Precise vibrating sockets on SIRT1 simultaneously clasp onto an NAD molecule and the protein it wants to strip the acetyls from, such as a histone or FOXO3. The two captured molecules immediately lock together, just before SIRT1 rips them apart in a different way, producing vitamin B3 and acetylated adenine ribose as waste products that are recycled back to NAD.
Differential between Niacin and Niacotinamide
