Harrison's Principles of Internal Medicine Quotes

“Yet skill in the most sophisticated applications of laboratory technology and in the use of the latest therapeutic modality alone does not make a good physician. When a patient poses challenging clinical problems, an effective physician must be able to identify the crucial elements in a complex history and physical examination; order the appropriate laboratory, imaging, and diagnostic tests; and extract the key results from densely populated computer screens to determine whether to treat or to “watch.” As the number of tests increases, so does the likelihood that some incidental finding, completely unrelated to the clinical problem at hand, will be uncovered. Deciding whether a clinical clue is worth pursuing or should be dismissed as a “red herring” and weighing whether a proposed test, preventive measure, or treatment entails a greater risk than the disease itself are essential judgments that a skilled clinician must make many times each day. This combination of medical knowledge, intuition, experience, and judgment defines the art of medicine, which is as necessary to the practice of medicine as is a sound scientific base.”
― J. Larry Jameson, Harrison's Principles of Internal Medicine

“At least 90% of all abdominal aortic aneurysms >4.0 cm are related to atherosclerotic disease,”
― Dennis L. Kasper, Harrison's Principles of Internal Medicine, Volumes 1 & 2

“pulmonary, cardiac, or neuromuscular condition and worsening dyspnea, the initial focus of the evaluation will usually address determining whether the known condition has progressed or whether a new process has developed that is causing dyspnea. For patients without a prior known potential cause of dyspnea, the initial evaluation will focus on determining an underlying etiology. Determining the underlying cause, if possible, is extremely important, as the treatment may vary dramatically based upon the predisposing condition. An initial history and physical examination remain fundamental to the evaluation followed by initial diagnostic testing as indicated that might prompt subspecialty referral (e.g., pulmonary, cardiology, neurology, sleep, and/ or specialized dyspnea clinic) if the cause of dyspnea remains elusive (Fig. 33-2). As many as two-thirds of patients will require diagnostic testing beyond the initial clinical presentation.”
― J. Larry Jameson, Harrison's Principles of Internal Medicine

“Single pulse transcranial magnetic stimulation (sTMS) is FDA-approved for the acute treatment of migraine. Two pulses can be applied at the onset of an attack and this can be repeated. The use of sTMS is safe where there is no cranial metal implant, and offers an option to patients seeking non-pharmaceutical approaches to treatment. Similarly, a noninvasive vagus nerve stimulator (nVNS) is FDA-approved for the treatment of migraine attacks in adults. One to two 120-second doses may be applied for attack”
― J Larry Jameson, Harrison's Principles of Internal Medicine

“Suboccipital decompression is recommended in patients with cerebellar infarcts who demonstrate neurological deterioration and should be performed before significant brainstem compression occurs.”
― J Larry Jameson, Harrison's Principles of Internal Medicine

“Combined analysis of three randomized European trials of hemicraniectomy (craniotomy and temporary removal of part of the skull) shows that hemicraniectomy reduces mortality by 50%, and the clinical outcomes of survivors are significantly improved. Older patients (age >60 years) benefit less, but still significantly. The size of the diffusion-weighted imaging volume of brain infarction during the acute stroke is a predictor of deterioration requiring hemicraniectomy.”
― J Larry Jameson, Harrison's Principles of Internal Medicine