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The Dark Side of Statins: Plus: The Wonder of Cholesterol The Dark Side of Statins: Plus: The Wonder of Cholesterol by Duane Graveline
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“Mechanism of Statin Drug Benefit Chapter Summary and Key Points. ·       I support the idea of statin use for high risk people, but at non-cholesterol lowering doses (low dose). · Any cardiovascular risk benefit from statins has no relationship to cholesterol reduction. ·       In addition to blockading cholesterol production, dolichols, CoQ10, selenoproteins and Rho are equally diminished by the effect of statins. · Like aspirin, statins reduce the production of the blood clotting agent thromboxane. ·       Blood levels of hs-CRP (high sensitivity C-reactive protein) — an inflammatory marker — are also reduced by statins. ·       Aspirin has shown benefit in both primary and secondary prevention of heart attacks and strokes. · Ora Shovman concluded that inflammation was the cause of atherosclerosis. · Statins show cardiovascular benefits for their anti-inflammatory effect.
· Even at a very low dose of a statin, inflammation is suppressed substantially. ·       Studies are needed to see whether statin sensitive people can tolerate low dose statins without the often debilitating side effects from higher doses.”
Duane Graveline, The Dark Side of Statins: Plus: The Wonder of Cholesterol