A symbiotic combination of prebiotics and spermidine-producing Bifidobacteria was able to increase spermidine levels in people’s blood. This then translated in a randomized, double-blind, placebo-controlled trial to improve endothelial function,463 thought due to a boost of autophagy.464 Spermidine-producing bacteria are fiber-feeding,465 so prebiotics alone would likely foster the growth of more spermidine producers. Then, even if you miss a day, your colonic colleagues can pick up the slack. Since beans and whole grains are leading sources of spermidine and also the fiber and resistant
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