The way AMPK enhances sirtuin activity is by increasing levels of cellular nicotinamide adenine dinucleotide (NAD+).1828 NAD+ is a critical cofactor necessary for sirtuin activity. Alternate means of boosting NAD+ levels include taking a variety of NAD+ precursors,1829 as I’ll discuss in the Anti-Aging Eight section. Raising NAD+ levels is one of two basic approaches to sirtuin stimulation.1830 The other is via STACs, sirtuin-activating compounds, the most widely known of which is resveratrol,1831 a natural compound concentrated in the skin of grapes.
