Why Zebras Don't Get Ulcers: The Acclaimed Guide to Stress, Stress-Related Diseases, and Coping
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A stressor is anything in the outside world that knocks you out of homeostatic balance, and the stress-response is what your body does to reestablish homeostasis.
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One of the hallmarks of the stress-response is the rapid mobilization of energy from storage sites and the inhibition of further storage.
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It is not so much that the stress-response runs out, but rather, with sufficient activation, that the stress-response can become more damaging than the stressor itself, especially when the stress is purely psychological.
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Thus, the autonomic system works in opposition: sympathetic and parasympathetic projections from the brain course their way out to a particular organ where, when activated, they bring about opposite results.
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Whenever you inhale, you turn on the sympathetic nervous system slightly, minutely speeding up your heart. And when you exhale, the parasympathetic half turns on, activating your vagus nerve in order to slow things down (this is why many forms of meditation are built around extended exhalations).