the chemical compound responsible for the psychoactive effects of marijuana: delta-9-tetrahydrocannabinol, or THC, a molecule with a structure unlike any found in nature before or since. For years Mechoulam had been intrigued by the ancient history of cannabis as a medicine (a panacea in many cultures until its prohibition in the 1930s, it has been used to treat pain, convulsions, nausea, glaucoma, neuralgia, asthma, cramps, migraine, insomnia, and depression)