Another strike against mescaline is that a dose requires up to half a gram of the chemical; compare that to LSD, doses of which are measured in micrograms—millionths of a gram. In the illicit drug trade, more material means more risk. Which probably explains why LSD, virtually weightless and easy to hide, came to eclipse mescaline, rendering it, by the mid-1960s, an orphan psychedelic.
