More on this book
Community
Kindle Notes & Highlights
by
Jason Fung
Read between
April 28 - April 29, 2019
accumul...
This highlight has been truncated due to consecutive passage length restrictions.
Too much insulin signals the liver to keep admitting glucose, resulting in more production of new fat via DNL. Normally, if periods of high insulin (feeding) alternate with periods of low insulin (fasting), weight remains stable. If high insulin persists...
This highlight has been truncated due to consecutive passage length restrictions.
fat.
This highlight has been truncated due to consecutive passage length restrictions.
hyperinsulinemia, high levels of insulin in the blood, directly causes
weight gain.
Where excessively high insulin levels lead to weight gain, excessively
low insulin levels lead to weight loss.
Increasing insulin causes weight
gain. Decreasing insulin causes weight loss. These are not merely correlations
but direct causal factors. Our hormones, mostly insulin, ultimately set our body weight and level of body fat....
This highlight has been truncated due to consecutive passage length restrictions.
imbalance, not a cal...
This highlight has been truncated due to consecutive passage length restrictions.
HYPERINSULINEMIA CAUSES OBESITY.
After all, if obesity causes insulin resistance, how could type 2 diabetes develop in normal-weight patients? And why do so many
obese people not develop type 2 diabetes?
The converse, the idea that insulin resistance causes obesity, is implausible since obesity typically predates insulin resistance. The only
remaining possibility is that some X factor is the underlying cause of both obesity and insulin resistance. The connection, as we shall see, is too much insulin. The X factor is hyperinsulinemia.
Exposure creates resistance. Excessively high and prolonged levels of anything provoke resistance by the body. This is a normal phenomenon. Consider the
following.
Since the body doesn’t want to die (and neither do we), it protects itself by developing insulin resistance,
demonstrating homeostasis.
The resistance develops naturally to shield against the unusually high insulin level...
This highlight has been truncated due to consecutive passage length restrictions.
resis...
This highlight has been truncated due to consecutive passage length restrictions.
Exposure creates resistance. Removing the stimulus also removes
the resistance.
predicted the emergence of resistance two years before
Removing the stimulus removes the resistance. Unfortunately, the knee-jerk reaction of many doctors is just the opposite: to prescribe more antibiotics to overcome the resistance, which backfires and creates even more resistance.
Exposure creates resistance. And what does this tell us about insulin resistance? Insulin causes insulin resistance.
HORMONES, SUCH AS insulin, act much like drugs when it comes to resistance. Both act upon cell surface receptors, and they show the same phenomenon of resistance. In the case of insulin, prolonged and excessive exposure to this hormone—hyperinsulinemia—causes
insulin
resis...
This highlight has been truncated due to consecutive passage length restrictions.
For resistance to develop, two essential factors are required: high hormonal levels and constant stimulus. Normally, insulin is released in
bursts, preventing insulin resistance from developing. But when the body is constantly bombarded with insulin, resistance develops.
with insulin, resistance...
This highlight has been truncated due to consecutive passage length restrictions.
It’s a vicious, self-reinforcing cycle: exposure creates resistance. Resistance leads to higher
exposure.
Higher exposure i...
This highlight has been truncated due to consecutive passage length restrictions.
resis...
This highlight has been truncated due to consecutive passage length restrictions.
When constant high levels of insulin “yell” for glucose to enter the cell, it has ...
This highlight has been truncated due to consecutive passage length restrictions.
(insulin resistance). The body’s knee-jerk reaction is to...
This highlight has been truncated due to consecutive passage length restrictions.
insulin—to yell even l...
This highlight has been truncated due to consecutive passage length restrictions.
l...
This highlight has been truncated due to consecutive passage length restrictions.
it yells, the less effe...
This highlight has been truncated due to consecutive passage length restrictions.
Hyperinsulinemia drives the vicious cycle. Hyperinsulinemia leads to insulin resistance, which leads ...
This highlight has been truncated due to consecutive passage length restrictions.
The cycle keeps going around and
around, until the insulin levels in the body are extremely high, which drives
weight gain and ...
This highlight has been truncated due to consecutive passage length restrictions.
The longer the cycle continues, the worse it becomes, which...
This highlight has been truncated due to consecutive passage length restrictions.
insulin resistance ar...
This highlight has been truncated due to consecutive passage length restrictions.
depen...
This highlight has been truncated due to consecutive passage length restrictions.
People can be stuck in this vicious cycle for decades, developing significant insulin resistan...
This highlight has been truncated due to consecutive passage length restrictions.