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This answer contains spoilers… (view spoiler)[well, natural selection, in terms of intelligence, strength, power and authority. it applies to both people and animals (dog that gets killed because it is old and stinky). crooks and racism, lennie who is big and dumb (george shoots him because he is unfit to survive), curly (small man syndrome) who is competitive, aggressive towards lennie and other big fellows, the boss has the authority because he owns the farm and has financial strength, slim keeps the biggest dog because it is most likely to survive...etc. it is the main theme of this book. (hide spoiler)]
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