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Cracking the Aging Code
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Will science eventually conquer aging in humans?
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People's time here on earth is genetically coded. We are here to do and witness what we are here to do and witness. I met a witch once, or people swore she was a witch, in West Africa, who lived to an extraordinary age. She looked well, like a dignified and healthy 80 year old but villagers said she was close to 200 years old. She quietly confirmed this as if it was no big deal.
I'm pretty sceptical about this one:"A disturbing video shows Soviet scientists using a primitive ‘heart lung machine’ to bring a severed dog’s head back to life in 1940.
Another portion of the film, which resurfaced this week thanks to MediaDrumWorld, shows scientists fully reviving a clinically dead dog – which it’s claimed ‘lived for years’ afterwards."
https://uk.news.yahoo.com/chilling-vi...
Holy shit, mate, that's one amazing video if it's legit (looks legit to my uneducated eyes).Stuff the Yahoo News article, I'm posting the YouTube video from the Russian archives (it's one amazing video for those who have the stomach to watch it):
Russian scientists successfully reanimate dead dog's head (1940) https://www.youtube.com/watch?389=&am...
There was a patent given to a U.S. scientist in the 1970s who claimed he could transfer a do the same or something very similar with dead monkey's heads!
Harry wrote: "I'm pretty sceptical about this one:"A disturbing video shows Soviet scientists using a primitive ‘heart lung machine’ to bring a severed dog’s head back to life in 1940.
Another portion of the ..."
Do you remember the big twist in that recent Hollywood comedy-horror GET OUT?
You think that surprise blockbuster could have been leaking to us that such technologies to transfer consciousness from the elderly into youths may exist NOW?
James wrote: "Holy shit, mate, that's one amazing video if it's legit (looks legit to my uneducated eyes).Stuff the Yahoo News article, I'm posting the YouTube video from the Russian archives (it's one amazing ..."
I dunno... the camera angles are a bit iffy. The dog's head could easily be stuck through a hole and not be dismembered at all. Either the whole thing's a fake... or it's not! :)
Check out this article, Harry...it all appears to be legit as the Soviet era replicated it with multiple experiments including monkeys, I think...Sergei’s Litter https://www.damninteresting.com/serge...
"From the 1920’s through the 1950’s, a Soviet scientist by the name of Sergei S. Bryukhonenko spent countless hours slaving away in his laboratory. In his homeland, he was known as a respected researcher for his influential insights into blood transfusion. Not content with his previous achievements, Bryukhonenko wanted to push his work to the very limits of possibility. His macabre research focused on the possibility of sustaining life through artificial means. His lab was home to all manner of bizarre experiments and occurrences. His staff quickly became accustomed to the sight of disembodied heads and desiccated animal corpses. As uncomfortable and ghastly as it was, his findings would prove influential to many modern medical procedures."
https://www.damninteresting.com/serge...
p.s. Someone posted below that article:
"Can I transplant my brain into the body of a … “donor” – and thus live forever?"
And thus, we are back at square one: the ending of that movie GET OUT where it showed a mysterious elite are living forever by having their brains transferred into young people!!!!!
James wrote: "Check out this article, Harry...it all appears to be legit as the Soviet era replicated it with multiple experiments including monkeys, I think...Sergei’s Litter https://www.damninteresting.com/s..."
I'm still sitting on the fence with this one presently!
THE FIRST AMERICAN IMMORTAL— THE ALLURING PROMISE OF A FEW MORE YEARS (Includes list of Geroprotectors aka Longevity Drugs) http://renegadehealth.com/blog/2014/1...
Talk about defying age... This octogenarian lady is incredible... and only 7sec slower than Usain Bolt over 100m! https://www.facebook.com/BBCSport/vid...And this 80-year-old is only 5sec slower than Bolt!
http://www.mirror.co.uk/news/uk-news/...
Are rich people injecting "young blood" to live longer? | Like vampires! https://www.youtube.com/watch?v=8hCXY...Joe Rogan talks with Dr. Rhonda Patrick about how rich people like Billionaire PayPal founder and Trump advisor Peter Thiel are pumping themselves full of young blood to improve the aging process. Like a vampire. Do blood transfusions from that young kid down the street work?
Not if the blood has certain viruses in it. My guess is any such effect would be temporary at best. I gather some athletes use it for performance enhancement because by enriching the supply of haemoglobin or something else, they improve functionality, but that only lasts for a rather short time, so I gather.
The science surrounding Stem Cells seems to be evolving very fast now...Is this the beginning of conquering death, or slowing age/extending lives?
This podcast interview got me thinking (no idea what Mel Gibson is doing in this, but that's him even tho he hardly speaks!)...
Joe Rogan Experience #1066 - Mel Gibson & Dr. Neil Riordan https://www.youtube.com/watch?v=OtL1f...
Some books by MIT evolutionary biologist Dr. Josh Mitteldorf who researches anti-aging and even human immortality possibilities:Cracking the Aging Code: The New Science of Growing Old - And What It Means for Staying Young
Book review:
Cracking the Aging Code: The Science
Book of the Year http://roguehealthandfitness.com/age-...
What Good is Death?: Why Nature has Arranged for us to Die, and What We Can Do About It
And here are some articles he has written (with extensive scientific references):
Why Aging Isn’t Inevitable http://nautil.us/issue/36/aging/why-a...
The great variety of aging styles among plants and animals suggests it can be controlled.
"Humans age gradually, but some animals do all their aging in a rush at the end of life, while others don’t age at all, and a few can even age backward. The variety of aging patterns in nature should be a caution sign to anyone inclined to generalize—particularly the generalization that aging is inevitable."
What would it mean to live forever? https://joshmitteldorf.scienceblog.co...
Telomerase Therapies? https://joshmitteldorf.scienceblog.co...
A cure for Alzheimer’s? Yes, a cure for Alzheimer’s! https://joshmitteldorf.scienceblog.co...
Telomerase as a Fountain of Youth https://joshmitteldorf.scienceblog.co...
Can Traditional Chinese Medicine Help You Live Longer? https://joshmitteldorf.scienceblog.co...
Epigenetics and the Direction of Anti-Aging Science https://joshmitteldorf.scienceblog.co...
Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging https://www.youtube.com/watch?v=k-b7d...Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.
Even the laid back guys die, and not seriously later than the average.
For now, Ian. But I think at the very least life extension of some kind will start to become more feasible soon as tech, research, methodologies, healthcare, evolve. Unless we are encoded to die and it's bad for the human species (or any species) for individuals to live too long?
Even then tho, I think scientific research will eventually unravel what's causing aging and mysterious diseases of "old age"... Multi centurions might become a reality at some point!
But maybe don't start planning holidays for the year 2197AD just yet!!
James, the problem seems to be that aging involves a huge number of different things going wrong, or less capable, at the same time. If they do find a means of prolonging life for 300 years, say, but they don't fix the lot, you condemn them to 200 years of misery
Ian wrote: "James, the problem seems to be that aging involves a huge number of different things going wrong, or less capable, at the same time. If they do find a means of prolonging life for 300 years, say, but they don't fix the lot, you condemn them to 200 years of misery ..."But the number #1 rule of life extension is to survive, Ian :)
Therefore if you were to extend your life by 200 years, as per your example, then you'd eventually benefit from medical discoveries over those 200 years (just look back at the last 100 years). So whilst you're right that you could go thru a period of misery by surviving with a lot of pain etc, I also think it highly likely that as medicine/science evolves further those diseases could be eradicated/healed in time.
So don't cancel your holidays for the year 2197AD either!
Rahul wrote: "soul meant a differ something....."Is anyone else confused?
Lance wrote: "Rahul wrote: "soul meant a differ something....."Is anyone else confused?"
As to why, yes. As to what he is saying, there is no confusion about incomprehensibility
Rahul wrote: "do not be a misunderstand or a fool."Ah...now I get it!
Epitalon https://en.wikipedia.org/wiki/EpitalonEpitalon is a synthetic peptide, telomerase activator, and putative anti-aging drug developed by the St. Petersburg Institute of Bioregulation and Gerontology,[1][2] which was identified as the putative active component of a bovine pineal gland extract known as epithalamin.[3]
Most studies on epitalon and epithalamin have been conducted by the St. Petersburg Institute of Bioregulation and Gerontology, primarily overseen by Vladimir Khavinson, in Russia.
Chemistry
Epitalon is a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly and the molecular formula C14H22N4O9.[8]
Biological effects
Studies in vitro
Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in vitro, based on a study in human fibroblast cell cultures.[1]
Elongation of telomeres by epitalon was sufficient to surpass the Hayflick limit in a cell culture of human fetal fibroblast cells, extending their proliferative potential from termination at the 34th passage in the control cell population to beyond the 44th passage in the treated cell population, while increasing the lengths of their telomeres to levels comparable to those of cells in the original culture.[9]
Epitalon induces decondensation of heterochromatin near the centromeres in cultured lymphocytes originating from samples taken from humans of ages 76 to 80 years.[10]
Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts.[11]
Animal studies in vivo
An in vivo study in aging mice found that epitalon treatment significantly reduced the incidence of chromosomal aberrations, both for wild-type mice and for mice characterized by an accelerated aging phenotype, which is consistent with increases in telomere length.[12]
Another study in aging rats found that epitalon increased the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase.[3]
Epitalon reduced the number of spontaneous tumors and the number of metastases in mice that did develop spontaneous tumors in an experiment on one-year-old female C3H/He mice, and is speculated to have oncostatic and anti-metastatic properties.[13]
In a study of chickens subjected to neonatal hypophysectomy and subsequent maturation, epitalon promoted the recovery of the morphological structures of the thymus,[14] as well as the structure and function of the thyroid gland.[15]
Epitalon appears to increase the proliferation of lymphocytes in the thymus, putatively increasing production of interferon gamma by T-cells.[16]
Another study in aging rats demonstrated extension of life span for rats subjected to constant illumination or to a natural light regimen typical of northern regions.[8]
Human clinical studies
In human clinical studies, epitalon and epithalamin both significantly increased telomere lengths in the blood cells of patients of ages 60-65 and 75-80, and their efficacy was comparable to one another.[17][18]
Epitalon and epithalamin appear to restore melatonin secretion by the pineal gland[3] in both aged monkeys and humans.[19]
A human clinical trial conducted on a sample of retinitis pigmentosa patients found that epitalon produced a positive clinical effect in 90% of cases in the treated group.[20]
In another human clinical trial conducted on a sample of pulmonary tuberculosis patients, epitalon did not appear to correct pre-existing structural aberrations of chromosomes associated with telomere degradation, but did appear to exert a protective effect against the future development of additional chromosomal aberrations.[21]
A human prospective cohort study conducted on a sample of 266 people over age 60 demonstrated that treatment with epithalamin, the pineal gland extract upon which epitalon is based, produced a 1.6–1.8-fold reduction in mortality during the following 6 years, a 2.5-fold reduction in mortality when combined with thymulin, and a 4.1-fold reduction in mortality when combined with thymulin and administered annually instead of only once at study onset.[22][23]
Another prospective cohort study on a sample of 79 coronary patients spanning in excess of 12 years found improved metrics of physical endurance, circadian rhythm, and carbohydrate and lipid metabolism in the treated group relative to the control group following 3 years of biannual epithalamin treatments, as well as a 50% lower rate of cardiovascular mortality, a 50% lower rate of cardiovascular failure and serious respiratory disease, and a 28% lower rate of overall mortality.[24][25]
Biologists identify pathways that extend lifespan by 500% https://m.phys.org/news/2020-01-biolo...Jarod A. Rollins of the MDI Biological Laboratory in Bar Harbor, Maine, is a lead author of a recent scientific paper that identifies synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. The increase in lifespan would be the equivalent of a human living for 400 or 500 years. The discovery of the synergistic effect opens the door to new, more effective anti-aging therapies. Credit: MDI Biological Laboratory
In my case, I doubt they will be fast enough :-(
Ian wrote: "In my case, I doubt they will be fast enough :-("Don't short-change yourself Ian. You're a spring chicken and we'll likely have to put up with you for decades yet!
"Put up with me"??? Hmm - made my day :-)
I meant that in the kindest possible way.
Lance wrote: "I meant that in the kindest possible way."I know. So did I :-)
Underground Knowledge — A discussion group
Books mentioned in this topic
Cracking the Aging Code: The New Science of Growing Old - And What It Means for Staying Young (other topics)What Good is Death?: Why Nature has Arranged for us to Die, and What We Can Do About It (other topics)
The Quest for Immortality: Science at the Frontiers of Aging (other topics)
The Book of Immortality: The Science, Belief, and Magic Behind Living Forever (other topics)
Long for This World: The Strange Science of Immortality (other topics)
More...
Authors mentioned in this topic
Josh Mitteldorf (other topics)Mel Gibson (other topics)
Peter Thiel (other topics)
Joseph P. Farrell (other topics)
Ben Bova (other topics)
Yes I recall blood doping in sports (especially cycling) was big a few years back... or a big concern at least. My impression was it did only provide a temporary boost.