Mark Henkel’s Reviews > Outlive: The Science & Art of Longevity > Status Update
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Mark’s Previous Updates
Mark Henkel
is on page 56 of 496
Ch.3 Complete
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
Strategy from 5 data sources:
centenarians
lifespan of "animal models"
human studies of 4 Horsemen
molecular & mechanistic studies of human & animal models (to drugs & exercise)
MR (Mendelian Randomization)
Like investment tactics for best ROI
get better than avg returns with acceptable risk,'
called ALPHA.
Achieve your own LONGEVITY ALPHA
— 12 hours, 7 min ago
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
Strategy from 5 data sources:
centenarians
lifespan of "animal models"
human studies of 4 Horsemen
molecular & mechanistic studies of human & animal models (to drugs & exercise)
MR (Mendelian Randomization)
Like investment tactics for best ROI
get better than avg returns with acceptable risk,'
called ALPHA.
Achieve your own LONGEVITY ALPHA
Mark Henkel
is on page 56 of 496
Ch.3 Complete
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
x = Lifespan
y = Healthspan
Last decade > "Marginal Decade"
"Living longer means delaying death from ALL 4 of Horsemen
(cancer, diabetes, cardiovascular disorsers, & neurodegenerative diseases"
3 vectors or deterioration:
cognitive
physical
emotional health
5 Med 3.0 tactics:
exercise
nutrition
sleep
emotional health
exogenous molecules
— 12 hours, 13 min ago
OBJECTIVE, STRATEGY, TACTICS
A Roadmap for Reading this Book
x = Lifespan
y = Healthspan
Last decade > "Marginal Decade"
"Living longer means delaying death from ALL 4 of Horsemen
(cancer, diabetes, cardiovascular disorsers, & neurodegenerative diseases"
3 vectors or deterioration:
cognitive
physical
emotional health
5 Med 3.0 tactics:
exercise
nutrition
sleep
emotional health
exogenous molecules
Mark Henkel
is on page 36 of 496
Ch.2 Complete
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
"Medicine 3.0 pays far more attn to mantaining healthspan, the quality of life"
"Longevity, itself,
and healthspan in particular,
doesn't really fit into the business model of our current healthcare system"
"money flows to treatment rather than prevention" (<--EXACTLY!)
— 12 hours, 20 min ago
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
"Medicine 3.0 pays far more attn to mantaining healthspan, the quality of life"
"Longevity, itself,
and healthspan in particular,
doesn't really fit into the business model of our current healthcare system"
"money flows to treatment rather than prevention" (<--EXACTLY!)
Mark Henkel
is on page 36 of 496
Ch.2 Complete
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
Medicine 1.0 = conclusions based on observations & guesswork
(no by more by "the gods")
2.0 = mid1800s - germ theory of disease, adding hypothesis to steps
AFTER DISEASE NOTED
100yrs less successful against longterm disease like cancer
3.0 = prevent tumors (etc) starting spreading in first place
emphasis: PREVENTION, quality of life
— 12 hours, 23 min ago
MEDICINE 3.0
Rethinking Medicine for the Age of Chronic Disease
Medicine 1.0 = conclusions based on observations & guesswork
(no by more by "the gods")
2.0 = mid1800s - germ theory of disease, adding hypothesis to steps
AFTER DISEASE NOTED
100yrs less successful against longterm disease like cancer
3.0 = prevent tumors (etc) starting spreading in first place
emphasis: PREVENTION, quality of life
Mark Henkel
is on page 20 of 496
Ch.1 Complete
THE LONG GAME
From Fast Death to Slow Death
Epitaph same as
"UPSTREAM" by D.Heath
Longevity - 2 components"
*how long you live
*how well you live
"Death rates from cancer...
hardly budged in more than 50 years...
despite 100s of Billions spent on research"
"Medicine's biggest failing...
treat conditions... AFTER (disease) is entrenched
rather than before"
Protein so important
PRACTICE of Longevity
— Feb 02, 2026 07:43PM
THE LONG GAME
From Fast Death to Slow Death
Epitaph same as
"UPSTREAM" by D.Heath
Longevity - 2 components"
*how long you live
*how well you live
"Death rates from cancer...
hardly budged in more than 50 years...
despite 100s of Billions spent on research"
"Medicine's biggest failing...
treat conditions... AFTER (disease) is entrenched
rather than before"
Protein so important
PRACTICE of Longevity
Mark Henkel
is on page 4 of 496
Introduction Complete
"Dream of the falling eggs"
— Feb 01, 2026 07:32PM
"Dream of the falling eggs"
