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Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime by Aubrey de Grey
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“I have been aware for many years that most people do not think about aging in the same way that they think about cancer, or diabetes, or heart disease. They are strongly in favor of the absolute elimination of such diseases as soon as possible, but the idea of eliminating aging—maintaining truly youthful physical and mental function indefinitely—evokes an avalanche of fears and reservations. Yet, in the sense that matters most, aging is just like smoking: It’s really bad for you.”
Aubrey de Grey, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
“P1 - Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing.

For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by.

From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability."

"David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale.

When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives."

"I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000

So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first.

This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely.

Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.”
Aubrey De Grey, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
“P4 - The good news is that there is at least one emerging technology out there that is looking mighty promising right now: it’s called helium persufflation, and I’m currently orchestrating the funding of the most critical research into making it work.

Over the course of 2023 LEV Foundation has coordinated an effort, conceived by Martin O’Dea and Dr. Aubrey de Grey, to lay to rest the lamentable opinion that aging, along with the disease and death it brings, is inevitable - and by extension, that attempts to combat it are unworthy of serious recognition or support.

We assert instead that an immediate expansion of work to extend healthy lifespans is not only credible, but indeed crucial to the quality of our collective future.

In collaboration with primary author Professor Brian Kennedy, with input and enthusiastic endorsement from iconic researchers and leaders across the field of longevity medicine and allied fields, we are now able to publish the result of that effort - the Dublin Longevity Declaration: Consensus Recommendation to Immediately Expand Research on Extending Healthy Human Lifespans.

Whatever your background, we encourage everyone who reads the Declaration and agrees with its message to add your signature, and encourage your friends and colleagues to consider doing the same: www. dublinlongevitydeclaration. org

More on all of this here: www. quora. com/profile/Aubrey-de-Grey/answers”
Aubrey de Grey, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
“Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing.

For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by.

From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability."

"David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale.

When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives."

"I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000

So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first.

This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely.

Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.”
Aubrey De Grey, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime