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Lifespan: Why We Age—and Why We Don't Have To Lifespan: Why We Age—and Why We Don't Have To by David A. Sinclair
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“Aging, quite simply, is a loss of information.”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
“There isn’t much debate on the downsides of consumption of animal protein. Study after study has demonstrated that heavily animal-based diets are associated with high cardiovascular mortality and cancer risk.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Why would we choose to focus on problems that impact small groups of people if we could address the problem that impacts everyone—especially if, in doing so, we could significantly impact all those other, smaller problems?”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“The first principle is that you must not fool yourself—and you are the easiest person to fool.” R. P. Feynman,”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Thanks to an increasingly sedentary lifestyle and the abundance of sugars and carbohydrates on every supermarket shelf around the globe, high blood sugar is causing the premature deaths of 3.8 million people a year.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“a few years ago, researchers noticed a curious phenomenon: people taking metformin were living notably healthier lives—independent, it seemed, of its effect on diabetes.16 In”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Because as it turns out, exposing your body to less-than-comfortable temperatures is another very effective way to turn on your longevity genes.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Royal Society of London for Improving Natural Knowledge. More simply known as the Royal Society, the world’s oldest national scientific organization was established in 1660 to promote and disseminate “new science” by big thinkers of the day such as Sir Francis Bacon, the Enlightenment’s promulgator of “the prolongation of life.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“We’d die quite quickly without amino acids, the organic compounds that serve as the building blocks for every protein in the human body. Without them—and in particular the nine essential amino acids that our bodies cannot make on their own—our cells can’t assemble the life-giving enzymes needed for life.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“I believe that aging is a disease. I believe it is treatable. I believe we can treat it within our lifetimes. And in doing so, I believe, everything we know about human health will be fundamentally changed.”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
“As a species, we are living much longer than ever. But not much better. Not at all. Over the past century we have gained additional years, but not additional life—not life worth living anyway.5”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
“In my mind, there are few sins so egregious as extending life without health. This is important. It does not matter if we can extend lifespans if we cannot extend healthspans to an equal extent. And so if we’re going to do the former, we have an absolute moral obligation to do the latter.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Indeed, we know more about the health of our cars than we know about our own health. That’s farcical. And it’s about to change.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“As cloning beautifully proves, our cells retain their youthful digital information even when we are old. To become young again, we just need to find some polish to remove the scratches.”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
“Separating aging from disease obfuscates a truth about how we reach the ends of our lives: though it’s certainly important to know why someone fell from a cliff, it’s equally important to know what brought that person to the precipice in the first place. Aging brings us to the precipice. Give any of us 100 years or so, and it brings us all there. In”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“the evidence is irrefutable: if you believe climate change is a threat, you can’t say that GMOs are, because the evidence that GMOs are safe is stronger than the evidence that climate change is occurring.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“We can’t prevent all DNA damage—and we wouldn’t want to because it’s essential for the function of the immune system and even for consolidating our memories57—but we do want to prevent extra damage. And there’s a lot of extra damage to be had out there. Cigarettes, for starters. There aren’t many legal vices out there that are worse for your epigenome than the deadly concoction of thousands of chemicals smokers put into their bodies every day. There’s a reason why smokers seem to age faster: they do age faster. The DNA damage that results from smoking keeps the DNA repair crews working overtime, and likely the result is the epigenetic instability that causes aging. And although I’m not likely to be the first person you’ll hear this from, it nonetheless bears repeating: smoking is not a private, victimless activity. The levels of DNA-damaging aromatic amines in cigarette smoke are about fifty to sixty times as high in secondhand as in firsthand smoke.58 If you do smoke, it is worth trying to quit.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Like rapamycin, metformin mimics aspects of calorie restriction. But instead of inhibiting TOR, it limits the metabolic reactions in mitochondria, slowing down the process by which our cellular powerhouses convert macronutrients into energy.20 The result is the activation of AMPK, an enzyme known for its ability to respond to low energy levels and restore the function of mitochondria. It also activates SIRT1, one of my lab’s favorite proteins. Among other beneficial effects, metformin inhibits cancer cell metabolism, increases mitochondrial activity, and removes misfolded proteins.21”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Today, I can read an entire human genome of 25,000 genes in a few days for less than a hundred dollars on a candy bar–sized DNA sequencer called a MinION that I plug into my laptop. And that’s for a fairly complete readout of a human genome, plus the DNA methyl marks that tell you your biological age.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“That’s what people have been doing for centuries—without even knowing it—in centenarian-heavy places such as Okinawa, Japan; Nicoya, Costa Rica; and Sardinia, Italy. These are, you might recognize, some of the places the writer Dan Buettner introduced to the world as so-called Blue Zones starting in the mid-2000s. Since that time, the primary focus for those seeking to apply lessons from these and other longevity hot spots has been on what Blue Zone residents eat. Ultimately this resulted in the distillation of “longevity diets” that are based on the commonalities in the foods eaten in places where there are lots of centenarians. And overwhelmingly that advice comes down to eating more vegetables, legumes, and whole grains, while consuming less meat, dairy products, and sugar.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Using your nondominant hand, write your name, address, and phone number while circling your opposite foot counterclockwise.”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
“But consider this: though smoking increases the risk of getting cancer fivefold, being 50 years old increases your cancer risk a hundredfold. By the age of 70, it is a thousandfold”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“And because aging isn’t a disease by the commonly accepted definition, it doesn’t fit nicely into the system we’ve built for funding medical research, drug development, and the reimbursement of medical costs by insurance companies. Words matter. Definitions matter.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“There is great reason for hope on the not-so-distant horizon, but those battling against the ravages of aging right now must do so in a world in which most doctors have never even thought about why we age, let alone how to treat aging.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“I take 1 gram (1,000 mg) of NMN every morning, along with 1 gram of resveratrol (shaken into my homemade yogurt) and 1 gram of metformin.7 • I take a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Broken DNA causes genome instability, I wrote, which distracts the Sir2 protein, which changes the epigenome, causing the cells to lose their identity and become sterile while they fixed the damage. Those were the analog scratches on the digital DVDs. Epigenetic changes cause aging.”
David Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“Sirtuins instruct the histone spooling proteins to bind up DNA tightly, while they leave other regions to flail around. In this way, some genes stay silent, while others can be accessed by DNA-binding transcription factors that turn genes on.12 Accessible genes are said to be in “euchromatin,” while silent genes are in “heterochromatin.” By removing chemical tags on histones, sirtuins help prevent transcription factors from binding to genes, converting euchromatin into heterochromatin.”
David Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“ANTAGONISTIC PLEIOTROPY: A theory proposed by George C. Williams as an evolutionary explanation for aging: a gene that reduces lifespan in late life can be selected for if its early benefits outweigh its late costs. An example of this is the survival circuit.”
David A. Sinclair, Lifespan: Why We Age—and Why We Don't Have To
“But now I am six, I’m as clever as clever. So I think I’ll be six now for ever and ever.”
David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To

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