“At low speeds, the effort is primarily aerobic (meaning “with oxygen”), since oxygen is required for the most efficient conversion of stored food energy into a form your muscles can use. Your VO2max reflects your aerobic limits. At higher speeds, your legs demand energy at a rate that aerobic processes can’t match, so you have to draw on fast-burning anaerobic (“without oxygen”) energy sources. The problem, as Hopkins and Fletcher had shown in 1907, is that muscles contracting without oxygen generate lactic acid. Your muscles’ ability to tolerate high levels of lactic acid—what we would now call anaerobic capacity—is the other key determinant of endurance, Hill concluded, particularly in events lasting less than about ten minutes.”