What's the Name of That Book??? discussion
SOLVED: Adult Fiction
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SOLVED. Entangled by Paul Jason. Mystery about evil sister with bad leg who terrorizes good sister. [s]
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Please keep in mind the bump period is 30+ days for this large group, unless you have new information which can be added any time.

I found fragment in 1982 Kirkus reviews, which might be about it:
and tracks down the shady doctor (the notorious 1950s "guinea pig surgeon") who was last seen with the corpse (?) of Diana's mutilated twin baby-sister. Meanwhile, of course, that very doctor (now an East Village veterinarian) is, together with his monster/concubine Laurie, stalking Diana. And eventually Diana will indeed wind up in the mad-doctor's chamber of horrors-praying that someone rescues her before the Doc gives Laurie the second leg she's always wanted. . . by transplanting it from Diana. Occasionally silly-gross and far from original (think of Brian da Palma's Sisters, among others), but fans of popcorn-horror will find this fast, unpretentious fun -with a few spots of surprisingly bright dialogue
SPOILER:
Bad sister kidnaps good sister but good sister is saved in the end. Came out late 70's or early 80's.