First, we all respond to carbohydrates differently. Enormous variation exists from person to person. That’s one very good reason why, given the same foods to eat, some of us will grow up to be built like fashion models and some of us will be extremely obese. Moreover, different cells and tissues even in the same individual respond differently to insulin. Here, too, there’s enormous variation. When tissues and cells become resistant to insulin, they do so at different rates and different levels of insulin in the circulation.