It wasn’t long before researchers discovered that the compound was an effective suppressor of the immune system. That would end its potential as an antifungal—there are plenty of remedies for athlete’s foot that don’t come at the cost of lowered immunity—but it gave scientists a new attribute to study. Even in the 1960s, researchers knew that one of the most common reasons for an organ transplant to fail is that the recipient patient’s body rejects it. Could rapamycin lower the immune response enough to ensure the organ would be accepted? Indeed it could.
Check rapamycin's relationship as an anti inflamamatant (possibly) cellular autophagy and mTOR relationship.