Deep Brain Stimulation Management Quotes

“In Parkinson's disease (PD), the results of dopamine deficiency include increased neuronal activity in the subthalamic nucleus (STN) and globus pallidus internus (GPi), with irregular and bursting neuronal firing patterns. Increased synchrony is found among sensorimotor networks, which may contribute to PD motor signs.”
― William J. Marks Jr., Deep Brain Stimulation Management

“The STN receives excitatory inputs from motor and premotor cortex and exerts a powerful excitatory effect on its target nuclei, GPi, globus pallidus externa (GPe), SNpr, SNpc, and the pedunculopontine nucleus (PPN).1,3–6”
― William J. Marks Jr., Deep Brain Stimulation Management

“The success of the therapy relies on three main factors: the appropriate selection of patients, the accurate placement of the DBS lead in the sensorimotor regions of the target nuclei, and optimal choice of electrical parameters for stimulation.”
― William J. Marks Jr., Deep Brain Stimulation Management