One study of genetically engineered Ames dwarf mice, for instance, demonstrated that the function of brown fat is enhanced in these remarkably long-lived animals.43 Other studies have shown that animals with abundant brown fat or subjected to shivering cold for three hours a day have much more of the mitochondrial, UCP-boosting sirtuin, SIRT3, and experience significantly reduced rates of diabetes, obesity, and Alzheimer’s disease.44