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Super Agers: An Evidence-Based Approach to Longevity Super Agers: An Evidence-Based Approach to Longevity by Eric Topol
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“In 2024, Consumer Reports’ cover article “How to Eat Less Plastic” ranked eighty-five specific food products (Annie’s organic cheesy ravioli came out on top with 53,579 ng total phthalates per serving, followed by Wendy’s crispy chicken nuggets at 33,980 ng). Strategies suggested to limit exposure included avoiding plastic food storage containers, fast foods, and high-fat foods (higher level of plasticizers that are fat soluble); using water bottles made of glass or steel and kitchen tools made of wood or steel; and limiting use of vinyl. Despite the urgent need to address the ever-growing plastic crisis, little has been done.”
Eric Topol, Super Agers: An Evidence-Based Approach to Longevity
“First, these foods and beverages contain additives and industrial ingredients. It’s a long list, but here are some of the chemicals you should avoid or limit: coloring agents, sweeteners such as maltodextrin, high-fructose corn syrup, fruit juice concentrates, dextrose, lactose, artificial sweeteners, hydrogenated oils, palm oil, calcium propionate, soy protein isolate, modified starches such as maltitol, calcium caseinate, hydrolyzed beef gelatin, and emulsifiers such as soy lecithin, xanthan gum, guar gum, and diacetyl tartaric acid esters of mono- and diglycerides.”
Eric Topol, Super Agers: An Evidence-Based Approach to Longevity
“The reversal of scarring (fibrosis) that occurs in many organs, previously considered as irrevocable, is being actively pursued in clinical trials with engineered T cells, known as chimeric antigen receptor (CAR-T) treatment, and new drugs, one of which was discovered using generative AI. CAR-T directed against fibrosis was used in mice to restore heart function. It was also used to achieve long-term remission of asthma and in the experimental model of multiple sclerosis to deplete a specific type of T cell population that attacks the body’s cells. This groundbreaking work is not just in animal models: a single shot of engineered T cells has achieved remissions, without the need for immunosuppression therapy, in patients with lupus and other autoimmune conditions.”
Eric Topol, Super Agers: An Evidence-Based Approach to Longevity
“Getting your polygenic risk score should not be expensive or difficult. The data can be derived from a gene chip (array) used by companies like 23andMe or AncestryDNA or”
Eric Topol, Super Agers: An Evidence-Based Approach to Longevity