The Botany of Desire: A Plant's-Eye View of the World

by Michael Pollan

On the assumption that the human brain would not have evolved a special structure for the express purpose of getting itself high on marijuana, researchers hypothesized that the brain must manufacture its own THC-like chemical for some as-yet-unknown purpose. (The scientific paradigm at work here was the endorphin system, which is tripped by opiates from plants as well as endorphins produced in the brain.) In 1992, some thirty years after his discovery of THC, Raphael Mechoulam (working with a collaborator, William Devane) found it: the brain’s own endogenous cannabinoid. He named it “anandamide,” from the Sanskrit word for “inner bliss.”