decreases the activity of cyclic AMP and protein kinase A. This finding suggested to him that the peptide may compromise the cyclic AMP-protein kinase A system. Indeed, he found that increasing cyclic AMP via Rolipram prevents Aβ toxicity in mouse neurons. The same drugs that prevent age-related memory loss in mice also prevent memory deficits in mice in the early stages of Alzheimer’s disease. Ottavio Arancio from Columbia University went on to show that Rolipram protects against some of the damage to neurons sustained in Alzheimer’s, thereby suggesting that cyclic AMP not only strengthens
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