Sophia’s Reviews > Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six > Status Update

Sophia
Sophia is on page 294 of 501
Issue #342 -
Peter struggles adjusting to being only a bystander.

Not that he’s given much opportunity to sit on the side-lines when Scorpion attacks!

Of course Peter can’t take on the enhanced menace alone and calls in Black Cat (who knew Pete lost his powers).

I liked the talk the ex-couple had but this was really a fight-centred comic.

Peter gets a clue to who Turner really is.
Feb 04, 2026 07:30PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six

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Sophia’s Previous Updates

Sophia
Sophia is on page 409 of 501
Issue #347 -
Venom unfreezes Spider-Man on a deserted island.
He wants no interrupts and no heroes bailing Peter out.

Interestingly, Venom is shown to have some camouflage abilities.

Anyway, Peter realises to survive, he needs to give the madman what he wants; Spider-Man's death!

After Peter's plan works, Eddie decides to stay on the island, finally feeling free.
Mar 09, 2026 09:41PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 386 of 501
Issue #346 -
Venom is out for one thing and one thing only, the death of Spider-Man!

MJ really didn't like being shuffled off to her sisters but the way that Venom comes after Spidey, it was the only option.

Though again, we see Venom save innocents.

The issue ends with Spider-Man falling for Venom's trap!
Mar 09, 2026 09:02PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 363 of 501
Issue #345 -
Silver Sable works as the middle person between Spidey and Sapirdyne Chemicals.

Spidey agrees to get paid to do what he was gonna do anyway; search for Cardiac.

We learn why Cardiac has the powers he does and see him use them to sink an entire container ship!
(After a pointless Boomerang appearance.)

We also witness the return of Venom!

And a piece of symbiote is left with Cletus…
Mar 09, 2026 08:11PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 340 of 501
Issue #344 -
Cardiac and Spidey have a bit of a conflict when Cardiac wants to blow up chemical warehouses.

Rhino is hired to stop Cardiac but Spidey interrupts their fight.

Cardiac accomplishing his goal means another explosion in a warehouse.

The owner of Sapirdyne Chem. is informed that Spidey tried to stop the unknown hero... and wants to hire him?!

Also Eddie Brock is cellmates with... Cletus Kasidy!
Mar 09, 2026 07:26PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 317 of 501
Issue #343 -
Spider-Man and Black Cat team-up once again to crash a meeting of villains.
The mastermind is… Chameleon!

BC does quite well though, there’s too many for her to deal with alone.

Luckily, Peter regains his powers!

Of course, Chameleon gets away while his grunts are arrested.

Side effect, Felicia was partially exposed to the machine and her powers are gone (weird)!
Feb 04, 2026 08:04PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 271 of 501
Issue #341 -
Peter actually did it! He stripped himself of his powers (so much for his responsibility).

Dr Turner, who is not a kind man, contacts Tarantula to inform him of the web-slingers' new weakened status.

Lucky Spidey’s got some good friends in Flash and Felicia who help him.

Flash ends up in hospital and Felicia is suspicious of Spider-Man’s poor form.
Feb 04, 2026 07:02PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 248 of 501
Issue #340 -
Skipped pretty much all of this.

I did read the bit where Spidey trusts a random doctor to run tests on him, finds out that the machine he created weakens him and doesn't suspect this Turner guy of anything untoward?

Then after a fight, realises he doesn’t want to risk his life anymore and wants to be stripped of all his powers??
Feb 04, 2026 06:34PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 225 of 501
Issue #339 -
Caeser's plan worked. MJ met with him at the abandoned set...

Turns out though, the cop that was helping MJ is her 'biggest fan'... and is NOT a cop!

The end sees MJ saving herself and Ock finally believing Spidey when he goes for the Burundite canister instead.


Not a bad story line. I think just a little lacklustre after seeing a more dramatic Sinister Six fight on screen.
Jan 27, 2026 07:52PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 202 of 501
Issue #338 -
Peter gives his Aunt May a little bit of comfort.

Meanwhile, Jonathan Ceaser is making plans to be reunited with MJ…

Hilariously, MJ made a comment about so many costumed heroes being around.

The Sinister Six crash the rocket launch!

Sandman refuses to kill an innocent while Doc Ock kills an engineer to ensure the rocket launches with the poison.

Then... Hobgoblin poisons Spider-Man!
Jan 27, 2026 07:05PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


Sophia
Sophia is on page 178 of 501
Issue #337 -
We learn Doc Ock’s plan is… to hold the entire Earth for ransom!

He says so the Sinister Six can all rule together but of course, that’s not the truth.

Firstly, Pete and MJ walk down a street (Wolverine & Punisher cameo?) then show us what a healthy relationship looks like.

Then Flash takes on goons for Felicia.

Anyway, Spidey’s not having a good day and every villain gets away from him!
Jan 27, 2026 06:12PM
Amazing Spider-Man Epic Collection, Vol. 21: Return of the Sinister Six


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