For example, the Nrf2 gene is overexpressed sixfold in long-lived naked mole rats compared to mice,1660 combined with lower suppressor protein expression.1661 That may not only help explain why they live eight times longer1662 but also why it takes up to a hundred times the concentration of toxins like heavy metals and chemotherapy drugs to kill the same percentage of skin cells taken from naked mole rats compared to mice.1663 They are little nude detoxification machines. Unfortunately, Nrf2 levels1664 and signaling tend to decrease with age.
