Lifespan: The Revolutionary Science of Why We Age—and Why We Don't Have To

by David A. Sinclair

Type 1 diabetes, which occurs when the pancreas doesn’t produce enough of the hormones needed to alert the body to sugar, is now widely treated by supplemental insulin. But the fight was not over. The type 2 version of the disease, so-called age-associated diabetes, occurs when the pancreas is able to make enough insulin but the body is deaf to it. The 9 percent of all adults globally with this disease need a drug that restores their body’s sensitivity to insulin so cells take up and use the sugar that’s coursing through their bloodstreams. That’s important for at least two reasons: it gives the overworked pancreas a rest, and it prevents spikes of freely floating sugar from essentially caramelizing proteins in the body. Recent results indicate high blood sugar can also speed up the epigenetic clock.

I'll Weed off the keto cycle soon: with a reduction of insulin sensitivity I'll switch to plant proteins to reintroduce carbs (50-75g) into my diet. Too much animal amino acids.