In 1957, Sterne published a paper demonstrating the effectiveness of oral dimethyl biguanide to treat type 2 diabetes. The drug, now most commonly called metformin, has since become one of the most widely taken and effective medicines on the globe. It’s among the medications on the World Health Organization’s Model List of Essential Medicines, a catalog of the most effective, safe, and cost-effective therapies for the world’s most prevalent medical conditions.
I believe metformin also doesn't significantly raise insulin levels
