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These cases could, perhaps, be the result of a placebo effect. But a trial in 2018 to test whether an NAD booster could restore the fertility of old horses was successful, surprising the skeptical supervising veterinarian. As far as I know, horses don’t experience the placebo effect.
Stone
Even menopause. horse without placebo effect
Lifespan: The Revolutionary Science of Why We Age—and Why We Don't Have To
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