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Chemistry: A Very Short Introduction Chemistry: A Very Short Introduction by Peter Atkins
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“Whereas chemistry reaches down into physics for its explanations (and through physics further down into mathematics for its quantitative formulation), it reaches upwards into biology for many of its most extraordinary applications. That”
Peter Atkins, What is Chemistry?: A Very Short Introduction
“Perhaps nowhere is modern chemistry more important than in the development of new drugs to fight disease, ameliorate pain, and enhance the experience of life. Genomics, the identification of genes and their complex interplay in governing the production of proteins, is central to current and future advances in pharmacogenomics, the study of how genetic information modifies an individual's response to drugs and offering the prospect of personalized medicine, where a cocktail of drugs is tailored to an individual's genetic composition.

Even more elaborate than genomics is proteomics, the study of an organism's entire complement of proteins, the entities that lie at the workface of life and where most drugs act. Here computational chemistry is in essential alliance with medical chemistry, for if a protein implicated in a disease can be identified, and it is desired to terminate its action, then computer modelling of possible molecules that can invade and block its active site is the first step in rational drug discovery. This too is another route to the efficiencies and effectiveness of personalized medicine.”
Peter Atkins, Chemistry: A Very Short Introduction
“When we encounter tiny groups of atoms, interesting questions and special rules come into play. Take water, for instance: what is the smallest possible ice cube? It has been discovered that you need at least 275 water molecules in a cluster before it can show ice-like properties, with about 475 molecules before it becomes truly ice. That is a cube with about eight H2O molecules along each edge. The importance of this kind of knowledge is that it helps us model the process of cloud formation in the atmosphere as well as understand how liquids freeze.”
Peter Atkins, Chemistry: A Very Short Introduction
“One of the most powerful tools for discovering structure is ‘X-ray diffraction’ or, because it is always applied to crystals of the substance of interest, ‘X-ray crystallography’. The technique has been a gushing fountain of Nobel prizes, starting with Wilhelm Röntgen’s discovery of X-rays (awarded in 1901, the first physics prize), then William and his son Laurence Bragg in 1915, Peter Debye in 1936, and continuing with Dorothy Hodgkin (1964), and culminating with Maurice Wilkins (but not Rosalind Franklin) in 1962, which provided the foundation of James Watson’s and Francis Crick’s formulation of the double-helix structure of DNA, with all its huge implications for understanding inheritance, tackling disease, and capturing criminals (a prize shared with Wilkins in 1962). If there is one technique that is responsible for blending biology into chemistry, then this is it. Another striking feature of this list is that the prize has been awarded in all three scientific categories: chemistry, physics, and physiology and medicine, such is the range of the technique and the illumination it has brought.”
Peter Atkins, Chemistry: A Very Short Introduction
“Metal atoms are bound together by metallic bonding. That is not just a tautology. The clue to its nature is the fact that all the metals lie towards the left-hand side of the Periodic Table where, as we have seen, the atoms of the elements have only a few electrons in their outermost cloud layers and which are readily lost. To envisage metallic bonding, think of all these outermost electrons as slipping off the parent atom and congregating in a sea that pervades the whole slab of atoms. The cations that are left behind lie in this sea and interact favourably with it. As a result, all the cations are bound together in a solid mass. That mass is malleable because, like an actual sea, it can respond readily to a shift in the positions of the cations in the mass when they are struck by a hammer. The electrons also allow the metal to be drawn out into a wire, by responding immediately to the relocation of the cations. As the electrons in the sea are not pinned down to particular atoms, they are mobile and can migrate through the solid in response to an electric field. Metals are lustrous because the electrons of the sea can respond to the shaking caused by the electric field of an incident ray of light, and that oscillation of the sea in turn generates light that we perceive as reflection. When we gaze into the metal coating of a mirror, we are watching the waves in the metal’s electron sea.”
Peter Atkins, Chemistry: A Very Short Introduction
“Through chemistry we can unravel and comprehend the once inscrutable mysteries of the natural world. We can understand the green of a leaf and the red of a rose, the fragrance of a herb and new-mown hay. We can understand, in a halting but increasing way, the intricate and complex reticulation of processes in the natural world that constitute the awesome and multifaceted property we know as life. We are beginning, even more haltingly, to understand the chemical processes in our brains that enable us to perceive, wonder, and understand.”
Peter Atkins, Chemistry: A Very Short Introduction
“While we are in this embarrassingly negative corner of chemistry, I cannot avoid that other great pointed finger, the one directed at the environmental damage laid at the subject’s door, or at least at its drains. It is impossible to deny that the unwanted effluent of the chemical plant has wrought ecological havoc. Ever since Perkin’s factories turned the nearby canals red, green, and yellow according to the manufacturing priorities of the day, mankind’s aspiration for its own betterment has been at an environmental cost. In fact, the green shoots of environmental pollution, if that is not too ironical a term, can be traced back to the Greeks and Romans, for analysis of ice cores laid down in those eras show traces of the consequences of metal working.

The way forward is either legal or chemical. The legal constrains by the prospect of punishment; the chemical avoids by elimination at source. The latter, always the better mode of action, depends on developments of chemistry itself and has inspired the politico-environmento-chemical movement of green chemistry. In broad terms, green chemistry aims to minimize the impact of chemical manufacturing processes on the environment by strict guidelines about the use of materials and the elimination of waste.”
Peter Atkins, Chemistry: A Very Short Introduction
“The crucial consideration, however, is where reliable solutions to the world’s problems will come from if it is not further development of chemistry. Chemistry holds the key to the enhancement of almost every aspect of our daily lives, from the cradle to the grave and all points in between. It has provided the material foundation of all our comforts, not only in health but in illness too, and there is no reason to suppose that it has reached its zenith. It contributes to our communications, both virtual and physical, for it provides the materials along which our electrons and photons travel in the complex network of patterns and interactions that result in computation. Moreover, it develops our fuels, rendering them more efficiently combustible and through catalysis minimizing their noxious products, and helps in the migration from fossil fuels to renewable sources, such as in the development of photovoltaic substances. Chemistry is the only solution to the problems it causes in the environment, be it in earth, air, or water.”
Peter Atkins, Chemistry: A Very Short Introduction
“Then there is the dark side of chemistry. It would be inappropriate in this account of chemistry’s great achievements for no mention to be made of its ability to enhance humanity’s ability to damage and kill, for those achievements have come at a cost, in some cases to human life, in others to the environment.”
Peter Atkins, Chemistry: A Very Short Introduction
“The shift of chemistry’s attention to the processes of life has come at a time when the traditional branches of chemistry—organic, inorganic, and physical—have reached a stage of considerable maturity and are ready to tackle the awesomely complex network of processes going on inside organisms: human bodies in particular. The approach to the treatment, more importantly the prevention, of disease has been put on a rational basis by the discoveries that chemists continue to make. If you plan to enter this field, then genomics and proteomics will turn out to be of crucial importance to your work. This is truly a region of chemistry where you can feel confident about standing on the shoulders of the giants who have preceded you and know that you are attacking disease at its roots.”
Peter Atkins, Chemistry: A Very Short Introduction
“Closely allied with the contribution of chemists to the alleviation of disease is their involvement at a molecular level. Biology became chemistry half a century ago when the structure of DNA was discovered (in 1953). Molecular biology, which in large measure has sprung from that discovery, is chemistry applied to the functioning of organisms. Chemists, often disguised as molecular biologists, have opened the door to understanding life and its principal characteristic, inheritance, at a most fundamental level, and have thereby opened up great regions of the molecular world to rational investigation. They have also transformed forensic medicine, brought criminals to justice, and transformed anthropology.”
Peter Atkins, Chemistry: A Very Short Introduction
“Petroleum is, of course, an extraordinarily convenient source of energy, as it can be transported easily, even in weight-sensitive aircraft. Chemists have long contributed to the refinement of the raw material squeezed and pumped from the ground. They have developed processes and catalysts that have taken the molecules provided by Nature and used them to cut the molecules into more volatile fragments and reshape them so that they burn more efficiently. But burning Nature’s underground bounty might by future generations be seen as the wanton destruction of an invaluable resource, akin to species extinction. It is also finite, and although economically viable new sources of petroleum are constantly, for the time being at least, being discovered, it is proving hazardous and increasingly expensive to extract it. We have to accept that although an empty Earth is decades off, one day it will arrive and needs to be anticipated.”
Peter Atkins, Chemistry: A Very Short Introduction
“Whereas chemistry reaches down into physics for its explanations (and through physics further down into mathematics for its quantitative formulation), it reaches upwards into biology for many of its most extraordinary applications. That should not be surprising, for biology is merely an elaboration of chemistry. Before biologists explode in indignation at that remark, which might seem akin to claiming that sociology is an elaboration of particle physics, let me be precise. Organisms are built from atoms and molecules, and those structures are explained by chemistry. Organisms function, that is, are alive, by virtue of the complex network of reactions taking place within them, and those reactions are explained by chemistry. Organisms reproduce by making use of molecular structures and reactions, which are both a part of chemistry. Organisms respond to their environment, such as through olfaction and vision, by changes in molecular structure, and thus those responses—all our five or so senses—are elaborations of chemistry. Even that hypermacroscopic phenomenon, evolution and the origin of species, can be regarded as an elaborate working out of the consequences of the Second Law of thermodynamics, and is thus an aspect of chemistry. Some organisms, I have in mind principally human beings, cogitate on the nature of the world, and the mental processes that underlie Chemistry and are manifest as these cogitations are due to elaborate networks of chemical reactions. Thus, biology is indeed an elaboration of chemistry. I shall not press the view, whatever I actually think, that all matters of interest to biologists, such as animal behaviour in general, are also merely elaborated chemistry, but confine myself to the assertion that all the structures, responses, and processes of organisms are chemical. Chemistry thus pervades biology, and has contributed immeasurably to our understanding of organisms.”
Peter Atkins, Chemistry: A Very Short Introduction
“I want to share with you the thought that chemistry provides the infrastructure of the modern world. There is hardly an item of everyday life that is not furnished by it or based on the materials it has created. Take away chemistry and its functional arm the chemical industry and you take away the metals and other materials of construction, the semiconductors of computation and communication, the fuels of heating, power generation, and transport, the fabrics of clothing and furnishings, and the artificial pigments of our blazingly colourful world. Take away its contributions to agriculture and you let people die, for the industry provides the fertilizers and pesticides that enable dwindling lands to support rising populations. Take away its pharmaceutical wing and you allow pain through the elimination of anaesthetics and deny people the prospect of recovery by the elimination of medicines. Imagine a world where there are no products of chemistry (including pure water): you are back before the Bronze Age, into the Stone Age: no metals, no fuels except wood, no fabrics except pelts, no medicines except herbs, no methods of computation except with your fingers, and very little food.”
Peter Atkins, Chemistry: A Very Short Introduction
“That collapse gives an impulse to what we think of as the vacuum that surrounds the atom, and the impulse generates a pulse of light, a photon. The colour of the photon depends on the energy released in the collapse, with high-energy collapse giving a pulse of ultraviolet radiation and lower energy pulses giving visible light.”
Peter Atkins, What is Chemistry?: A Very Short Introduction