Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine’s 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer.
For decades, the medical community has looked to a...more
So then what is taking up the bulk of these 400+ pages?
Anecdotes, personal backgro ...more
Sinclair, a professor of genetics and expert in the field of the science of aging from the Harvard medical school, summarizes the status quo of how to stay young and healthy as long as possible.
At the moment, the way to a longer life is a pretty hard one, focussing on some elemental and prooven elements:
Workout for both strength and ...more
Many of Dr. Sinclair's recommendations such as calorie restriction (CR), exercise, sleep and moderate to low protein intake are well vetted.
Other suggestions including the intake of NAD, Metformin, and Rapamycin MAY have anti-aging effects but are less well known and have potential downsides.
Since living long sound ...more
Solving aging is one of the final frontiers for humankind, and the information David has provided here is a big step in the right direction. It has the power to bring more awareness to solving aging as well as shift strong limiting beliefs that have been deeply rooted in public as well as the scientific community.
We've come very far in ...more
It's well-written and I enjoyed Prof. Sinclair's distinctive writing style and purview. I learned a bit on what papers and authors I should read more deeply for Parts (1) and (2) ...more
Sinclair believes that our attitudes about the inevitability of aging may be somewhat flawed. In fact, based on his research, he believes that not only will we be able to slow aging down, we may someday be able to reverse it.
He discusses the shortcomings of aging research that is partly a function of the fact that we don't currently classify aging as a chronic disease, thereby making its research ineligible fo ...more
Now for the long version...
My previous knowledge of David Sinclair was from his visits to JRE podcast, where I found ...more
Gene therapies that can reverse organ damage, like macular degeneration, and get rid of senescent cells, which increase with age and cause the various illnesses of old age, are already proving to be successful in the lab.
We will be able to program genes in a way that makes humans immune to most fatal diseases. A Chinese doctor has already gene edited a girl who is immu ...more
And 1% on how you should exclude animal proteins, sugar, dairy, and eat a lot less of everything else (calorie restriction).
Understandable and well-communicated science underpinning human longevity. David wrote it in a way a layman like myself could easily understand. The book lays down the existing science. Past (what we know) and moves to where we are now. Present. (what we are learning). Then moves through to where we are going (future - breakthrough science) and this is where it starts to get really existing.
The fu ...more
How would you feel about living an extra thirty years? And how about if those years were relatively disease-free and healthy ones? If everybody lived that extra thirty or more years, would that necessarily be a good thing? What would happen to families, work, and society with double the elderly population as today?
These questions and more are examined in this fascinating book by Dr. David Sinclair, one of the leading experts on aging and founder of a prestigious laboratory at Harvard Universi ...more
At first glance one would look at the book cover and say it is a tall order. Not knowing who is David Sinclair, one would assume that this best selling book is another hocus self-help or motivational book. But once you start reading, you'd get to realize that this is the real thing. David has a Ph.D. in Molecular Genetics and is a researcher at Harv ...more
In the third part, I did not expect to discuss the possible effects of a healthy ageing population with longer lifespan. Some questions are highlighted like : Do saving more life leads to overpopulation? And What wil ...more
For me, there 3 main 3 thesis:
1. Agin ...more
Most people associated it with their eating habits - this book attributes the lifespan (and healthspan) to what (and when) they're *NOT* eating (via negativa).
This is a prime example for all the confusion we're bombarded about nutrition: every "study" has an equal, opposite "study" (mostly observational ones, obviously), and we didn't even care to look for what's missing (since it's always easier to just c ...more
There are no "how to" steps in the book othe ...more
There is no magical bill for longevity and vitality, but Dr. Sinclair claims that the use of NMN, resveratrol and metformin can be beneficial at the DNA level. In addition, following a healthy lifestyle is a key Ingredient to stay younger and healthier ...more
I really appreciate the advanced copy for review!! ...more
The author basically claims that in the last 20 years or so scientist have pretty much figured out how aging works, and they also have some good idea how to slow that down and even reverse it. He goes into a lot of scientific and experimental details, that some might find boring and too much, but I really enjoye ...more