Something can be considered a cancer when it: Grows—it sustains proliferative signaling (hallmark 1), evades growth suppressors (2), resists cell death (3), and induces angiogenesis (5); Is immortal—it enables replicative immortality (4); Moves around—it activates invasion and metastasis (6) and evades immune destruction (8); and Uses the Warburg effect—it deregulates cellular energetics (7).
