Physical Consequences In our evolutionary past, when most people died by forty or so, the short-term benefits of SNS/HPAA activation outweighed its long-term costs. But for people today who are interested in living well during their forties and beyond, the accumulating damage of an overheated life is a real concern. For example, chronic SNS/HPAA stimulation disturbs these systems and increases risks for the health problems listed (Licinio, Gold, and Wong 1995; Sapolsky 1998; Wolf 1995): Gastrointestinal—ulcers, colitis, irritable bowel syndrome, diarrhea, and constipation Immune—more frequent
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