“Endocannabinoids appear to be profoundly connected with the concept of homeostasis (maintaining physiological stability), helping redress specific imbalances presented by disease or by injury. Endocannabinoids’ role in pain signaling has led to the hypothesis that endocannabinoid levels may be responsible for the baseline of pain throughout the body, which is why cannabinoid-based medicines may be useful in treating conditions such as fibromyalgia (a condition marked by muscular pain and stiffness). This could also mean that the constant release of the body’s own endocannabinoids could have a “tonic” effect on muscle tightness (spasticity) in multiple sclerosis, neuropathic pain, inflammation, and even baseline appetite. The value of proper “endocannabinoid tone” throughout the body could be very significant to general well-being.”