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“I suspect that the real reason that we are not more bothered by this argument is that nobody—nobody—really takes its conclusion seriously. If you did seriously consider that we can make no reasonable predictions about the future, and so we can make no rational decision about any action, you would soon be insane and probably would be involuntarily frozen into total catatonic immobility. As for Popper's recommendations, then, I think we have to say that if this be methodology, there is madness in it.”

Howard Margolis, It Started With Copernicus: How Turning the World Inside Out Led to the Scientific Revolution
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