Sirtuins are a class of protein regulators that appear to play a key role in protecting us against a variety of age-related diseases, though their role in longevity is questionable.1920 Dependent on a molecule called NAD+, sirtuins can be upregulated by anything that increases NAD+ levels, including AMPK activation. Certain foods and supplements may also be able to activate sirtuins in other ways, but research on resveratrol has been largely disappointing and raised certain safety concerns.
