The Vaccine Book Quotes

“Most current licensed antiviral vaccines utilize live-attenuated or whole-inactivated viruses, although there are now a few examples of effective virus-like particle (VLP) vaccines. In the setting of a new pandemic viral threat and without the advantage of a preexisting understanding of its pathogenesis, growth or attenuating features, it would be difficult to quickly develop traditional live-attenuated or whole-inactivated vaccine approaches due to uncertainty about the safety of attenuating mutations or the production of replication-competent virus in bulk”
― Barry R. Bloom, The Vaccine Book