“The brain likes to know the pattern occurring moment to moment; it craves certainty, so that prediction is possible. Without prediction, the brain must use dramatically more resources, involving the more energy-intensive prefrontal cortex, to process moment-to-moment experience. Even a small amount of uncertainty generates an “error” response in the orbital frontal cortex. This takes attention away from one’s goals, forcing attention to the error. . . . Larger uncertainties, like not knowing your boss’s expectations or if your job is secure, can be highly debilitating.”