A Goodreads user asked Charles Stross:

Having picked up the free addition of The Bloodline Feud (Thanks Tor books!). I've moved onto The Traders War. I notice the outcome for Native Americans is the same in all 3 timelines. Did you ever consider a different fate? I recommend "1491" by Charles C Mann as an eye-opening account of the American continent before the Europeans arrival.

Charles Stross 1491 came out some time after I started writing the series (published in 2005; I wrote the first two books of this series — which ended up as "The Bloodline Feud" in 2002 and they were published by 2004). As you might have noticed, I'm not American (I'm an interested alien) and I got some things wrong. However, I'm going with the likely outcome of contact between previously isolated continents being epidemiologically similar because the zoonoses that crossed into human populations and became endemic (e.g. smallpox, measles, mumps, tuberculosis) all did so in Europe/Asia/Africa long before these time lines diverged, and apparently didn't do so in the Americas, resulting in a human population with no herd immunity: see "Guns Germs and Steel" (which was the new hotness at the time I was writing).

I'll also note that in time line one, the world of the Gruinmarkt, the "white settlers" haven't made it into the continental interior, and on the west coast, the Chinese haven't made it past the California central valley: the interior, while underdescribed, is dominated by native American polities.

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