Yamanaka factors from birth; these can be turned on by injecting the mice with doxycycline. In a now-famous study from 2016, when Belmonte triggered the Yamanaka factors for just two days a week throughout the lifespan of a prematurely aging mouse breed called LMNA, the mice remained young compared to their untreated siblings and lived 40 percent longer.11 He’s shown that the skin and kidneys of regular old mice heal more quickly, too. The Yamanaka treatment, however, was highly toxic.
Yamanaka treatments and their risky toxicity, you must stay on the edge of life to prevent senescence.
