It makes sense that protein intake can drive mTOR activation. It’s not enough to have energy (calories); construction crews need building materials. Yes, insufficient calories can shut down mTOR by cranking up AMPK, but calories aren’t the primary inducer of mTOR activity—amino acids are, the building blocks of proteins.1376 That’s good news. Protein restriction is much easier and safer to maintain than dietary restriction, and it may be even more powerful

