In their wandering passage through the Caribbean, the ships with their sick crews unknowingly spread epidemics of illness at many of the ports they visited. By 1494, these epidemics merged into a plague raging across Hispaniola and the rest of the Caribbean. “There came among [the Indians] such illness, death and misery,” Bartolomé de las Casas wrote, “that of fathers, mothers and children, an infinite number sadly died.” He estimated that a third of the population died in the two years from 1494 to 1496.
