in abundant quantities. The antioxidant and anti-inflammatory effects of these flavonoids have been demonstrated in various disease models, including diabetes, cardiovascular diseases, inflammatory bowel diseases, gout and rheumatoid arthritis, asthma, neurodegenerative-, liver- and kidney diseases, encephalomyelitis, and carcinogenesis.
These flavonoids have almost no toxicity to human normal epithelial, peripheral and myeloid cells. Their antioxidant and anti-inflammatory activities are largely due to their abilities to scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF-κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein-1 (MCP-1), nitric oxide synthase, cyclooxygenases, lipoxygenases, cellular adhesion molecules, tumor necrosis factor and interleukins. In this review, we summarize the antioxidant and anti-inflammatory effects of baicalin and baicalein with molecular mechanisms for their chemopreventive and chemotherapeutic applications in the treatment of inflammatory-related diseases.
Anti-Aging
32) Rejuvenation Res. 2016 Mar 15. [Epub ahead of print]
A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi.
Gao L1, Duan DD1,2, Zhang JQ1, Zhou YZ1, Qin XM1, Du GH1,3.
Aging is one of the most complicated phenomena and is the main risk factor for age-related diseases. Based on the public aging-related gene data, we propose a computational approach to predict the antiaging activities of compounds. This approach integrates network pharmacology and target fishing methods with the aim of identifying a potential antiaging compound from Scutellaria baicalensis Georgi. Utilizing this approach and subsequent experimental validation, it was found that baicalein at concentrations of 0.04, 0.2, and 1 mg/mL extended the mean, median, and maximum life spans in Drosophila melanogaster. Particularly, 0.2 mg/mL baicalein extends the mean and median life spans in male flies by 19.80% and 25.64%, respectively. Meanwhile, it was discovered that baicalein improved fertility in flies. Baicalein exerts antiaging effects likely through attenuating oxidative stress, including increases of CAT activity and GSH level and decrease of GSSG level.
Anti-atherosclerotic
33) Chan, Shih-Hung, et al. “Baicalein is an available anti-atherosclerotic compound through modulation of nitric oxide-related mechanism under oxLDL exposure.” Oncotarget 7.28 (2016): 42881.
34) Kim, Ohn Soon, et al. “Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response.” Molecular medicine reports 12.1 (2015): 1335-1341.
35) O.S. Kim, C.S. Seo, Y. Kim, H.K. Shin, H. Ha
Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response. Mol Med Rep, 12 (2015), pp. 1335–1341
Traditional herbal formulas made from Scutellariae Radix (SR), the root of Scutellaria baicalensis, have previously been used in the treatment of inflammatory diseases, such as atherosclerosis. The aim of the present study was to investigate the effects of SR on low-density lipoprotein (LDL) oxidation and inflammation in macrophages, which are early events in the development of atherosclerosis. High-performance liquid chromatography photo-diode array analysis was used to obtain a three-dimensional chromatogram of SR. The antioxidative effects of SR were evaluated by determining its scavenging activities against ABTS and DPPH radicals. The inhibitory effect of SR on LDL oxidation was examined using a thiobarbituric acid-reactive substance assay and a relative electrophoretic mobility assay. In addition, the anti-inflammatory effects of SR were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 murine macrophage cells. The results showed that SR exhibited radical-scavenging activities in a dose-dependent manner; in addition, SR attenuated the Cu2+-induced oxidation of LDL as well as significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. Furthermore, SR induced the protein expression of heme oxygenase-1 (HO-1) in RAW264.7 cells. In conclusion, the results of the present study demonstrated that SR decreased the oxidation of LDL and suppressed inflammatory responses in macrophages, which occurred at least in part via the induction of HO-1. These results therefore suggested that SR may be a potential therapeutic agent for the treatment of atherosclerosis.
Anti-Cancer Skullcap
36) Liu, Hui, et al. “The Fascinating Effects of Baicalein on Cancer: A Review.” International Journal of Molecular Sciences 17.10 (2016): 1681.
37) Wu, Xue, et al. “Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors.” OncoTargets and therapy 9 (2016): 2935.
38) Lee, Donghyun, et al. “Use of Baicalin-Conjugated Gold Nanoparticles for Apoptotic Induction of Breast Cancer Cells.” Nanoscale Research Letters 11.1 (2016): 381.
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39) Wei, L., et al. “Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.” Cell death & disease 4.4 (2013): e601.
40) Wei, L., et al. “Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization.” Cell death & disease 6.4 (2015): e1714.
41) Wang, Ke, et al. “Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.” Anti-cancer drugs 26.1 (2015): 15-24.
42) Eur J Pharmacol. 2009 Jan 28;603(1-3):22-8. Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells.Sun Y1, Lu N, Ling Y, Gao Y, Chen Y, Wang L, Hu R, Qi Q, Liu W, Yang Y, You Q, Guo Q.
Our previous study revealed that oroxylin A, a naturally occurring monoflavonoid isolated from Scutellariae radix, could inhibit the proliferation of human hepatocellular carcinoma HepG2 cells through inducing the apoptosis in these cells. However, the molecular mechanism of its anticancer activity remains poorly understood and warrants further investigations. In this study, we examined the anti-invasive activities of oroxylin A in vitro. The results showed that oroxylin A suppressed MDA-MB-435 cell adhesion to the fibronectin-coated substrate in a concentration-dependent manner. It inhibited the wound healing migration of MDA-MB-435 cells and invasion of MDA-MB-435 cells through reconstituted extracellular matrix (matrigel). Zymography revealed that oroxylin A decreased the secretion of matrix metalloproteinases-2 (MMP-2) and metalloproteinases-9 (MMP-9). Oroxylin A also inhibited the expressions of MMP-2 and MMP-9 in MDA-MB-435 cells. Additionally, oroxylin A exerted an inhibitory effect on the phosphorylation of extracellular regulated proteinkinases1/2 (ERK1/2). Collectively, these data provided a molecular basis for the antiinvasive effects of oroxylin A. Taken together, these findings strongly suggest that oroxylin A had potential anti-metastatic effect in vitro and shed light on the investigation of oroxylin A on breast cancer metastasis in vivo.
43) Li, Hua-Nan, et al. “Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo.” Toxicology 257.1 (2009): 80-85.
44) Yang, Yong, et al. “Oroxylin A induces G2/M phase cell‐cycle arrest via inhibiting Cdk7‐mediated expression of Cdc2/p34 in human gastric carcinoma BGC‐823 cells.” Journal of Pharmacy and Pharmacology 60.11 (2008): 1459-1463.
45) Hu, Yang, et al. “Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity.” Biochemical and biophysical research communications 351.2 (2006): 521-527.
46) Gao, Ying, et al. “Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation.” Journal of cancer research and clinical oncology 136.5 (2010): 667-675.
47) Mu, Rong, et al. “Involvement of p53 in oroxylin A‐induced apoptosis in cancer cells.” Molecular carcinogenesis 48.12 (2009): 1159-1169.
48) Yao, Jing, et al. “Oroxylin a prevents inflammation‐related tumor through down‐regulation of inflammatory gene expression by inhibiting NF‐κB signaling.” Molecular carcinogenesis 53.2 (2014): 145-158.
49) Hsieh, Y., et al. “The lipoxygenase inhibitor, baicalein, modulates cell adhesion and migration by up‐regulation of integrins and vinculin in rat heart endothelial cells.” British journal of pharmacology 151.8 (2007): 1235-1245.
50) Song, Xiuming, et al. “Oroxylin A, a classical natural product, shows a novel inhibitory effect on angiogenesis induced by lipopolysaccharide.” Pharmacological Reports 64.5 (2012): 1189-1199.
51) Tseng, Tzu-Ling, et al. “Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents.” PLoS One 7.10 (2012): e47403.
52) Wang, Hong, et al. “An estrogen receptor dependent mechanism of Oroxylin A in the repression of inflammatory response.” PloS one 8.7 (2013): e69555.
53) Ye, Fei, et al. “Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract.” Nutrition and cancer 57.1 (2007): 100-110.
Rosemary Anti Cancer
54) Nutrients. 2016 Nov; 8(11): 731. Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
Jessy Moore,1 Michael Yousef,1 and Evangelia Tsiani1,2,*
1Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada;
2Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada
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Curcumin Inhibits Atherosclerosis in Apo E Mouse
55) J Physiol Pharmacol. 2005 Dec;56(4):627-35.
Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice.
Olszanecki R1, Jawień J, Gajda M, Mateuszuk L, Gebska A, Korabiowska M, Chłopicki S, Korbut R.
It is widely appreciated that inflammation and oxidant stress contribute to atherogenesis. Curcumin, a polyphenolic natural compound has been reported to possess anti-inflammatory and anti-oxidant actions. We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR-double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid). Curcumin (purity>or=98%), premixed with diet, was given for 4 months at a dose of 0.3 mg/ per day/ per mouse. In this model curcumin inhibited atherogenesis, measured both by “en face” method (25,15+/-2,9% vs. 19,2+/-0,6%, panti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR-double knockout mice.
56) Henrotin, Yves, Fabian Priem, and Ali Mobasheri. “Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management.” Springerplus 2.1 (2013): 56. Curcumin new paradigm treatment osteoarthritis Henrotin Yves Springerplus 2013
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February 24, 2017
AntiViral Herbals
Herbal Antivirals
by Jeffrey Dach MD
It was about twenty years ago, and I still remember vividly an anxious middle aged man on oxygen sitting up on his stretcher in the waiting area of the Hospital Xray department outside my office. He was there for his daily chest Xray to follow his viral pneumonia. After a few days, he stopped coming down, and the hospital staff informed me he had succumbed to his illness. This was a bitter lesson that, although we doctors have effective antibiotics for bacterial pneumonia, we have no such drugs for viral pneumonia, and in fact, we have very little to offer these unfortunate people except supportive care. And yes, some people will die from viral pneumonia. Left Image Courtesy of Stephen Harrod Buhner author of Antiviral Herbals.
Although modern medicine has made considerable progress in antiviral drug discovery such as Acyclovir for Herpes virus, most cultures and ethnic groups on the planet have successfully used anti-viral medicinal plants for thousands of years. Many of these plant substances are the basis for new drug discovery.
Anti-viral plant substances are useful for prevention and treatment of a host of viruses. The mechanism is fusion inhibition, which prevents attachment of the viral capsule to the host cell membrane, thus preventing entrance of virus into the cell where replication could take place.
For example, this study investigated thymoquinone from black seed as protective for CMV (cytomegalovirus).(1) ” Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection” by Salem ML.
“In this study, antiviral effect of black seed oil (BSO) from Nigella sativa was investigated using murine cytomegalovirus (MCMV) as a model…. These results show that BSO exhibited a striking antiviral effect against CMV infection “
Herbal AntiVirals By Stephen Buhner
An excellent book on this topic was written in 2013 by Stephen Harrod Buhner on Herbal AntiVirals. This book has an excellent discussion of the Influenza epidemic of 1918 and discusses various herbal treatments for various viral diseases as well in depth discussion of each herbal. I must say the book is impressive for a number of reasons. One is the extensive reference to the medical literature as well as the ethnic herbal literature, pulling usually separated sources together. My only quibble is that reference numbers are missing in the text, so one is forced to search through the bibliography to find the reference if interested in reading it.
According to Dr. Buhner’s book, the three top anti-viral herbals are Elderberry, Licorice Root and Chinese Skull cap.
Elderberry Syrup
Perhaps the most widely available of the antiviral botanicals is Black Elderberry Syrup, which can be found at most health food stores and markets. Nature’s Way offers a version of Elderberry for little kids who pick up the weekly virus at child day care.
Licorice Root
Licorice Root is widely available at most health food stores as capsules or tinctures. Once must be careful to avoid the DGL (deglycyrrhizinated licorice root) as this form has the active ingredient removed. Douglas Labs offers a licorice capsule which Dr Buhner recommends: Licorice Root-V, standardized to 12% glycyrrhizin per each 500 mg capsule. I have given this product to family members during viral illness with good results. Licorice Root is also available from various herbal apothecaries as tinctures. More on that later.
Chinese Skullcap
Dr Buhner reminds us to avoid the American Skullcap which is a different species and less effective than Chinese skullcap which contains the active ingredients Baicalin and Baicalein. American skullcap is called Scutellaria lateriflora whereas the correct one, the Chinese skullcap, is called Scutellaria baicalensis. The Chinese Skullcap comes as a dried root, and best used as a tincture prepared in alcohol. Dr Buhner lists a number of herbal apothecaries that he likes for the tinctures.
[image error] Woodland Essence
offers a number of tinctures. I ordered the separate tinctures for Baikal Skullcap (Chinese skullcap) and the Licorice dried root tincture. (see image at left). I made tea with hot water and both tinctures mixed with Black Elderberry Syrup to help get over a flu big I had. I think it helped, as I felt better after each dose of tea. Woodland Essence Web Site.
[image error] Elk Mountain Herbs
Located in Laramie Wyoming, Elk Mountain Herbs offers a product called Elderberry Plus (see image at left). This contains concentrated elderberry tea, raw cheyenne honey, tinctures of boneset, Baikal Skullcap, ginger and fresh lemon juice. I ordered the licorice root tincture separately, as together this contains most of the antiviral ingredients recommended in Dr Buhner’s book. Perhaps the honey and lemon juice makes this the best tasting and palatable of this group. Here is the label on the bottle:
[image error] Left Image label for Elderberry Plus from Elk Mountain Herbals.
Sage Woman Consulting and Apothecary
[image error] [image error] Sage Woman Apothecary offers the EBV formula which is perhaps the most true to Dr Buhner’s herbal anti-viral recipe, as you can see from the label. This EBV contains the top ingredients, the Scutellaria baicalensis (Chinese skulcap), and glycyrrhiza glabra (Licorice Root) . In addition a host of other anti-virals are added:Isais indigota, Rhodiola rocea, Ganodermum lucidum, Lomatium dissectum, Pueraria rhizome. Although the name EBV, refers to Epstein Barr Virus, the formulas are similar so this may also be used for most other viruses such as Influenza, RSV, respiratory syncytial virus etc.
Unlike the other two web sites which are solely ordering sites and do not return phone calls, Sage Woman Consulting actually called me back to discuss my order.
This list of herbal anti-virals is by no means final, as there are perhaps hundreds more, such as Olive Leaf, Garlic, Artemisinin, Berberine etc.
One should also rememeber the importance of replenishing vitamin C and selenium levels in the critically ill patient with pneumonia as discussed in my previous article.
Buy Book on Amazon: Herbal Antivirals by Stephen Harrod Buhner
Articles with Related Interest
Vitamin C saves Man Dying of Viral Pneumonia
Antibiotic Resistant Super Bugs
Links and References
1) CMV https://www.ncbi.nlm.nih.gov/pubmed/10884593
Int J Immunopharmacol. 2000 Sep;22(9):729-40.
Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection.
Salem ML1, Hossain MS.
In this study, antiviral effect of black seed oil (BSO) from Nigella sativa was investigated using murine cytomegalovirus (MCMV) as a model. The viral load and innate immunity mediated by NK cells and Mφ during early stage of the infection were analyzed. Intraperitoneal (i.p.) administration of BSO to BALB/c mice, a susceptible strain of MCMV infection, strikingly inhibited the virus titers in spleen and liver on day 3 of infection with 1×10(5) PFU MCMV. This effect coincided with an increase in serum level of IFN-gamma. Although BSO treatment decreased both number and cytolytic function of NK cells on day 3 of infection, it increased numbers of Mφ and CD4(+) T cells. On day 10 of infection, the virus titer was undetectable in spleen and liver of BSO-treated mice, while it was detectable in control mice. Although spleen of both control and BSO-treated mice showed similar CTL activities on day 10 after infection, serum level of IFN-gamma in BSO-treated mice was higher. Furthermore, BSO treatment upregulated suppressor function of Mφ in spleen. These results show that BSO exhibited a striking antiviral effect against MCMV infection which may be mediated by increasing of Mφ number and function, and IFN-gamma production.
2) http://www.herbalmedicinehealing.com/php
Stephen Harrod Buhner is an Earth poet and the award-winning author of ten books on nature, indigenous cultures, the environment, and herbal medicine. He comes from a long line of healers including Leroy Burney, Surgeon General of the United States under Eisenhower and Kennedy, and Elizabeth Lusterheide, a midwife and herbalist who worked in rural Indiana in the early nineteenth century. The greatest influence on his work, however,has been his great-grandfather C.G. Harrod who primarily used botanical medicines, also in rural Indiana, when he began his work as a physician in 1911
3) Jassim, S. A. A., and Mazen A. Naji. “Novel antiviral agents: a medicinal plant perspective.” Journal of Applied Microbiology 95.3 (2003): 412-427. Novel antiviral agents medicinal plant perspective Journal Applied Microbiology Jassim and Mazen 2003
Virtually all cultures around the globe have relied
historically, and continue to rely on medicinal plants for
primary health care.
4) https://www.ncbi.nlm.nih.gov/pubmed/8847882
J Ethnopharmacol. 1995 Dec 1;49(2):101-10.
Antiviral screening of British Columbian medicinal plants.
McCutcheon AR1, Roberts TE, Gibbons E, Ellis SM, Babiuk LA, Hancock RE, Towers GH.
One hundred methanolic plant extracts were screened for antiviral activity against seven viruses. Twelve extracts were found to have antiviral activity at the non-cytotoxic concentrations tested. The extracts of Rosa nutkana and Amelanchier alnifolia, both members of the Rosaceae, were very active against an enteric coronavirus. A root extract of another member of the Rosaceae, Potentilla arguta, completely inhibited respiratory syncytial virus. A Sambucus racemosa branch tip extract was also very active against respiratory syncytial virus while the inner bark extract of Oplopanax horridus partially inhibited this virus. An extract of Ipomopsis aggregata demonstrated very good activity against parainfluenza virus type 3. A Lomatium dissectum root extract completely inhibited the cytopathic effects of rotavirus. In addition to these, extracts prepared from the following plants exhibited antiviral activity against herpesvirus type 1: Cardamine angulata, Conocephalum conicum, Lysichiton americanum, Polypodium glycyrrhiza and Verbascum thapsus.
5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663710/
Ganjhu, Rajesh Kumar, et al. “Herbal plants and plant preparations as remedial approach for viral diseases.” Virusdisease 26.4 (2015): 225-236.
6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032839/
Lin, Liang-Tzung, Wen-Chan Hsu, and Chun-Ching Lin. “Antiviral natural products and herbal medicines.” Journal of traditional and complementary medicine 4.1 (2014): 24-35.
7) http://www.wildernesscollege.com/antiviral-herbs.html
Antiviral Herbs by Gabe Garms
8) https://draxe.com/antiviral-herbs/
Use Antiviral Herbs to Boost Immune System & Fight Infection
9) https://www.ncbi.nlm.nih.gov/pubmed/9395631
J Altern Complement Med. 1995 Winter;1(4):361-9.
Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. Zakay-Rones Z1, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M.
10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193558/
Evid Based Complement Alternat Med. 2005 Sep; 2(3): 309–314.
Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice. Sandra C. Miller
Echinacea has been viewed as an immunoenhancing herb since it became commercially available several years ago. Indeed, its medicinal significance is responsible for billions of dollars in worldwide sales annually. Unfortunately, most of the ‘evidence’ for the purported medicinal efficacy of Echinacea has been anecdotal and, moreover, to this day, there is no formal proof on how to achieve the best results—whether it should be consumed daily throughout life as a prophylactic; consumed by either young or old; or consumed after diseases, such as cancer, have taken hold. Our work over the past 5 years has led to conclusive answers to some of these questions, at least in mice. Our results have shown that daily consumption of Echinacea is indeed prophylactic, extends the life span of aging mice, significantly abates leukemia and extends the life span of leukemic mice. Given that humans are 97% genetically common with mice and that virtually all our basic physiology is identical, it is neither unjustified to extrapolate these observations to humans nor would it be an arduous task to perform many of these studies in humans, thus establishing viable scientific evidence replacing the anecdotal.
11) https://www.ncbi.nlm.nih.gov/pubmed/24520776
Bing Du Xue Bao. 2013 Nov;29(6):673-9.
[Anti-virus research of triterpenoids in licorice].
[Article in Chinese]
Pu JY1, He L2, Wu SY2, Zhang P2, Huang X2.
Licorice is a leguminous plant of glycyrrhiza. It is a traditional Chinese herbal medicine. Triterpenoid is one of the mainly active components of licorice. In recent years, the broad-spectrum antiviral activity of many triterpenoids in licorice was confirmed, and these findings have become a hot spot of antiviral immunity. The triterpenoids of licorice has the potential to become a novel broad-spectrum antiviral medicine and will be widely used in the clinical treatment. This review provided a summary of the recent anti-virus research progress on several triterpenoids in licorice, such as glycyrrhizic acid, glycyrrhizin, glycyrrhetinic acid and its derivatives. The antiviral roles of triterpenoids in licorice against herpes virus, HIV, hepatitis virus, SARS coronavirus and influenza virus were briefly summarized.
12) http://www.sciencedirect.com/science/article/pii/S030881461000244X
Cheel, José, et al. “Free radical-scavenging, antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L.).” Food chemistry 122.3 (2010): 508-517.
13) http://www.thesurvivalistblog.net/herbal-medicine-influenza-pandemics/
Herbal Medicine: Influenza Pandemics and the Cytokine Storm by Michele and edited by Bam Bam February 26, 2014 By M.D. Creekmore
elderberry keeps the virus from attaching to the cell walls so it is unable to enter the cell and replicate.
=============================
anti-viral botanicals
14) Glycyrrhiza glabra.(licorice) root higher glycyrrhizin content,
https://www.standardprocess.com/Products/MediHerb/Licorice-High-Grade-11#.WJ8bgX-bxPY
15) douglass labs 500 mg caps 2 caps three times a day.
16) Skullcap baicalensis root
https://www.standardprocess.com/Products/MediHerb/Skullcap-12#.WJ8cM3-bxPY
17) ginger root fresh juice (see article below)
J Ethnopharmacol. 2013 Jan 9;145(1):146-51. doi: 10.1016/j.jep.2012.10.043. Epub 2012 Nov 1.
Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines.
Chang JS1, Wang KC, Yeh CF, Shieh DE, Chiang LC.
Ginger, Zingiber officinale Roscoe, is a common spice and also a widely used medicinal plant in ancient China. Ginger is an ingredient of Ge-Gen-Tang (Kakkon-to; GGT). GGT has been proved to have antiviral activity against human respiratory syncytial virus (HRSV). However, it is unknown whether ginger is effective against HRSV.
AIM OF THE STUDY:To find a readily available agent to manage HRSV infection, the authors tested the hypothesis that ginger can effectively decrease HRSV-induced plaque formation in respiratory mucosal cell lines.
MATERIALS AND METHODS:Effect of hot water extracts of fresh and dried gingers on HRSV was tested by plaque reduction assay in both human upper (HEp-2) and low (A549) respiratory tract cell lines. Ability of ginger to stimulate anti-viral cytokines was evaluated by enzyme-linked immunosorbent assay (ELISA).
RESULTS:Fresh ginger dose-dependently inhibited HRSV-induced plaque formation in both HEp-2 and A549 cell lines (p
CONCLUSIONS:Fresh, but not dried, ginger is effective against HRSV-induced plaque formation on airway epithelium by blocking viral attachment and internalization.
elderberry syrup
18) Skullcap baicalensis root
https://www.standardprocess.com/Products/MediHerb/Skullcap-12#.WJ8cM3-bxPY
19) (www.elkmountainherbs.com)
20) (www.woodlandessence.com).
21) Respiratory Syncytial Virus Respiratory syncytial virus is also a single-strand, enveloped RNA virus with high variation in its genome. It is a very common infection, especially in young children, throughout the world. It causes bronchiolitis and other types of respiratory infections, especially in the lower respiratory tract. It generally presents as a common cold but can sometimes become serious, turning into pneumonia if left untreated. The herbs specific for respiratory syncytial virus infections are Chinese skullcap, Eleutherococcus senticosus, elder, isatis, licorice, and Sophora flavescens. Other herbs found active are Barleria prionitis, Blumea laciniata, Elephantopus scaber, Laggera pterodonta, Markhamia lutea, Mussaenda pubescens, Narcissus tazetta, Selaginella sinensis, Scutellaria indica, and Schefflera octophylla (in vitro). Treatment: The same as for mild influenza. If it becomes serious, the same as for moderate to severe influenza.
Yarnell, Eric. “Herbs for Emerging Viral Infectious Diseases.” Alternative and Complementary Therapies 22.4 (2016): 164-174.
Several coronavirus (severe acute respiratory syndrome [SARS], Middle East respiratory syndrome [MERS]), flavivirus (yellow fever, West Nile, dengue, Zika), and alphavirus (chikungunya, Ebola) infections have, in the past 10–20 years, emerged or reemerged as major problems across large regions of the globe. While, currently, many of these infections are confined to the tropics, global warming, the spread of some mosquito vectors northward, and emergence of temperate-tolerant pathogens such as West Nile virus mean that these problems are increasingly affecting the global north as well. After discussing mosquito-based preventions for the zoonotic infections mentioned in this article, a review of herbal responses to the SARS and MERS epidemics are highlighted. Houttuynia cordata (houttuynia, yú xīng cǎo) and Glycyrrhiza spp. (licorice) stand out as particularly interesting single herbs for addressing these coronavirus infections. Herbal approaches to flavivirus infections, most notably clinical trials of Carica papaya (papaya) leaves for treating dengue fever, are reviewed. A discussion of many of the extensive range of herbs studied to treat flaviviruses in preclinical studies is provided. Potential herbal treatments for alphavirus infections are then presented.
https://www.ncbi.nlm.nih.gov/pubmed/2...
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.
Varghese FS1, Kaukinen P1, Gläsker S2, Bespalov M3, Hanski L4, Wennerberg K3, Kümmerer BM2, Ahola T5.
Chikungunya virus (CHIKV) is an arthritogenic arbovirus of the Alphavirus genus, which has infected millions of people after its re-emergence in the last decade. In this study, a BHK cell line containing a stable CHIKV replicon with a luciferase reporter was used in a high-throughput platform to screen approximately 3000 compounds. Following initial validation, 25 compounds were chosen as primary hits for secondary validation with wild type and reporter CHIKV infection, which identified three promising compounds. Abamectin (EC50 = 1.5 μM) and ivermectin (EC50 = 0.6 μM) are fermentation products generated by a soil dwelling actinomycete, Streptomyces avermitilis, whereas berberine (EC50 = 1.8 μM) is a plant-derived isoquinoline alkaloid. They inhibited CHIKV replication in a dose-dependent manner and had broad antiviral activity against other alphaviruses–Semliki Forest virus and Sindbis virus. Abamectin and ivermectin were also active against yellow fever virus, a flavivirus. These compounds caused reduced synthesis of CHIKV genomic and antigenomic viral RNA as well as downregulation of viral protein expression. Time of addition experiments also suggested that they act on the replication phase of the viral infectious cycle.
https://www.ncbi.nlm.nih.gov/pubmed/1...
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1562-4. Epub 2007 Jan 4.
Antiviral activity of berberine and related compounds against human cytomegalovirus.
Hayashi K1, Minoda K, Nagaoka Y, Hayashi T, Uesato S.
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.
https://www.ncbi.nlm.nih.gov/pubmed/2...
Arch Virol. 2010 Dec;155(12):1933-41. doi: 10.1007/s00705-010-0779-9. Epub 2010 Aug 5.
Anti-herpes simplex virus effects of berberine from Coptidis rhizoma, a major component of a Chinese herbal medicine, Ching-Wei-San.
Chin LW1, Cheng YW, Lin SS, Lai YY, Lin LY, Chou MY, Chou MC, Yang CC.
Berberine is an alkaloid extracted from Coptidis rhizome. Among the individual herbal components of a Chinese herb medicine, Ching-Wei-San, Coptidis Rhizoma has the most potent antimicrobial activity. By high-pressure liquid chromatography, the quantitative analysis of berberine from 6.25-mg/mL (w/v) Coptidis rhizome extract or 50.00-mg/mL (w/v) Ching-Wei-San was determined to be 0.26 mg/mL. To explore the potential use of Ching-Wei-San against herpes simplex virus (HSV) infection, the cytotoxicity, anti-HSV-1 and anti-HSV-2 activity in Vero cells were assayed. The selectivity index of berberine was about 1.2-1.5 times higher than that of Coptidis rhizome extract and Ching-Wei-San. Moreover, the antiviral activities correspond to the content of berberine in the aqueous solution. Berberine may interfere with the viral replication cycle after virus penetration and no later than the viral DNA synthesis step, and its activities were not affected by the preparation processes. Berberine, the natural plants that contain this component, including Coptidis rhizome, and Ching-Wei-San have all shown anti-HSV effects.
https://www.ncbi.nlm.nih.gov/pubmed/2...
Chin J Integr Med. 2011 Jun;17(6):444-52. doi: 10.1007/s11655-011-0640-3. Epub 2011 Jun 10.
In vivo and in vitro antiviral effects of berberine on influenza virus.
Wu Y1, Li JQ, Kim YJ, Wu J, Wang Q, Hao Y.
To explore the potential effects of berberine on influenza virus infection both in vitro and in vivo.
METHODS:In vitro anti-influenza virus assays were performed by cytopathogenic effect and neuraminidase assays in Madin Darby canine kidney cells. In vivo anti-influenza virus assays were performed on the viral pneumonia model of mice. The numbers of mice that died within day 2 to day 14 postinfection were recorded to calculate the mortality. On days 2, 4, and 6, the viral titers in the lungs were determined by hemagglutination assay; hematoxylin/eosin staining was used to assess the pathogenic changes of lung tissues; the concentrations of tumor necrosis factor-alpha (TNF-α) and monocyte specific chemoattractant molecule (MCP-1) were measured by radio immunoassay or enzyme-linked immunosorbent assay; the concentrations of nitric oxide (NO) and inducible nitric oxide synthetase (iNOS) were detected by colorimetric method; reverse transcription polymerase chain reaction was used to detect the mRNA level of TNF-α and MCP-1.
RESULTS:Berberine showed inhibitory effects on cytopathogenic effects and neuraminidase activity of virus, with the therapeutic index 9.69. In vivo, berberine decreased mice mortality from 90% to 55%, reduced virus titers in the lungs on day 2 postinfection (P
CONCLUSIONS:Berberine exhibited antiviral effects on the influenza virus both in vitro and in vivo. The possible therapeutic mechanism of berberine on influenza-induced viral pneumonia might be inhibiting the virus infection, as well as improving the pathogenic changes by repressing inflammatory substances release.
Buhner, Stephen Harrod. Herbal Antivirals: Natural Remedies for Emerging & Resistant Viral Infections (Kindle Locations 1034-1043). Storey Publishing, LLC. Kindle Edition.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
www.jeffreydachmd.com
www.drdach.com
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
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The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Link to this article: http://wp.me/p3gFbV-4VR
Copyright (c) 2017 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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February 23, 2017
Mike Adams Natural News Black Listed by Google
Mike Adams Natural News Black Listed by Google Search Engine
by Jeffrey Dach MD
Breaking News: Mike Adams Natural News web site has been black listed by Google. This means all of the 140,000 pages on the Natural News web site have been deleted from Google search results. This is a form of authoritarian censorship found in dictatorship countries like communist China, Stalinist Russia and of course, Nazi Germany.
I don’t always agree with everything on the Natural News Web site, however, I respect their right to say it.
Information War Escalates to New Level
Free speech censorship could never happen in a free society which enjoys freedom of speech protected by constitutional rights. Obviously, this indicates we do not have freedom of speech on the internet. This form of censorship indicates the “information war” has escalated to a new level, and is a very bad omen for things to come.
Mike Adams of Natural News
Remarks on Being Blacklisted by Google:
Articles with related Interest:
Bioidentical Hormones Oppsed by Endocrine Society-Bananas
Why are one in six on Psych Meds ?
Links and References:
1) Mike Adams Natural News
2) Independent Search Engine GoodGopher.com
3) Erin Health Nut News Google blacklists Natural News… removes 140,000 pages from its index…By Erin Elizabeth -February 22, 2017
4) Mother Earth News GOOGLE blacklists Natural News…
The post Mike Adams Natural News Black Listed by Google appeared first on Jeffrey Dach MD.
February 12, 2017
Medical Ghostwriting Deemed a Fraud on the Court
Medical Ghostwriting Deemed a Fraud on the Court
by Jeffrey Dach MD
Stern and Lemmens, two Toronto Law Professors, have joined forces in a scathing denouncement of medical ghostwriting in the August 2 PLOS journal.(1) The two law professors cited a 1944 Supreme Court case dealing with ghost writing, Hazel-Atlas Glass v. Hartford-Empire Co. (1944).
In this patent dispute case, the Supreme Court was fooled by a ghost written trade article presented in defense of a patent. A few years later, when Anti-Trust litigation revealed that the article had been “ghost written”, the Court overturned the patent decision, and ruled that ghost writing in the trade literature amounted to a “fraud on the court”, and the lawyers who had used the “ghost written” article were disbarred from practice.(2) This same concept applies to the pharmaceutical industry. Above left image: Ghost Image on cover of old comic book courtesy of wikimedia commons.
Current examples of ghost writing by the drug industry planted into the medical literature include drugs such as:
1) Vioxx (rofecoxib) a heavily promoted anti-inflammatory NSAID drug, later found to cause heart attacks.(3)(10-11)
2) Prempro (combined estrogen/progestin), a synthetic hormone combination drug heavily promoted for years as hormone replacement for women. This was found to cause cancer and heart disease in the WHI (Women’s Health Initiative Study).(4)(12-13)
3) Paxil (paroxetine), an SSRI antidepressant found to be no better than placebo for most patients in treatment for depression, and also found to cause suicidal impulses (5,6).
There are many others.This quote is from the Adriane J. Fugh-Berman article.(4)
“Ghostwriting has been documented for drugs other than Prempro. For example, Forest Laboratories’ 2004 marketing plan for Lexapro (escitalopram) [95], stated: “Bylined articles will allow us to fold Lexapro messages into articles on depression, anxiety and comorbidity developed by (or ghostwritten for) thought leaders” [96]. Ghostwriting has also been documented in the promotion of Paxil (paroxetine) [97]–[100], “Fen-phen” (fenfluramine and phentermine) [101], Neurontin (gabapentin) [102], Vioxx (rofecoxib) [103], and Zoloft (sertraline) [104].”
Examples of Fraud – Ghost Writing in the Synthetic HRT medical literature from Adriane J. Fugh-Berman (4)
Mitigating Perceived Risks of Breast Cancer- Fraud
Nachtigall LE. Sex Hormone-Binding Globulin and Breast Cancer Risk
Primary Care Update for Ob/Gyns 1999; 6 (2):39-45.
Eden J. Progestins and breast cancer. Am J Obstet Gynecol. 2003
May;188(5):1123-31.
Cefalu T. The Use of Hormone Replacement Therapy in Postmenopausal Women with Type 2 Diabetes. J Women’s Health 2001; 10 (3):241-255
Promoting Off-Label Uses for Alzheimers’, Parkinsons– Fraud
Fillit, M. The Role of Hormone Replacement Therapy in the Prevention of Alzheimer Disease. Arch Intern Med. 2002;162(17):1934-42.
Birge SJ. Practical Strategies for the Diagnosis and Treatment of Alzheimer’s Disease. Clinical Geriatrics 1999 7(4):56-74.
Shulman L. Is there a Connection Between Estrogen and Parkinson’s Disease? Parkinsonism Relat Disord. 2002;8(5): 289-95
Sherwin BB. Mild Cognitive Impairment: Potential Pharmacological Treatment Options. J Am Geriatr Soc. 2000;48(4):431-41.
Brincat M, Baron Y, Galea R. Estrogens and the Skin. Climacteric 2005;8(2):110-23.
Snow KK, Seddon JM. Age-Related Eye Diseases: Impact of Hormone Replacement Therapy and Other Risk Factors. Int J Fertil Womens Med. 2000 Sep-Oct;45(5):301-13
Freedman, MA. Quality of Life and Menopause: The Role of Estrogen. J Women’s Health 2002;11(8):703-718.
Bachman G, Leiblum S. The Impact of Hormones on Menopausal Sexuality: a Literature Review. Menopause 2004;11 (1): 120-130.
Mitigating Perceived Risks of Breast Cancer
Curtis M. Selective Estrogen Receptor Modulators: A Controversial Approach for Managing Postmenopausal Health. J Women’s Health 1999; 8 (3) : 321-33
Curtis MG. Comparative Tolerability of First-Generation Selective Estrogen Receptor Modulators in Breast Cancer Treatment and Prevention. Drug Safety 2001;24(14):1039-53
Bachmann GA. Menopausal Vasomotor Symptoms: a Review of Causes, Effects and evidence-Based Treatment, J Reprod Med. 2005 Mar;50(3):155-65.
Ansbacher R. The Pharmacokinetics and Efficacy of Different Estrogens are Not Equivalent. Am J Obstet Gynecol. 2001 Feb;184(3):255-63
No author listed. Generic and Therapeutic Substitution. National Pharmacy Compliance News 2000;4th quarter:2-3.
Defending Cardiovascular Benefits – Fraud
Mosca L. Hormone Replacement Therapy in the Prevention and Treatment of Atherosclerosis. Curr Atherosclerosis Reports 2000 Jul;2(4):297-302.
Rackley CE. New clinical markers predictive of cardiovascular disease: the role of inflammatory mediators. Cardiol Rev. 2004;12(3):151-7.
Koh KK. Can a Healthy Endothelium Influence the Cardiovascular Effects of Hormone Replacement Therapy? Int J Cardiol. 2003;87(1):1-8
Positioning Low-dose Therapy – Fraud
Lobo R, Whitehead M. Is Low-Dose Hormone Replacement Therapy for Postmenopausal Women Efficacious and Desirable? Climacteric. 2001 Jun;4(2):110-9.
Maddox RW. The Efficacy and Safety of Low-dose Hormone Therapy. US Pharmacist 2004 (June).
Guilty of Fraud on the Court
The above are fraudulent ghostwritten articles were “planted” into the medical literature.(4) They were written by paid authors from Designwrite, and academic “opinion leaders” were selected to lend their name as author to sway the opinions of others. These “opinion leaders” are all guilty of “Fraud on the Court”.
Bioidentical Hormones are Safe and Effective
Bioidentical Hormones are safer and more effective than synthetic chemically altered hormones. Smart women have abandoned synthetic hormones, and have turned to bioidentical hormones as safe and effective. What convinced them?
1) The revelations of ghostwriting in the HRT literature.
2) The many medical studies showing synthetic hormones cause cancer and heart disease.
3) The many medical studies showing safety and efficacy of bioidentical hormones.
4) The decrease in breast cancer rates of 9% in the years 2003-2004 after the WHI study was terminated early because of increased breast cancer in the Prempro group.
Articles with related interest:
Bioidentical Hormones and Medical Ghost Writing, the Latest Scandal
Why is My Doctor Opposed to Bioidentical Hormones?
HRT Does Not Cause Breast Cancer
References
1) Stern, Simon, and Trudo Lemmens. “Legal remedies for medical ghostwriting: imposing fraud liability on guest authors of ghostwritten articles.” PLoS Med 8.8 (2011): e1001070.
2) Hazel-Atlas Co. v. Hartford Co., 322 U.S. 238, 64 S. Ct. 997, 88 L. Ed. 1250 (1944).
3) FDA NEWS RELEASE September 30, 2004
FDA Issues Public Health Advisory on Vioxx as its Manufacturer Voluntarily Withdraws the Product
4) Fugh-Berman, Adriane J. “The haunting of medical journals: how ghostwriting sold “HRT”.” PLoS Med 7.9 (2010): e1000335. The haunting of medical journals how ghostwriting sold HRT Fugh-Berman Adriane J PLoS Med 2010
4a) JAMA. 2003;289(24):3243-3253 Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women – The Women’s Health Initiative Randomized Trial by Rowan T. Chlebowski, MD, PhD; et al for the WHI Investigators Influence of Estrogen Plus Progestin on Breast Cancer in Postmenopausal Womens Health Initiative Chlebowski Rowan T Jama 2003
5) SSRI Antidepressants no better than Placebo JAMA Article
6) Culpepper, Larry, et al. “Suicidality as a possible side effect of antidepressant treatment.” Primary care companion to the Journal of clinical psychiatry 6.2 (2004): 79.
7) Bosch, Xavier, Bijan Esfandiari, and Leemon McHenry. “Challenging medical ghostwriting in US courts.” PLoS Med 9.1 (2012): e1001163.
9) Schofferman, J., F. T. Wetzel, and C. Bono. “Ghost and guest authors: you can’t always trust who you read.” Pain medicine (Malden, Mass.) 16.3 (2015): 416.
10) Ghostwriters Used in Vioxx Studies, Article Says
By STEPHANIE SAULAPRIL 15, 2008
11) Krumholz, Harlan M., et al. “What have we learnt from Vioxx?.” BMJ: British Medical Journal 334.7585 (2007): 120. What have we learnt from Vioxx Krumholz Harlan M BMJ 2007
12) Medical Papers by Ghostwriters Pushed Therapy By NATASHA SINGER August 4, 2009
13) Bosch, Xavier. “Exorcising ghostwriting….” EMBO reports 12.6 (2011): 489-494.
Jeffrey Dach MD
7450 Griffin Road, Suite 190
Davie, Fl 33314
954-792-4663
www.jeffreydachmd.com
www.drdach.com
www.naturalmedicine101.com
www.bioidenticalhormones101.com
www.truemedmd.com
Disclaimer click here: www.drdach.com/wst_page20.html
The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician. Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician — patient relationship. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur.
Link to this article: http://wp.me/p3gFbV-4UQ
Copyright (c) 2017 Jeffrey Dach MD All Rights Reserved. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given.
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a ‘fair use’ of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.
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January 18, 2017
Antibiotic Resistant Super Bugs
Antibiotic Resistant Super Bugs
by Jeffrey Dach MD
The news media reported a Nevada women who succumbed to bacterial infection with an antibiotic resistant super bug called CRE, short for carbapenem-resistant Enterobacteriaceae. (1-7)
Normally, antibiotics are quite effective for bacterial infection. However, this Super-Bug had acquired new abilities to resist 26 different antibiotics. How do these super bugs evolve so fast? Antibiotic Resistance is obtained as a trait from other bacteria with the exchange of genetic material called Plasmids. This is called horizontal gene transfer. Sooner or later, every new antibiotic meets with resistant organisms and we need to come up with a new antibiotic. Above image SEM of E Coli courtesy of wikimedia commons.
Natural Antibiotics to the Rescue
Perhaps this unfortunate Nevada patient might have fared better, and may have survived if only her hospital doctors had acquired a copy of the book, Herbal Antibiotics, Natural Alternatives for Treating Drug-resistant Bacteria by Stephen Harrod Buhner .
This book explains exactly what to do if the antibiotics don’t work.
Buhner’s book explains how natural antibiotics are effective alternatives for antibiotic resistant infections. Mr Buhner is a prolific writer and an expert on natural plant antibiotics effective even in the case of antibiotic resistant microbes.(8-10) Left Image Microscopic image of E Coli Courtesy of Wikimedia Commons.
There are so many antimicrobial plant substances, we can’t list them all Here are a few from Dr Buhner’s book:
Herbal Alternatives to Antibiotics
Systemic Herbs
For systemic infections, resistant staph, MRSA, tuberculosis and malaria. etc.
Cryptolepis (Cryptolepis sanguinolenta)
Sida (Sida acuta)
Alchornea (Alchornea cordifolia)
Bidens (Bidens pilosa)
Artemisia (Artemisia annua)
Non-Systemic Herbs
For antibiotic resistant infections of the GI tract, urinary tract and skin.
American goldenseal (Hydrastis canadensis) Goldenseal : active against E. coli and salmonella.
Juniper (Juniperus spp.)
Usnea (Usnea spp.)
Honey
Synergistic Herbs
enhance immune function.
Licorice (Glycyrrhiza glabra and G. uralensis)
Ginger (Zingiber officinale)
Black pepper (Piper nigrum and P. longum)
In Conclusion:
We should not be discouraged by the news media reports of antibiotic resistant bacteria killing us off one by one. Very effective treatments with natural antibiotics are available in case the synthetic antibiotics stop working. Your hospital based medical system just doesn’t know about it yet.
Articles with Related Interest
Oregano for Travelers Diarrhea
Jeffrey Dach MD
Links and References
1) No Antibiotic In The U.S. Could Save This Woman. We Should All Be Worried. This is one of the first cases of a pan-resistant infection in America. 01/13/2017 09:57 pm ET Huffington Post
2) Infectious Disease. A Superbug That Resisted 26 Antibiotics
January 17, 20173:01 PM ET Susan Brink
3) Study: CRE could be spreading more widely than we think
Filed Under: Antimicrobial Stewardship
4) Think antibiotic-resistant ‘super-bugs’ are only a distant threat? Think again. PRI’s The World January 17, 2017 · 4:00 PM EST
5) A Nevada woman dies of a superbug resistant to every available antibiotic in the US By Helen Branswell January 12, 2017
6) New CDC Vital Signs: Lethal, Drug-resistant Bacteria Spreading in U.S. Healthcare Facilities
Drug-resistant germs called carbapenem-resistant Enterobacteriaceae, or CRE, are on the rise and have become more resistant to last-resort antibiotics during the past decade, according to a new CDC Vital Signs report. These bacteria are causing more hospitalized patients to get infections that, in some cases, are impossible to treat.
CRE are lethal bacteria that pose a triple threat:
Resistance: CRE are resistant to all, or nearly all, the antibiotics we have – even our most powerful drugs of last-resort.
Death: CRE have high mortality rates – CRE germs kill 1 in 2 patients who get bloodstream infections from them.
Spread of disease: CRE easily transfer their antibiotic resistance to other bacteria. For example, carbapenem-resistant klebsiella can spread its drug-destroying weapons to a normal E. coli bacteria, which makes the E.coli resistant to antibiotics also. That could create a nightmare scenario since E. coli is the most common cause of urinary tract infections in healthy people.
7) Jan 15, 2017 Forbes
Woman Dies From Bacteria Resistant To All Antibiotics: Why Don’t More People Care?
Welcome to the future…a bad future. In September 2016, a female in her 70s died from an infection caused by carbapenem-resistant Enterobacteriaceae (CRE), bacteria that was resistant to all available antibiotics. Yes, resistant to all available antibiotics. Yes, doctors could do nothing to stop her infection.
12 Herbal Alternatives to Antibiotics
Stephen Harrod Buhner recommends these 12 herbs in his book Herbal Antibiotics (Storey Publishing, 2011). Systemic Herbs These five systemic herbs can be very helpful in treating systemic infections such as resistant staph, MRSA, tuberculosis and malaria. • Cryptolepis (Cryptolepis sanguinolenta) • Sida (Sida acuta) • Alchornea (Alchornea cordifolia) • Bidens (Bidens pilosa) • Artemisia (Artemisia annua) Non-Systemic Herbs These three localized non-systemic herbs treat resistant infections of the GI tract, urinary tract and skin.
• American goldenseal (Hydrastis canadensis) Goldenseal is also particularly active against most food poisoning bacteria such as E. coli and salmonella.
• Juniper (Juniperus spp.) • Usnea (Usnea spp.) • Honey
Synergistic Herbs Synergistic herbs increase the activity of other herbs. These three will boost inactive resistant bacteria mechanisms, increase the presence of antibacterial agents in the body and enhance immune function. • Licorice (Glycyrrhiza glabra and G. uralensis) • Ginger (Zingiber officinale) • Black pepper (Piper nigrum and P. longum)
9) Herbal Antibiotics, 2nd Edition: Natural Alternatives for Treating Drug-resistant Bacteria Paperback – July 17, 2012
by Stephen Harrod Buhner (Author)
10) Herbal Antibiotics: An Effective Defense Against Drug-Resistant ‘Superbugs’ . As the antibiotic-resistant bacteria known as “superbugs” become more numerous and more virulent, herbal medicine offers an alternative to increasingly ineffective drugs.
by Stephen Harrod Buhner December 2013/January 2014
11) What You Need to Know About the Deadly Superbug Infection Resistant to All FDA-Approved Antibiotics By Gillian Mohney ABC News Jan 16, 2017, 1:33 PM ET
Jeffrey Dach MD
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January 13, 2017
Donald Trump, Autism, Vaccination and Robert Kennedy Jr.
Donald Trump, Autism, Vaccination and Robert Kennedy Jr.
I attended a meeting where the keynote speaker David Katz MD spoke on “Feet, Forks and FIngers” (1) In short, we are killing ourselves by smoking, eating the wrong foods, and not enough exercise. Although this message is important, perhaps Dr Katz has been beating this drum too long. A little variation would keep his audience more engaged. It occurred to me that other public health issues also deserve attention, such as the increasing prevalence of autism, now one in 68 children.(2) Upper image Donald Trump and Robert Kennedy Jr courtesy of NBC Connecticut.
Autism, a Public Health Issue
After the talk, we met the speaker at the back of the hall and ask questions. I approached Dr Katz, introduced myself and asked:
“Wouldn’t you consider increasing autism rate a public health issue? As a member of the public health academic community, why are you not speaking about it? Why didn’t you mention the increasing autism rate in your presentation today? Shouldn’t the public health academic community be leading the way in finding the cause for our increasing autism epidemic?”(3,4)
After an awkward moment of silence, Dr Katz shuffled around and said he really had no answer for my question. I was not surprised by this, as today’s political climate has forced our public health professors and academics into hiding on this issue.
Enforcing Discipline
Authoritarian rulers typically enforce discipline by making an example of dissenters, who are accused of being “enemies of the state” and summarily executed. Such an example was made of Dr Wakefield whose career was destroyed after his research came up with the “wrong findings”. Perhaps this weighs heavily on the minds of academics thinking of studying autism.
Robert Kennedy Jr Announces
This leads us to the announcement last week by Robert Kennedy Jr that the president-elect Mr Trump invited him to chair a committee on vaccine safety. Mr. Kennedy is a known friend of the “anti-vaccination” movement, and a proponent of “vaccine safety” . This announcement was not taken lightly by Big Pharma promptly firing “warning shots across the bow”, sending a message to Team Trump that this is out of bounds and they are not happy. In other words, all hell broke loose in the mainstream media. The sheer volume and energy of the attack by mainstream media was mind boggling. Finally, after about a week or so, it was revealed that the whole thing was a big nothing, there was no invitation, merely a conversation about the idea.
Vaccination, Politics and Safety
If a health professional Injects a drug into a human, this procedure is governed by federal state and local regulations . For example, the patient must consent to the procedure, and the injected drug must have FDA approval. If the drug causes adverse effects as a result of negligence, then the patient has a right to sue the drug maker in court for damages. However for vaccinations, these same rules don’t apply. Some states are repealing vaccine exemptions making vaccination mandatory, forgetting about the requirement for patient consent.
Vaccine Makers Exempt from Liability
In 1986 the Congress passed the National Childhood Vaccine Injury Act making the drug makers exempt from liability for their vaccine product. Instead of suing the drug maker in state court, the aggrieved victim of a vaccine injury must take his or her case to the federal vaccine court. Any settlements paid out to the victims of vaccine injury are paid by the federal government, not by the vaccine makers.
According to Sharyl Attkisson, from 1998 to 2015 , over 15,916 claims have been filed in federal vaccine court. 4,121 were compensated, 9,904 were dismissed. The total amount paid to victims is approximately $3.1 billion.(4) The fact that over 3 billion dollars has been paid to victims of vaccine injury suggests there is more work to do if we want safe vaccines. In other words, there may be safety issues with certain vaccines that are not being fully addressed.
The Science is NOT Settled
All of these media attack article say the same thing: “The Science is settled. All vaccines are safe. There is no connection to autism,” This is all true as long as one realizes that the science they are all talking about is industry sponsored science. Researchers are paid to come up with the “correct ” findings for their study. There is a historical precedent called “tobacco science”. The tobacco industry claimed that “science has proven cigarettes are healthy and do not cause cancer.” We know other wise. The reality is the industry sponsored science is tainted, and independent researchers live in fear of reprisals for any breach of silence. This is not a free environment.
Vaccines Should Be Regulated Like Any Other Drug
I think there was a fundamental mistake made by Congress in removing liability from vaccine manufacturers in 1986. Vaccines should be treated and regulated same as any other drug. New vaccines should rise or fall with the marketplace and not be falsely subsidized by the federal government.
Some drugs are FDA approved and then later banned when problems are discovered. Same is true for some vaccines. By removing liability from the vaccine makers, they have no incentive to make vaccines safe. And without liability costs, the vaccines are now more profitable, creating more incentive to make more and more vaccine products, as we have seen over the years.
Some Vaccines Work, Others Are not Worth the Risks
Some drugs are quite effective with few side effects, while others are discarded because they don’t work so well, or they carry horrendous adverse effects . Same for vaccines. Some work. Some don’t and are either not approved or later banned. Examples are the live Sabine polio vaccine discontinued in the US in 2000 because the vaccine itself was causing VAPP, vaccine associated paralytic polio. The Swine flu vaccine was banned in 1976 because of increased Guillan Barre syndrome after vaccination. etc. In Sweden, whole cell pertussis vaccination was suspended in 1979, and was later replaced with a safer acellular Pertussis vaccine.(32-37). In Japan, DTP vaccination was banned in 1993 due to safety concerns.(31) A partial listing of discontinued vaccines can be seen here: Discontinued_Vaccines .(28-29)
The Bill Haast Story Immunity from Snake Venom
An example of vaccination that worked is the Bill Haast story. Suppose you worked in a serpentarium handling venomous snakes. Wouldn’t it be advantageous to have small periodic injections of snake venom so you will eventually be immune to it.? That is exactly what Bill Haast did. Bill Haast built up immunity by injecting himself every day for 60 years with venoms from 32 snake species. (27) This allowed him to survive 173 poisonous snake bites during his career as a snake handler. (27) However, just because it worked for Bill Haast, mandatory snake venom vaccination for all school children is obviously not a good idea.
What Will Trump Do Once In Office ?
Will the president elect Mr. Trump stick by his guns on this issue, or will he back down and fold? Exactly how this plays out is anyone’s guess. We will have to wait until after inauguration January 20, and then see what happens after Mr Trump actually takes office.
Articles with Related Interest:
The Failure of Global Polio Eradication
Which is Greater Threat Measles or Measles Vaccine ?
Do Vaccinations Cause Autism ?
Jeffrey Dach MD
Links and References
1) What REALLY Kills Us 11/11/2013 David Katz, M.D.
Feet, forks, and fingers are the master levers of medical destiny. Dr. Katz says:
“The actual, underlying “cause” of premature death in our country fully eight times in 10 comes down to bad use of our feet (lack of physical activity), our forks (poor dietary choices), and/or our fingers (holding cigarettes).”(1)
2) CDC Autism Spectrum Disorder (ASD) Data & Statistics Prevalence
About 1 in 68 children has been identified with autism spectrum disorder (ASD) according to estimates from CDC’s Autism and Developmental Disabilities Monitoring (ADDM) Network. [Read summary] [Read article]
3) Newschaffer, Craig J., and Laura Kresch Curran. “Autism: an emerging public health problem.” Public health reports 118.5 (2003): 393.
4) How Public Health Can Deliver Breakthroughs for the Autism Community
5) Govt Wipes Recent Vaccine Injury Data From Website by sattkisson on December 30, 2015. From 1998 to 2015 : over 15,916 claims have been filed in vaccine court. 4,121 were compensated, 9,904 were dismissed. The total amount paid to victims is approximately $3.1 billion.
5) What REALLY Kills Us
11/11/2013 11:59 am ET | Updated Jan 23, 2014
David Katz, M.D. Founder, True Health Initiative
6) Dr. David Katz is a former Director of Medical Studies in Public Health at the Yale School of Medicine,
David L. Katz MD, MPH, FACPM, FACP, FACLM is an internationally renowned authority on nutrition, weight control, and the prevention of chronic disease. He is also recognized internationally as an authority on evidence-based, integrative medicine.
He is an Associate Professor (adjunct) of Public Health Practice, and formerly the Director of Medical Studies in Public Health, at the Yale University School of Medicine. Dr. Katz directs Yale University’s Prevention Research Center which he co-founded in 1998. As director of this clinical research laboratory dedicated to chronic disease prevention, Katz has served as Principal Investigator for numerous community and clinical trials, and has acquired and managed well over $20 million in research funds.
Dr. Katz earned his BA from Dartmouth College (in 3 years), his MD from the Albert Einstein College of Medicine, and his MPH from the Yale University School of Public Health. He is board-certified in Internal Medicine, and Preventive Medicine/Public Health.
7) Trump team denies skeptic Robert F. Kennedy Jr. was asked to head vaccine commission
By Dan Merica, CNN Updated 6:17 PM ET, Tue January 10, 2017
https://thefederalist.com/2017/01/12/...
No, Anti-Vaxxer Robert Kennedy Jr. Won’t Be Trump’s ‘Vaccine Czar’
The media should have checked this out before reporting it as fact and even going so far as to call Robert F. Kennedy Jr. a ‘vaccine czar’ without any confirmed details.
8) Anti-Vaccine Activist Says Trump Wants Him to Lead Panel on Immunization Safety By MICHAEL D. SHEAR, MAGGIE HABERMAN and PAM BELLUCK JAN. 10, 2017
9) Why Donald Trump’s Choice of RFK Jr. as Vaccine Czar Is a Terrible Idea
Jeffrey Kluger Updated: Jan. 10, 2017 6:40 PM
10) What Could Trump Really Do to Vaccines?
Are the president-elect’s anti-vaccine tweets and meetings with leading anti-vaxxers a signal he’s going to change U.S. immunization policy? And does he really have the power to do so?
Brandy Zadrozny 01.13.17
11) Why Trump’s Meeting With RFK Jr. Has Scientists Worried by Tara Haelle January 12, 2017
12) Vaccine skeptic Robert Kennedy Jr. says Trump asked him to lead commission on ‘vaccine safety’
13) Robert F. Kennedy Jr., Newly Appointed Vaccine Chair, Has A Dangerously Anti-Science View
You can’t say you’re OK with vaccines but also spread conspiracy theories about their ingredients. 01/10/2017 06:20 pm ET | Updated 12 hours ago
14) Robert Kennedy Jr. warns of vaccine-linked ‘holocaust’ April 7, 2015 8:44 PM
15) January 10, 2017, 1:21 PM
Robert Kennedy Jr. says he will chair “vaccination safety” committee for Trump
16) Trump taps anti-vaccine activist to chair vaccine safety panel
By Brad Dixon 13 January 2017
17) By Will Rahn CBS News January 12, 2017, 6:00 AM
Commentary: The big Trump scandal this week wasn’t about Russia
18) Trump’s Dangerous Support for Conspiracies About Autism and Vaccines. By Michael Specter January 11, 2017
=========================================
19) Ann Pharmacother. 2011 Oct;45(10):1302-4. The vaccine-autism connection: a public health crisis caused by unethical medical practices and fraudulent science. Flaherty DK1.
In 1998, Dr. Andrew Wakefield, a British gastroenterologist, described a new autism phenotype called the regressive autism-enterocolitis syndrome triggered by environmental factors such as measles, mumps, and rubella (MMR) vaccination. The speculative vaccination-autism connection decreased parental confidence in public health vaccination programs and created a public health crisis in England and questions about vaccine safety in North America. After 10 years of controversy and investigation, Dr. Wakefield was found guilty of ethical, medical, and scientific misconduct in the publication of the autism paper. Additional studies showed that the data presented were fraudulent. The alleged autism-vaccine connection is, perhaps, the most damaging medical hoax of the last 100 years.
20) Rao, TS Sathyanarayana, and Chittaranjan Andrade. “The MMR vaccine and autism: Sensation, refutation, retraction, and fraud.” Indian journal of psychiatry 53.2 (2011): 95.
21) The Vaccine Autism Cover-up: How One Doctor’s Career was Destroyed for Telling the Truth By Brian Shilhavy
Editor, Health Impact News
22) New Published Study Verifies Andrew Wakefield’s Research on Autism – Again. Controversial Doctor and Autism Media Channel Director proven right MMR Vaccine Causes Autism & Inflammatory Bowel Disease
23) BuzzFeed on Trump’s Kennedy Appointment Features Age of Autism and JB Handley
24) Trump’s Would-Be Vaccine Commissioner Rallies Anti-Vaccine Groups
In an email to anti-vaccine activists, Robert F. Kennedy Jr. urged them to contact Trump, who was “getting massive blowback and waivering [sic].” Activists are “mobilized, energized, and extremely hopeful,” one individual said. posted on Jan. 11, 2017, Azeen Ghorayshi BuzzFeed News Reporter
25) Trump Moves To Challenge Vaccine Science
Robert F. Kennedy Jr., who published a controversial book about the preservatives in vaccines being dangerous for children, will chair a commission on vaccine safety. Scientists reject his views.
Originally posted on Jan. 10, 2017, at 1:37 p.m. Updated on Jan. 10, 2017, at 6:05 p.m. Azeen Ghorayshi
26) September 19, 2015 Dear Doctors that are “horrified” that Donald Trump and others claim that vaccines are linked to autism
You don’t know the research. It shows that they are.
27) Bill Haast, a Man Charmed by Snakes, Dies at 100
By DOUGLAS MARTINJUNE 17, 2011
Mr. Haast was bitten at least 173 times by poisonous snakes, about 20 times almost fatally. It was all in a day’s work for probably the best-known snake handler in the country, a scientist-cum-showman who made enough money from milking toxic goo from slithery serpents to buy a cherry-red Rolls-Royce convertible.
A secret of his success was the immunity he had built up by injecting himself every day for more than 60 years with a mix of venoms from 32 snake species. He suspected the inoculations might have explained his extraordinarily good health, but he was reluctant to make that claim, he said, until he reached 100.
28) Discontinued Vacccines discontinued_vaccines-1
Cervarix – an HPV vaccine that was discontinued in the US in 2016
Comvax – a Hib/Hepatitis B combination – discontinued in 2014
Tetanus toxoid – discontinued 2013
Tripedia – a DTaP vaccine – discontinued 2011
TriHIBit – a DTaP/Hib combination
JE-VAX – discontinued 2005
Attenuvax – measles vaccine
Mumpsvax – mumps vaccine
Meruvax II – rubella vaccine
M-R-Vax – measles and rubella combo
M-M-Vax – measles and mumps combo
Biavax II – rubella and mumps combo
Heptavax-B – the original hepatitis B vaccine
HIB-Vax – the original Hib vaccine
Plague vaccine
Poliovax
Dryvax – smallpox vaccine
Measles-Smallpox combination vaccine
Diptussis – a diphtheria/pertussis combination (1949-55)
Quadrigen – a DTP/Polio combination (1959-68)
Streptococcus vaccine (1952-88)
Serobacterin – a pertussis vaccine (1945-54)
Rocky mountain spotted fever vaccine (1942-78)
Typhus vaccine (1941-79)
smallpox vaccine (1917-1976)
30) President Trump ‘Vaccine Hero’ Published on January 13, 2017
31) Why Japan banned MMR vaccine by JENNY HOPE, Daily Mail
The triple jab was banned in Japan in 1993 after 1.8 million children had been given two types of MMR and a record number developed non-viral meningitis and other adverse reactions.
pertussis whooping cough
32) Klein, Nicola P. “Licensed pertussis vaccines in the United States: History and current state.” Human vaccines & immunotherapeutics 10.9 (2014): 2684-2690. In the 1970s and 1980s, Japan suspended their pertussis vaccination program because of safety concerns.28 Sato Y, Kimura M, Fukumi H. Development of a pertussis component vaccine in Japan. Lancet 1984; 1:122-6; PMID:6140441;
In Sweden, effectiveness concerns led to a suspension of Sweden’s pertussis vaccination program.Other countries such as the
United Kingdom, Italy, Ireland, Australia, West Germany and Russia saw substantially reduced pertussis vaccine acceptance within their populations. In the US by the mid-1980s, lawsuits related to vaccine safety led several manufacturers to withdraw their DTP vaccines and paved the way to the US National Childhood Vaccine Injury Act in 1986. This act provides funds to compensate for adverse events following immunization. Faced with such widespread apprehension surrounding DTP safety, great efforts were made to develop acellular pertussis vaccines.
33) ROMANUS, VICTORIA, RAGNAR JONSELL, and SETH-OLOF BERGQUIST. “Pertussis in Sweden after the cessation of general immunization in 1979.” The Pediatric infectious disease journal 6.4 (1987): 364-371.
34) Vaccine. 2003 May 16;21(17-18):2015-21.
Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine.
Olin P1, Gustafsson L, Barreto L, Hessel L, Mast TC, Rie AV, Bogaerts H, Storsaeter J.
Acellular pertussis vaccines were introduced nation-wide in Sweden in 1996, 17 years after the withdrawal of whole-cell pertussis vaccine from the childhood immunisation schedule. We report national data on age specific incidence of culture-confirmed Bordetella pertussis for 1986-2000, and clinical follow-up for 3 years (October 1997-September 2000) in children born in 1996-2000 and from children born in 1993-1994 who had participated in a trial of pertussis vaccines. The annual incidence of culture-confirmed B. pertussis was 89-150 per 100,000 before introduction of acellular pertussis vaccines and has dropped to 17-26 per 100,000. The data suggest that unimmunised infants and children who have received only one dose of pertussis vaccine were provided some protection. The decline is most obvious from the second dose onwards and remained stable for 4-5 years after the third dose in the absence of any booster dose. The first signs of waning immunity were observed at 6-7 years of age in the trial cohort. The short-term benefits reflect high vaccination coverage and high initial efficacy. The full impact of the acellular pertussis vaccination programme in infants remains to be established.
35) Klein, Nicola P., et al. “Comparative effectiveness of acellular versus whole-cell pertussis vaccines in teenagers.” Pediatrics 131.6 (2013): e1716-e1722.
BACKGROUND: During the 1990s, the United States switched from combined diphtheria, tetanus toxoids, whole-cell pertussis (DTwP) vaccines to combined acellular pertussis (DTaP) vaccines because of safety concerns. After a 2010–2011 pertussis outbreak, we sought to evaluate whether disease risk in 10 to 17 year olds differed between those who previously received DTwP from those who received DTaP.
36) Plotkin, Stanley A. “The pertussis problem.” Clinical infectious diseases (2013): cit934.
37) Adv Exp Med Biol. 2016;934:77-82. doi: 10.1007/5584_2016_21.
Pertussis: History of the Disease and Current Prevention Failure.
Kuchar E1, Karlikowska-Skwarnik M2, Han S3, Nitsch-Osuch A4.
Pertussis or whooping cough has been given many names over the centuries. It was first recognized in the Middle Ages and since then various epidemics have been described. Jules Bordet and Octave Gengou isolated Bordetella pertussis, a causative agent for whooping cough, in Paris more than 100 years ago, which created an excellent opportunity to invent a vaccine. In 1914 the whole-cell pertussis vaccine was invented, then in the 1940s it was combined with tetanus and diphtheria toxoids to become DTP and it became widely available. A successive decrease in the incidence of the disease has since been observed. The vaccine has been about 80 % effective in preventing serious disease and death from pertussis. The disadvantage is that the vaccine offers protection for 5-10 years after the last dose of the full vaccination course. The second issue is the question of how to prevent side effects of the whole-cell vaccine. In the 1990s, the acellular vaccine was introduced in the US and gradually replaced the whole-cell vaccine. About 10 years later, a possible failure with the new vaccine has been observed, that is a lack of long-term protection. Nowadays, both vaccines are used, with the acellular vaccine being vastly predominant in most developed countries. Pertussis incidence has increased since the 1980s, but new prevention strategies include booster doses for specific age groups.
Jeffrey Dach MD
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December 30, 2016
Iodine Crisis by Lynne Farrow Book Review
The Iodine Crisis: What You Don’t Know About Iodine Can Wreck Your Life by Lynne FarrowBook Review by Jeffrey Dach MD
If you are a woman diagnosed with fibrocystic breast disease or breast cancer, you need to read this book. If you are a woman who undergoes repeated breast biopsies or breast cyst aspirations, then you need to read this book. If you are a breast cancer survivor, then you need to read this book.
As an interventional radiologist for 30 years, my job was to read the mammograms and perform the procedures, the breast biopsies and needle aspirations. Some women had multiple cysts and nodules and returned to the department every year for repeat aspirations and biopsy procedures. They would always corner me in the reading room and ask, “Doctor, what can I do to make these cysts and nodules in my breast go away”? And for 30 years I would throw up my hands and say “we just don’t know”.. .
After I retired from radiology and returned to clinical medicine in 2004, I attended medical meetings and listened to David Brownstein MD and George Flechas MD speaking about the health benefits of Iodine supplementation.
Iodine is the answer to fibrocystic breast disease. Iodine is the answer for breast cancer prevention. Iodine is the answer I should have been giving to all the women over the years I worked in the hospital X-ray department, but didn’t. So I am making up for it now. We routinely test for Iodine level, and give Iodine supplements to every woman in my clinic. I consider this extremely important. Left Image Book Cover The Iodine Crisis: What You Don’t Know About Iodine Can Wreck Your Life
by Lynne Farrow
Lynne Farrow is a gifted writer and her book chronicles in exquisite detail her personal story and discovery of Iodine and her journey as an Iodine advocate. Her book describes how Iodine was used for decades as a natural medicine, and then virtually eliminated from mainstream medicine and our food in the 1960’s by bad research. You will find it difficult to put this book down. There is much more of the story to be told, so go ahead and get yourself a copy and read it over and over again. Share it with your friend, and go online to Lynne Farrow’s BreastCancerChoices.org and the Iodine Group.to spread the word and spark a new revolution in the use of Iodine . You can share with Lynne Farrow her mission to restore Iodine back to Medicine and kick off a grass roots campaign to prevent breast cancer.
Click Here for WHO Iodine Testing Guidelines: Iodine Guidlines: WHO_Urinary Excretion 2013 World Health Organization
Click Here to buy Iodoral on Amazon.
Articles with related interest:
Breast Cancer Prevention with Iodine Supplementation
Iodine Treats Breast Cancer, Overwhelming Evidence
Other books on this topic:
Iodine: Why you need it, Why you can’t live without it by David Brownstein MD
Link to this page http://wp.me/p3gFbV-4iH
Jeffrey Dach MD
7450 Griffin Road Suite 190
Davie, Florida 33314
954-792-4663
http://www.drdach.com/
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